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Article Open Access

First human study in treatment of unresectable liver metastases from colorectal cancer with irinotecan-loaded beads (DEBIRI)

  • Authors:
    • K. Eichler
    • S. Zangos
    • M. G. Mack
    • R. Hammerstingl
    • T. Gruber-Rouh
    • C. Gallus
    • T. J. Vogl
  • View Affiliations / Copyright

    Affiliations: Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Johann Wolfgang Goethe-University, D-60590 Frankfurt, Germany
    Copyright: © Eichler et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 1213-1220
    |
    Published online on: July 25, 2012
       https://doi.org/10.3892/ijo.2012.1572
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Abstract

The objective of this pilot clinical study was to assess the safety, technical feasibility, pharmacokinetic (PK) profile and tumour response of DC Bead™ with irinotecan (DEBIRI™) delivered by intra-arterial embolisation for the treatment of metastatic colorectal cancer. Eleven patients with unresectable liver metastases from CRC, tumour burden <30% of liver volume, adequate haematological, liver and renal function, performance status of <2 were included in this study. Patients received up to 4 sessions of TACE with DEBIRI at 3-week intervals. Feasibility of the procedure, safety and tumour response were assessed after each cycle. PK was measured after the first cycle. Patients were followed up to 24 weeks. Only mild to moderate adverse events were observed. DEBIRI is a technically feasibile procedure; no technical complications were observed. Average Cmax for irinotecan and SN-38 was 194 ng/ml and 16.7 ng/ml, respectively, with average t½ of 4.6 h and 12.4 h following administration of DEBIRI. Best overall response during the study showed disease control in 9 patients (2 patients with partial response and 7 with stable disease, overall response rate of 18%). Our study shows that transarterial chemoembolisation with irinotecan-loaded DC beads (DEBIRI) is safe, technically feasible and effective with a good PK profile.
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1 

Fiorentini G AC, Montagnani F, Tilli M, Mambrini A and Benea G: Trans-arterial chemoembolisation of metastatic colorectal carcinoma (mCRC) to the liver adopting polyvinylalcohol microspheres loaded with irinotecan (DEBIRI) compared to FOLFIRI (CT): evaluation at two years of a phase III clinical trial. Ann Oncol. 21:2010.

2 

Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 127:2893–2917. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Pazdur R, Coia L, Hoskins WJ and Wagman LD: Cancer management: a multidisciplinary approach. Medical, Surgical and Radiation Oncology. 7th edition. CMP Healthcare Media; New York, NY: 2004

4 

Fong Y, Cohen AM, Fortner JG, et al: Liver resection for colorectal metastases. J Clin Oncol. 15:938–946. 1997.PubMed/NCBI

5 

Adam R: Chemotherapy and surgery: new perspectives on the treatment of unresectable liver metastases. Ann Oncol. 14(Suppl 2): ii13–ii16. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Adam R, Delvart V, Pascal G, et al: Rescue surgery for unresectable colorectal liver metastases downstaged by chemotherapy: a model to predict long-term survival. Ann Surg. 240:644–658. 2004.PubMed/NCBI

7 

Stangl R, Altendorf-Hofmann A, Charnley RM and Scheele J: Factors influencing the natural history of colorectal liver metastases. Lancet. 343:1405–1410. 1994. View Article : Google Scholar : PubMed/NCBI

8 

Scheele J, Stang R, Altendorf-Hofmann A and Paul M: Resection of colorectal liver metastases. World J Surg. 19:59–71. 1995. View Article : Google Scholar : PubMed/NCBI

9 

Fong Y: Hepatic colorectal metastasis: current surgical therapy, selection criteria for hepatectomy, and role for adjuvant therapy. Adv Surg. 34:351–381. 2000.PubMed/NCBI

10 

Fong Y and Blumgart LH: Hepatic colorectal metastasis: current status of surgical therapy. Oncology (Williston Park). 12:1489–1503. 1998.PubMed/NCBI

11 

Meyerhardt JA and Mayer RJ: Systemic therapy for colorectal cancer. N Engl J Med. 352:476–487. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Kennedy A, Nag S, Salem R, et al: Recommendations for radioembolization of hepatic malignancies using yttrium-90 microsphere brachytherapy: a consensus panel report from the radioembolization brachytherapy oncology consortium. Int J Radiat Oncol Biol Phys. 68:13–23. 2007. View Article : Google Scholar

13 

Germer CT, Buhr HJ and Isbert C: Nonoperative ablation for liver metastases. Possibilities and limitations as a curative treatment. Chirurg. 76:552–563. 2005.(In German).

