Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
November 2012 Volume 41 Issue 5

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November 2012 Volume 41 Issue 5

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Therapeutic antitumor efficacy of anti-epidermal growth factor receptor antibody, cetuximab, against malignant pleural mesothelioma

  • Authors:
    • Jun Kurai
    • Hiroki Chikumi
    • Kiyoshi Hashimoto
    • Miyako Takata
    • Takanori Sako
    • Kosuke Yamaguchi
    • Naoki Kinoshita
    • Masanari Watanabe
    • Hirokazu Touge
    • Haruhiko Makino
    • Tadashi Igishi
    • Hironobu Hamada
    • Seiji Yano
    • Eiji Shimizu
  • View Affiliations / Copyright

    Affiliations: Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago-shi, Tottori-ken 683-8504, Japan, Graduate School of Health Sciences, Hiroshima University, Minami-ku, Hiroshima 734-8553, Japan, Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa 920-0934, Japan
    Copyright: © Kurai et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 1610-1618
    |
    Published online on: August 24, 2012
       https://doi.org/10.3892/ijo.2012.1607
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Epidermal growth factor receptor (EGFR) is commonly overexpressed in malignant pleural mesothelioma (MPM). Cetuximab is a chimeric mouse-human antibody targeted against EGFR and induces potent antibody-dependent cellular cytotoxicity (ADCC). The action of cetuximab against MPM cells has not been well studied. Therefore, in this study, we investigated the antitumor activity of cetuximab against MPM cell lines, particularly with respect to ADCC activity in vitro and in vivo. EGFR expression of MPM cells was measured by a quantitative flow cytometric analysis and immunohistochemistry. The effect of cetuximab on growth inhibition was assessed using a modified MTT assay. The ADCC activity was measured by a 4-h 51Cr release assay using fresh or IL-2-activated peripheral blood mononuclear cells. In vivo antitumor activity of cetuximab was evaluated using an orthotopic implantation mouse model. Cetuximab-mediated ADCC activity against MPM cells was observed at low concentration (0.25 mg/ml) and was enhanced by IL-2, whereas no direct effect on growth inhibition was detected. A logarithmic correlation was observed between the number of EGFRs on MPM cells and ADCC activity. Low EGFR expression on the MPM cells, which was weakly detectable by immunohistochemistry, was sufficient for maximum ADCC activity. In the mouse model, cetuximab treatment with or without IL-2 significantly inhibited intrathoracic tumor growth and prolonged their survival. Our study shows that cetuximab has potent anti-MPM activity both in vitro and in vivo, mainly through the immunologic mechanism of ADCC. Cetuximab has the potential to be used as a novel therapy for MPM patients.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1. 

L GreillierP AstoulMesothelioma and asbestos-related pleural diseasesRespiration76115200810.1159/00012757718583923

2. 

JC WagnerCA SleggsP MarchandDiffuse pleural mesothelioma and asbestos exposure in the North Western Cape ProvinceBr J Ind Med17260271196013782506

3. 

P DumortierL CopluV de MaertelaerS EmriI BarisP De VuystAssessment of environmental asbestos exposure in Turkey by bronchoalveolar lavageAm J Respir Crit Care Med15818151824199810.1164/ajrccm.158.6.97121199847273

4. 

B BarisAU DemirV ShehuY KarakocaG KisacikYI BarisEnvironmental fibrous zeolite (erionite) exposure and malignant tumors other than mesotheliomaJ Environ Pathol Toxicol Oncol1518318919969216804

5. 

P RuffieR FeldS MinkinDiffuse malignant mesothelioma of the pleura in Ontario and Quebec: a retrospective study of 332 patientsJ Clin Oncol71157116819892666592

6. 

HI PassK KrandaBK TemeckI FeuersteinSM SteinbergSurgically debulked malignant pleural mesothelioma: results and prognostic factorsAnn Surg Oncol4215222199710.1007/BF023066139142382

7. 

VW RuschS PiantadosiEC HolmesThe role of extra-pleural pneumonectomy in malignant pleural mesothelioma. A Lung Cancer Study Group trialJ Thorac Cardiovasc Surg1021919912072706

8. 

