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Alterations of MEN1 and E-cadherin/β-catenin complex in sporadic pulmonary carcinoids

  • Authors:
    • Serena Veschi
    • Rossano Lattanzio
    • Gitana Maria Aceto
    • Maria Cristina Curia
    • Salvatore Magnasco
    • Domenico Angelucci
    • Alessandro Cama
    • Mauro Piantelli
    • Pasquale Battista
  • View Affiliations / Copyright

    Affiliations: Department of Experimental and Clinical Sciences, University ‘G. d'Annunzio’-Chieti-Pescara, I-66013 Chieti, Italy, Department of Medical, Oral and Biotechnological Sciences, University ‘G. d'Annunzio’-Chieti-Pescara, I-66013 Chieti, Italy, Division of Pathology, ‘SS. Annunziata’ Hospital, I-66013 Chieti, Italy, Department of Drug Sciences, University ‘G. d'Annunzio’-Chieti-Pescara, I-66013 Chieti, Italy
    Copyright: © Veschi et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 1221-1228
    |
    Published online on: July 20, 2012
       https://doi.org/10.3892/ijo.2012.1563
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Abstract

Pulmonary carcinoids, distinct in typical and atypical, represent 2-5% of all primary lung tumors. The aim of this study was to investigate the molecular alterations correlated with the development of this form of neoplasms. A collection of 38 paraffin-embedded apparently sporadic carcinoids was investigated, through a combined study, for protein expression/localization of menin, p53, β-catenin and E-cadherin and for mutational analysis of the MEN1, TP53 and CTNNB1 genes. Menin was expressed in 71% of cases, with a prevalent cytoplasmic (c) localization, β-catenin was expressed in 68.4% of cases, of which 36.8% with a membranous (m) and 31.6% with a cytoplasmic localization. Membranous E-cadherin immunoreactivity was detected in 84.2% cases, nuclear p53 expression in 5.3% of cases. Positive correlation was found between c-menin and c-β-catenin expression (rho=0.439, P=0.008). In addition, m-β-catenin showed a positive correlation with both c-β-catenin and E-cadherin expression (rho=0.380, P=0.022 and rho=0.360, P=0.040, respectively). With regard to the E-cadherin/β-catenin complex, we found also a significant positive correlation between c-menin and ‘disarrayed’ β-catenin expression (rho=0.481, P=0.007). MEN1 gene variants were characterized in 34% of cases. c-menin was more highly expressed in tumors with MEN1 variants, compared to tumors without MEN1 variants (P=0.023). Three nucleotide variants of TP53 were also detected. This study confirms the involvement of the MEN1 gene in the development of sporadic pulmonary carcinoids, demonstrates the accumulation of menin in the cytoplasm, and indicates that the disarrayed pattern of the complex significantly correlates with c-menin accumulation.
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Copy and paste a formatted citation
Spandidos Publications style
Veschi S, Lattanzio R, Aceto GM, Curia MC, Magnasco S, Angelucci D, Cama A, Piantelli M and Battista P: Alterations of MEN1 and E-cadherin/β-catenin complex in sporadic pulmonary carcinoids. Int J Oncol 41: 1221-1228, 2012.
APA
Veschi, S., Lattanzio, R., Aceto, G.M., Curia, M.C., Magnasco, S., Angelucci, D. ... Battista, P. (2012). Alterations of MEN1 and E-cadherin/β-catenin complex in sporadic pulmonary carcinoids. International Journal of Oncology, 41, 1221-1228. https://doi.org/10.3892/ijo.2012.1563
MLA
Veschi, S., Lattanzio, R., Aceto, G. M., Curia, M. C., Magnasco, S., Angelucci, D., Cama, A., Piantelli, M., Battista, P."Alterations of MEN1 and E-cadherin/β-catenin complex in sporadic pulmonary carcinoids". International Journal of Oncology 41.4 (2012): 1221-1228.
Chicago
Veschi, S., Lattanzio, R., Aceto, G. M., Curia, M. C., Magnasco, S., Angelucci, D., Cama, A., Piantelli, M., Battista, P."Alterations of MEN1 and E-cadherin/β-catenin complex in sporadic pulmonary carcinoids". International Journal of Oncology 41, no. 4 (2012): 1221-1228. https://doi.org/10.3892/ijo.2012.1563
Copy and paste a formatted citation
x
Spandidos Publications style
Veschi S, Lattanzio R, Aceto GM, Curia MC, Magnasco S, Angelucci D, Cama A, Piantelli M and Battista P: Alterations of MEN1 and E-cadherin/β-catenin complex in sporadic pulmonary carcinoids. Int J Oncol 41: 1221-1228, 2012.
APA
Veschi, S., Lattanzio, R., Aceto, G.M., Curia, M.C., Magnasco, S., Angelucci, D. ... Battista, P. (2012). Alterations of MEN1 and E-cadherin/β-catenin complex in sporadic pulmonary carcinoids. International Journal of Oncology, 41, 1221-1228. https://doi.org/10.3892/ijo.2012.1563
MLA
Veschi, S., Lattanzio, R., Aceto, G. M., Curia, M. C., Magnasco, S., Angelucci, D., Cama, A., Piantelli, M., Battista, P."Alterations of MEN1 and E-cadherin/β-catenin complex in sporadic pulmonary carcinoids". International Journal of Oncology 41.4 (2012): 1221-1228.
Chicago
Veschi, S., Lattanzio, R., Aceto, G. M., Curia, M. C., Magnasco, S., Angelucci, D., Cama, A., Piantelli, M., Battista, P."Alterations of MEN1 and E-cadherin/β-catenin complex in sporadic pulmonary carcinoids". International Journal of Oncology 41, no. 4 (2012): 1221-1228. https://doi.org/10.3892/ijo.2012.1563
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