14 

Brown DB, Geschwind JF, Soulen MC, Millward SF and Sacks D: Society of Interventional Radiology position statement on chemoembolization of hepatic malignancies. J Vasc Interv Radiol. 17:217–223. 2006. View Article : Google Scholar

15 

Bavisotto LM, Patel NH, Althaus SJ, et al: Hepatic transcatheter arterial chemoembolization alternating with systemic protracted continuous infusion 5-fluorouracil for gastrointestinal malignancies metastatic to liver: a phase II trial of the Puget Sound Oncology Consortium (PSOC 1104). Clin Cancer Res. 5:95–109. 1999.

16 

Vogl TJ, Straub R, Eichler K, Sollner O and Mack MG: Colorectal carcinoma metastases in liver: laser-induced interstitial thermotherapy - local tumor control rate and survival data. Radiology. 230:450–458. 2004. View Article : Google Scholar

17 

Fiorentini G, Aliberti C, Turrisi G, et al: Intraarterial hepatic chemoembolization of liver metastases from colorectal cancer adopting irinotecan-eluting beads: results of a phase II clinical study. In Vivo. 21:1085–1091. 2007.

18 

Aliberti C, Tilli M, Benea G and Fiorentini G: Trans-arterial chemoembolization (TACE) of liver metastases from colorectal cancer using irinotecan-eluting beads: preliminary results. Anticancer Res. 26:3793–3795. 2006.

19 

Rofe APS: A preclinical study to evaluate the plasma levels of irinotecan after hepatic embolisation using drug loaded in a porcine model. Institute of Medical and Veterinary Science; Adelaide: 2006

20 

Therasse P, Arbuck SG, Eisenhauer EA, et al: New guidelines to evaluate the response to treatment in solid tumors European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst. 92:205–216. 2000. View Article : Google Scholar

21 

Locker GY, Hamilton S, Harris J, et al: ASCO 2006 update of recommendations for the use of tumor markers in gastrointestinal cancer. J Clin Oncol. 24:5313–5327. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Chong G and Cunningham D: Improving long-term outcomes for patients with liver metastases from colorectal cancer. J Clin Oncol. 23:9063–9066. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Cohen AD and Kemeny NE: An update on hepatic arterial infusion chemotherapy for colorectal cancer. Oncologist. 8:553–566. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Saltz LB, Cox JV, Blanke C, et al: Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group N Engl J Med. 343:905–914. 2000. View Article : Google Scholar : PubMed/NCBI

25 

Leonard GD, Brenner B and Kemeny NE: Neoadjuvant chemotherapy before liver resection for patients with unresectable liver metastases from colorectal carcinoma. J Clin Oncol. 23:2038–2048. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Llovet JM and Beaugrand M: Hepatocellular carcinoma: present status and future prospects. J Hepatol. 38(Suppl 1): S136–S149. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Lo CM, Ngan H, Tso WK, et al: Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma. Hepatology. 35:1164–1171. 2002. View Article : Google Scholar : PubMed/NCBI

28 

Llovet JM and Bruix J: Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization improves survival. Hepatology. 37:429–442. 2003. View Article : Google Scholar

29 

Barber FD, Mavligit G and Kurzrock R: Hepatic arterial infusion chemotherapy for metastatic colorectal cancer: a concise overview. Cancer Treat Rev. 30:425–436. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Wallace S, Carrasco CH, Charnsangavej C, Richli WR, Wright K and Gianturco C: Hepatic artery infusion and chemoembolization in the management of liver metastases. Cardiovasc Intervent Radiol. 13:153–160. 1990. View Article : Google Scholar : PubMed/NCBI

31 

Vogl TJ, Gruber T, Balzer JO, Eichler K, Hammerstingl R and Zangos S: Repeated transarterial chemoembolization in the treatment of liver metastases of colorectal cancer: prospective study. Radiology. 250:281–289. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Martin RC, Robbins K, Tomalty D, et al: Transarterial chemoembolisation (TACE) using irinotecan-loaded beads for the treatment of unresectable metastases to the liver in patients with colorectal cancer: an interim report. World J Surg Oncol. 7:802009. View Article : Google Scholar

33 

Pfizer: Camptosar® - irinotecan hydrochloride injection. Prescribing information (US), 2008.