NJ VogelzangJJ RusthovenJ SymanowskiPhase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesotheliomaJ Clin Oncol2126362644200310.1200/JCO.2003.11.13612860938

9. 

PA JanneML TaffaroR SalgiaBE JohnsonInhibition of epidermal growth factor receptor signaling in malignant pleural mesotheliomaCancer Res6252425247200212234991

10. 

CL ArteagaEpidermal growth factor receptor dependence in human tumors: more than just expression?Oncologist7Suppl 43139200210.1634/theoncologist.7-suppl_4-3112202786

11. 

J BrabenderKD DanenbergR MetzgerEpidermal growth factor receptor and HER2-neu mRNA expression in non-small cell lung cancer is correlated with survivalClin Cancer Res718501855200111448895

12. 

A DestroGL CeresoliM FalleniEGFR overexpression in malignant pleural mesothelioma. An immunohistochemical and molecular study with clinico-pathological correlationsLung Cancer51207215200610.1016/j.lungcan.2005.10.01616384623

13. 

K OkudaH SasakiO KawanoEpidermal growth factor receptor gene mutation, amplification and protein expression in malignant pleural mesotheliomaJ Cancer Res Clin Oncol13411051111200810.1007/s00432-008-0384-418392851

14. 

LL GarlandC RankinDR GandaraPhase II study of erlotinib in patients with malignant pleural mesothelioma: a Southwest Oncology Group StudyJ Clin Oncol2524062413200710.1200/JCO.2006.09.763417557954

15. 

V AgarwalMJ LindL CawkwellTargeted epidermal growth factor receptor therapy in malignant pleural mesothelioma: where do we stand?Cancer Treat Rev37533542201010.1016/j.ctrv.2010.11.004

16. 

ES KimV HirshT MokGefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): a randomised phase III trialLancet37218091818200810.1016/S0140-6736(08)61758-419027483

17. 

FA ShepherdJ Rodrigues PereiraT CiuleanuErlotinib in previously treated non-small-cell lung cancerN Engl J Med353123132200510.1056/NEJMoa05075316014882

18. 

J AlbanellJ Codony-ServatF RojoActivated extracellular signal-regulated kinases: association with epidermal growth factor receptor/transforming growth factor alpha expression in head and neck squamous carcinoma and inhibition by anti-epidermal growth factor receptor treatmentsCancer Res61650065102001

19. 

NI GoldsteinM PrewettK ZuklysP RockwellJ MendelsohnBiological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft modelClin Cancer Res11311131819959815926

20. 

DJ JonkerCJ O’CallaghanCS KarapetisCetuximab for the treatment of colorectal cancerN Engl J Med35720402048200710.1056/NEJMoa07183418003960

21. 

R GovindanRA KratzkeJE Herndon IIGefitinib in patients with malignant mesothelioma: a phase II study by the Cancer and Leukemia Group BClin Cancer Res1123002304200510.1158/1078-0432.CCR-04-194015788680

22. 

S LiKR SchmitzPD JeffreyJJ WiltziusP KussieKM FergusonStructural basis for inhibition of the epidermal growth factor receptor by cetuximabCancer Cell7301311200510.1016/j.ccr.2005.03.00315837620

23. 

JD SatoT KawamotoAD LeJ MendelsohnJ PolikoffGH SatoBiological effects in vitro of monoclonal antibodies to human epidermal growth factor receptorsMol Biol Med151152919836094961

24. 

GN GillT KawamotoC CochetMonoclonal anti-epidermal growth factor receptor antibodies which are inhibitors of epidermal growth factor binding and antagonists of epidermal growth factor binding and antagonists of epidermal growth factor-stimulated tyrosine protein kinase activityJ Biol Chem259775577601984

25. 

T KawamotoJD SatoA LeJ PolikoffGH SatoJ MendelsohnGrowth stimulation of A431 cells by epidermal growth factor: identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibodyProc Natl Acad Sci USA8013371341198310.1073/pnas.80.5.1337

26. 

