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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
November 2012 Volume 41 Issue 5

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Journal Metrics

Impact Factor: 4.9

CiteScore: 8.9

CiteScore Rank: Q1: #66/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Review Open Access

Telomere structure and telomerase in health and disease (Review)

Daniel E. Gomez, Romina G. Armando, Hernán G. Farina, Pablo Lorenzano Menna, Carolina S. Cerrudo, P. Daniel Ghiringhelli, Daniel F. Alonso
Pages: 1561-1569
Published online on: 29 August 2012

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Article Open Access

Clonal dominance of CD133+ subset population as risk factor in tumor progression and disease recurrence of human cutaneous melanoma

Bhuvnesh K. Sharma, V. Manglik, Michael O'Connell, Ashani Weeraratna, Edward C. McCarron, Jennifer N. Broussard, Kyle A. Divito, Cynthia M. Simbulan-Rosenthal, Dean S. Rosenthal, John L. Zapas
Pages: 1570-1576
Published online on: 17 August 2012

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Article Open Access

STAT3 signal transduction through interleukin-22 in oral squamous cell carcinoma

Lutfun Naher, Tamotsu Kiyoshima, Ieyoshi Kobayashi, Hiroko Wada, Kengo  Nagata, Hiroaki  Fujiwara, Yukiko F. Ookuma, Satoru Ozeki, Seiji Nakamura, Hidetaka  Sakai
Pages: 1577-1586
Published online on: 21 August 2012

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Article Open Access

Epidermal growth factor induces bladder cancer cell proliferation through activation of the androgen receptor

Koji Izumi, Yichun Zheng, Yi Li, Jacqueline Zaengle, Hiroshi Miyamoto
Pages: 1587-1592
Published online on: 21 August 2012

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Article Open Access

Evaluation of changes in the tumor microenvironment after sorafenib therapy by sequential histology and 18F-fluoromisonidazole hypoxia imaging in renal cell carcinoma

Masahiro Murakami, Songji Zhao, Yan Zhao, Nusrat Fatema Chowdhury, Wenwen Yu, Ken-Ichi Nishijima, Mitsuyoshi Takiguchi, Nagara Tamaki, Yuji Kuge
Pages: 1593-1600
Published online on: 10 September 2012

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Article Open Access

Phase I/II study of immunotherapy using tumor antigen-pulsed dendritic cells in patients with hepatocellular carcinoma

Fujimasa Tada, Masanori Abe, Masashi Hirooka, Yoshiou Ikeda, Yoichi Hiasa, Yoon  Lee, Nam-Chul Jung, Woo-Bok Lee, Hyun-Soo Lee, Yong-Soo Bae, Morikazu Onji
Pages: 1601-1609
Published online on: 11 September 2012

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Article Open Access

Therapeutic antitumor efficacy of anti-epidermal growth factor receptor antibody, cetuximab, against malignant pleural mesothelioma

Jun Kurai, Hiroki Chikumi, Kiyoshi Hashimoto, Miyako Takata, Takanori Sako, Kosuke Yamaguchi, Naoki Kinoshita, Masanari Watanabe, Hirokazu Touge, Haruhiko Makino, Tadashi Igishi, Hironobu Hamada, Seiji Yano, Eiji Shimizu
Pages: 1610-1618
Published online on: 24 August 2012

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Article Open Access

Novel BRCA1 and BRCA2 pathogenic mutations in Slovene hereditary breast and ovarian cancer families

Srdjan Novaković, Maša Milatović, Petra Cerkovnik, Vida Stegel, Mateja Krajc, Marko Hočevar, Janez Žgajnar, Aleš Vakselj
Pages: 1619-1627
Published online on: 21 August 2012

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Article Open Access

The novel resveratrol analogue HS-1793 induces apoptosis via the mitochondrial pathway in murine breast cancer cells

Hyoun-Ji Kim, Kwang-Mo Yang, Yoo-Soo Park, Yoo-Jin Choi, Ji-Hyeon Yun, Cheol-Hun Son, Hong-Suk Suh, Min-Ho Jeong, Wol-Soon Jo
Pages: 1628-1634
Published online on: 31 August 2012

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Article

Inhibitory effects of Yangzheng Xiaoji on angiogenesis and the role of the focal adhesion kinase pathway

Wen G. Jiang, Lin Ye, Ke Ji, Natasha Frewer, Jiafu Ji, Malcolm D. Mason
Pages: 1635-1642
Published online on: 11 September 2012

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Article

Clinical significance of LGR5 and CD44 expression in locally advanced rectal cancer after preoperative chemoradiotherapy

Susumu Saigusa, Yasuhiro Inoue, Koji Tanaka, Yuji Toiyama, Kohei Matsushita, Mikio Kawamura, Yoshinaga Okugawa, Junichiro Hiro, Keiichi Uchida, Yasuhiko Mohri, Masato Kusunoki
Pages: 1643-1652
Published online on: 22 August 2012

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Article

miR-203 inhibits the migration and invasion of esophageal squamous cell carcinoma by regulating LASP1