34 

de Forni M, Bugat R, Chabot GG, et al: Phase I and pharmacokinetic study of the camptothecin derivative irinotecan, administered on a weekly schedule in cancer patients. Cancer Res. 54:4347–4354. 1994.PubMed/NCBI

35 

Pazdur R: Irinotecan: toward clinical end points in drug development. Oncology (Williston Park). 12:13–21. 1998.

36 

Lencioni R, Malagari K, Vogl T, et al: A randomized phase II trial of a drug eluting bead in the treatment of hepatocellular carcinoma by transcatheter arterial chemoembolization. In: Proc ASCO Annual Meeting. ASCO GI; Alexandria, VA. 2009

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Copy and paste a formatted citation
Spandidos Publications style
Eichler K, Zangos S, Mack MG, Hammerstingl R, Gruber-Rouh T, Gallus C and Vogl TJ: First human study in treatment of unresectable liver metastases from colorectal cancer with irinotecan-loaded beads (DEBIRI). Int J Oncol 41: 1213-1220, 2012.
APA
Eichler, K., Zangos, S., Mack, M.G., Hammerstingl, R., Gruber-Rouh, T., Gallus, C., & Vogl, T.J. (2012). First human study in treatment of unresectable liver metastases from colorectal cancer with irinotecan-loaded beads (DEBIRI). International Journal of Oncology, 41, 1213-1220. https://doi.org/10.3892/ijo.2012.1572
MLA
Eichler, K., Zangos, S., Mack, M. G., Hammerstingl, R., Gruber-Rouh, T., Gallus, C., Vogl, T. J."First human study in treatment of unresectable liver metastases from colorectal cancer with irinotecan-loaded beads (DEBIRI)". International Journal of Oncology 41.4 (2012): 1213-1220.
Chicago
Eichler, K., Zangos, S., Mack, M. G., Hammerstingl, R., Gruber-Rouh, T., Gallus, C., Vogl, T. J."First human study in treatment of unresectable liver metastases from colorectal cancer with irinotecan-loaded beads (DEBIRI)". International Journal of Oncology 41, no. 4 (2012): 1213-1220. https://doi.org/10.3892/ijo.2012.1572
Copy and paste a formatted citation
x
Spandidos Publications style
Eichler K, Zangos S, Mack MG, Hammerstingl R, Gruber-Rouh T, Gallus C and Vogl TJ: First human study in treatment of unresectable liver metastases from colorectal cancer with irinotecan-loaded beads (DEBIRI). Int J Oncol 41: 1213-1220, 2012.
APA
Eichler, K., Zangos, S., Mack, M.G., Hammerstingl, R., Gruber-Rouh, T., Gallus, C., & Vogl, T.J. (2012). First human study in treatment of unresectable liver metastases from colorectal cancer with irinotecan-loaded beads (DEBIRI). International Journal of Oncology, 41, 1213-1220. https://doi.org/10.3892/ijo.2012.1572
MLA
Eichler, K., Zangos, S., Mack, M. G., Hammerstingl, R., Gruber-Rouh, T., Gallus, C., Vogl, T. J."First human study in treatment of unresectable liver metastases from colorectal cancer with irinotecan-loaded beads (DEBIRI)". International Journal of Oncology 41.4 (2012): 1213-1220.
Chicago
Eichler, K., Zangos, S., Mack, M. G., Hammerstingl, R., Gruber-Rouh, T., Gallus, C., Vogl, T. J."First human study in treatment of unresectable liver metastases from colorectal cancer with irinotecan-loaded beads (DEBIRI)". International Journal of Oncology 41, no. 4 (2012): 1213-1220. https://doi.org/10.3892/ijo.2012.1572
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