M NaramuraSD GilliesJ MendelsohnRA ReisfeldBM MuellerTherapeutic potential of chimeric and murine anti-(epidermal growth factor receptor) antibodies in a metastasis model for human melanomaCancer Immunol Immunother37343349199310.1007/BF015184588402738

27. 

J KuraiH ChikumiK HashimotoAntibody-dependent cellular cytotoxicity mediated by cetuximab against lung cancer cell linesClin Cancer Res1315521561200710.1158/1078-0432.CCR-06-172617332301

28. 

H KimuraK SakaiT AraoT ShimoyamaT TamuraK NishioAntibody-dependent cellular cytotoxicity of cetuximab against tumor cells with wild-type or mutant epidermal growth factor receptorCancer Sci9812751280200710.1111/j.1349-7006.2007.00510.x17498200

29. 

CS HenneyK KuribayashiDE KernS GillisInterleukin-2 augments natural killer cell activityNature291335338198110.1038/291335a06164929

30. 

Z LiuFT LeeN HanaiCytokine enhancement of in vitro antibody-dependent cellular cytotoxicity mediated by chimeric anti-GD3 monoclonal antibody KM871Cancer Immun213200212747758

31. 

QH NguyenRL RobertsBJ AnkSJ LinCK LauER StiehmEnhancement of antibody-dependent cellular cytotoxicity of neonatal cells by interleukin-2 (IL-2) and IL-12Clin Diagn Lab Immunol59810419989455889

32. 

E NakatakiS YanoY MatsumoriNovel orthotopic implantation model of human malignant pleural mesothelioma (EHMES-10 cells) highly expressing vascular endothelial growth factor and its receptorCancer Sci97183191200610.1111/j.1349-7006.2006.00163.x

33. 

GJ TodaroJE De LarcoGrowth factors produced by sarcoma virus-transformed cellsCancer Res38414741541978212188

34. 

CJ WikstrandRE McLendonAH FriedmanDD BignerCell surface localization and density of the tumor-associated variant of the epidermal growth factor receptor, EGFRvIIICancer Res574130414019979307304

35. 

G BrockhoffF HofstaedterR KnuechelFlow cytometric detection and quantitation of the epidermal growth factor receptor in comparison to Scatchard analysis in human bladder carcinoma cell linesCytometry177583199410.1002/cyto.9901701108001460

36. 

K DorshkindSB PollackMJ BosmaRA PhillipsNatural killer (NK) cells are present in mice with severe combined immunodeficiency (scid)J Immunol1343798380119853989296

37. 

FR LuoZ YangH DongCorrelation of pharmacokinetics with the antitumor activity of Cetuximab in nude mice bearing the GEO human colon carcinoma xenograftCancer Chemother Pharmacol56455464200510.1007/s00280-005-1022-315947929

38. 

R NiwaM SakuradaY KobayashiEnhanced natural killer cell binding and activation by low-fucose IgG1 antibody results in potent antibody-dependent cellular cytotoxicity induction at lower antigen densityClin Cancer Res1123272336200510.1158/1078-0432.CCR-04-2263

39. 

N PrangS PreithnerK BrischweinCellular and complement-dependent cytotoxicity of Ep-CAM-specific monoclonal antibody MT201 against breast cancer cell linesBr J Cancer92342349200515655555

40. 

A RalletMJ FarouxS TheobaldEpidermal growth factor receptors in breast cancer: comparison of radioligand and immunocytochemical assaysAnticancer Res141417142119948067716

41. 

JG KlijnPM BernsPI SchmitzJA FoekensThe clinical significance of epidermal growth factor receptor (EGF-R) in human breast cancer: a review on 5232 patientsEndocr Rev1331719921313356

42. 

R KimmigD PfeifferH LandsmannH HeppQuantitative determination of the epidermal growth factor receptor in cervical cancer and normal cervical epithelium by 2-color flow cytometry: evidence for down-regulation in cervical cancerInt J Cancer74365373199710.1002/(SICI)1097-0215(19970822)74:4%3C365::AID-IJC1%3E3.0.CO;2-T

43. 

KA SmithInterleukin-2: inception, impact, and implicationsScience24011691176198810.1126/science.31318763131876

44. 

E HooijbergJJ SeinPC van den BerkEradication of large human B cell tumors in nude mice with unconjugated CD20 monoclonal antibodies and interleukin 2Cancer Res552627263419957540106

45. 

J GolayM ManganiniV FacchinettiRituximab-mediated antibody-dependent cellular cytotoxicity against neoplastic B cells is stimulated strongly by interleukin-2Haematologica8810021012200312969808

46. 

M KuboT MorisakiH KurokiCombination of adoptive immunotherapy with Herceptin for patients with HER2-expressing breast cancerAnticancer Res2344434449200314666732

47. 

WE CarsonR PariharMJ LindemannInterleukin-2 enhances the natural killer cell response to Herceptin-coated Her2/neu-positive breast cancer cellsEur J Immunol3130163025200110.1002/1521-4141(2001010)31:10%3C3016::AID-IMMU3016%3E3.0.CO;2-J11592078

48. 

K KonoA TakahashiF IchiharaH SugaiH FujiiY MatsumotoImpaired antibody-dependent cellular cytotoxicity mediated by herceptin in patients with gastric cancerCancer Res6258135817200212384543

49. 

AD SantinS BelloneM GokdenOverexpression of HER-2/neu in uterine serous papillary cancerClin Cancer Res812711279200212006548

50. 

N BerinsteinR LevyTreatment of a murine B cell lymphoma with monoclonal antibodies and IL-2J Immunol13997197619873496394

51. 

WM VuistF v BuitenenMA de RieA HekmanP RumkeCJ MeliefPotentiation by interleukin 2 of Burkitt’s lymphoma therapy with anti-pan B (anti-CD19) monoclonal antibodies in a mouse xenotransplantation modelCancer Res49378337881989

52. 

WL GluckD HurstA YuenPhase I studies of interleukin (IL)-2 and rituximab in B-cell non-Hodgkin’s lymphoma: IL-2 mediated natural killer cell expansion correlations with clinical responseClin Cancer Res10225322642004

53. 

GF FlemingNJ MeropolGL RosnerA phase I trial of escalating doses of trastuzumab combined with daily subcutaneous interleukin 2: report of cancer and leukemia group B 9661Clin Cancer Res837183727200212473581

54. 

T RepkaEG ChioreanJ GayTrastuzumab and inter-leukin-2 in HER2-positive metastatic breast cancer: a pilot studyClin Cancer Res924402446200312855616

55. 

M SuzukiM Kato-NakanoS KawamotoTherapeutic antitumor efficacy of monoclonal antibody against Claudin-4 for pancreatic and ovarian cancersCancer Sci10016231630200910.1111/j.1349-7006.2009.01239.x19555390

56. 

DE Lopes de MenezesK Denis-MizeY TangRecombinant interleukin-2 significantly augments activity of rituximab in human tumor xenograft models of B-cell non-Hodgkin lymphomaJ Immunother306474200717198084

57. 

JM RodaT JoshiJP ButcharThe activation of natural killer cell effector functions by cetuximab-coated, epidermal growth factor receptor positive tumor cells is enhanced by cytokinesClin Cancer Res1364196428200710.1158/1078-0432.CCR-07-086517962339

58. 

T AzizA JilaihawiD PrakashThe management of malignant pleural mesothelioma; single centre experience in 10 yearsEur J Cardiothorac Surg22298305200212142203

59. 

O MonneuseAC BeaujardB GuibertLong-term results of intrathoracic chemohyperthermia (ITCH) for the treatment of pleural malignanciesBr J Cancer8818391843200310.1038/sj.bjc.660100012799624

60. 

H SchouwinkET RutgersJ van der SijpIntraoperative photodynamic therapy after pleuropneumonectomy in patients with malignant pleural mesothelioma: dose finding and toxicity resultsChest12011671174200110.1378/chest.120.4.1167

61. 

W Den OtterJJ JacobsJJ BattermannLocal therapy of cancer with free IL-2Cancer Immunol Immunother57931950200818256831

62. 

B CastagnetoS ZaiL MuttiPalliative and therapeutic activity of IL-2 immunotherapy in unresectable malignant pleural mesothelioma with pleural effusion: results of a phase II study on 31 consecutive patientsLung Cancer31303310200110.1016/S0169-5002(00)00192-6

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kurai J, Chikumi H, Hashimoto K, Takata M, Sako T, Yamaguchi K, Kinoshita N, Watanabe M, Touge H, Makino H, Makino H, et al: Therapeutic antitumor efficacy of anti-epidermal growth factor receptor antibody, cetuximab, against malignant pleural mesothelioma. Int J Oncol 41: 1610-1618, 2012.
APA
Kurai, J., Chikumi, H., Hashimoto, K., Takata, M., Sako, T., Yamaguchi, K. ... Shimizu, E. (2012). Therapeutic antitumor efficacy of anti-epidermal growth factor receptor antibody, cetuximab, against malignant pleural mesothelioma. International Journal of Oncology, 41, 1610-1618. https://doi.org/10.3892/ijo.2012.1607
MLA
Kurai, J., Chikumi, H., Hashimoto, K., Takata, M., Sako, T., Yamaguchi, K., Kinoshita, N., Watanabe, M., Touge, H., Makino, H., Igishi, T., Hamada, H., Yano, S., Shimizu, E."Therapeutic antitumor efficacy of anti-epidermal growth factor receptor antibody, cetuximab, against malignant pleural mesothelioma". International Journal of Oncology 41.5 (2012): 1610-1618.
Chicago
Kurai, J., Chikumi, H., Hashimoto, K., Takata, M., Sako, T., Yamaguchi, K., Kinoshita, N., Watanabe, M., Touge, H., Makino, H., Igishi, T., Hamada, H., Yano, S., Shimizu, E."Therapeutic antitumor efficacy of anti-epidermal growth factor receptor antibody, cetuximab, against malignant pleural mesothelioma". International Journal of Oncology 41, no. 5 (2012): 1610-1618. https://doi.org/10.3892/ijo.2012.1607
Copy and paste a formatted citation
x
Spandidos Publications style
Kurai J, Chikumi H, Hashimoto K, Takata M, Sako T, Yamaguchi K, Kinoshita N, Watanabe M, Touge H, Makino H, Makino H, et al: Therapeutic antitumor efficacy of anti-epidermal growth factor receptor antibody, cetuximab, against malignant pleural mesothelioma. Int J Oncol 41: 1610-1618, 2012.
APA
Kurai, J., Chikumi, H., Hashimoto, K., Takata, M., Sako, T., Yamaguchi, K. ... Shimizu, E. (2012). Therapeutic antitumor efficacy of anti-epidermal growth factor receptor antibody, cetuximab, against malignant pleural mesothelioma. International Journal of Oncology, 41, 1610-1618. https://doi.org/10.3892/ijo.2012.1607
MLA
Kurai, J., Chikumi, H., Hashimoto, K., Takata, M., Sako, T., Yamaguchi, K., Kinoshita, N., Watanabe, M., Touge, H., Makino, H., Igishi, T., Hamada, H., Yano, S., Shimizu, E."Therapeutic antitumor efficacy of anti-epidermal growth factor receptor antibody, cetuximab, against malignant pleural mesothelioma". International Journal of Oncology 41.5 (2012): 1610-1618.
Chicago
Kurai, J., Chikumi, H., Hashimoto, K., Takata, M., Sako, T., Yamaguchi, K., Kinoshita, N., Watanabe, M., Touge, H., Makino, H., Igishi, T., Hamada, H., Yano, S., Shimizu, E."Therapeutic antitumor efficacy of anti-epidermal growth factor receptor antibody, cetuximab, against malignant pleural mesothelioma". International Journal of Oncology 41, no. 5 (2012): 1610-1618. https://doi.org/10.3892/ijo.2012.1607
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team