Nobuyoshi Takeshita, Mikito Mori, Masayuki Kano, Isamu Hoshino, Yasunori Akutsu, Naoyuki Hanari, Yasuo Yoneyama, Norimasa Ikeda, Yuka Isozaki, Tetsurou Maruyama, Naoki Akanuma, Yukimasa Miyazawa, Hisahiro Matsubara
Pages: 1653-1661
Published online on: 30 August 2012

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Article

Development of a unique mouse model for pancreatic cancer lymphatic metastasis

Jiang Long, Guopei Luo, Chen Liu, Xiaobo Cui, Kei Satoh, Zhiwen Xiao, Bo Zhang, Jin Xu, Quanxing Ni, Min Li, Xianjun Yu
Pages: 1662-1668
Published online on: 30 August 2012

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Article

Chronic treatment with ginsenoside Rg3 induces Akt-dependent senescence in human glioma cells

Seong Sin, Sung Young Kim, Sung Su Kim
Pages: 1669-1674
Published online on: 23 August 2012

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Article

Differential gene expression pattern in early gastric cancer by an integrative systematic approach

Seungyoon Nam, Jieun Lee, Sung-Ho Goh, Seung-Hyun Hong, Naaleum Song, Sang-Geun Jang, Il Ju Choi, Yeon-Su Lee
Pages: 1675-1682
Published online on: 06 September 2012

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Article

AKT serine/threonine protein kinase modulates bufalin-triggered intrinsic pathway of apoptosis in CAL 27 human oral cancer cells

Shih-Chang Tsai, Chi-Cheng Lu, Chao-Ying Lee, Yung-Chang Lin, Jing-Gung Chung, Sheng-Chu Kuo, Sakae Amagaya, Fei-Na Chen, Michael Yuanchien Chen, Shih-Feng Chan, Jai-Sing Yang
Pages: 1683-1692
Published online on: 23 August 2012

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Article

Glioblastoma cell line-derived spheres in serum‑containing medium versus serum-free medium: A comparison of cancer stem cell properties

Xin Hong, Khalil Chedid, Steven N. Kalkanis
Pages: 1693-1700
Published online on: 21 August 2012

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Article

Oncogenic features of the JMJD2A histone demethylase in breast cancer

William L. Berry, Sook Shin, Stan A. Lightfoot, Ralf Janknecht
Pages: 1701-1706
Published online on: 04 September 2012

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Article

Inhibition of hedgehog signaling depresses self-renewal of pancreatic cancer stem cells and reverses chemoresistance

Feng-Ting Huang, Yong-Xun Zhuan-Sun, Yan-Yan Zhuang, Shu-Li Wei, Jian Tang, Wen-Bo Chen, Shi-Neng Zhang
Pages: 1707-1714
Published online on: 22 August 2012

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Article

Anticancer effects of KI-10F: A novel compound affecting apoptosis, angiogenesis and cell growth in colon cancer

Sang-Won Hong, Kyung Hee Jung, Myung-Joo Choi, Da Young Kim, Hee‑Seung Lee, Hong-Mei Zheng, Guang Yong Li, Ibrahim  M. El‑Deeb, Byung Sun Park, So Ha Lee, Soon-Sun Hong
Pages: 1715-1722
Published online on: 27 August 2012

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Article

RL66 a second-generation curcumin analog has potent in vivo and in vitro anticancer activity in ER‑negative breast cancer models

Babasaheb Yadav, Sebastien Taurin, Lesley Larsen, Rhonda J. Rosengren
Pages: 1723-1732
Published online on: 11 September 2012

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Article

Upregulation and inhibition of the nuclear translocation of Oct4 during multistep gastric carcinogenesis

Fathyia Y. Al-Marzoqee, Ghalia Khoder, Haifa Al-Awadhi, Rony John, Azam Beg, Aron Vincze, Frank Branicki, Sherif M. Karam
Pages: 1733-1743
Published online on: 24 August 2012

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Article

Induction of LGR5 by H2O2 treatment is associated with cell proliferation via the JNK signaling pathway in colon cancer cells

Sung-Hee Kim, Kyung-Hee Kim, Byong-Chul Yoo, Ja-Lok Ku
Pages: 1744-1750
Published online on: 22 August 2012

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Article

Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutations

Fabrizio Galimberti, Alexander M. Busch, Fadzai Chinyengetere, Tian Ma, David Sekula, Vincent A. Memoli, Konstantin H. Dragnev, Fang Liu, Kevin C. Johnson, Yongli Guo, Sarah J. Freemantle, Angeline S. Andrew, Patricia Greninger, David J. Robbins, Jeff Settleman, Cyril Benes, Ethan Dmitrovsky
Pages: 1751-1761
Published online on: 22 August 2012

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Article

Suppression of lymphangiogenesis in human lymphatic endothelial cells by simultaneously blocking VEGF-C and VEGF-D/VEGFR-3 with norcantharidin

Zhong-Yan Liu, Hai-Ou Qiu, Xiao-Jian Yuan, Yan-Yan Ni, Jian-Jun Sun, Wei Jing, Yue-Zu Fan
Pages: 1762-1772
Published online on: 23 August 2012

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Article

Notch1 activation contributes to tumor cell growth and proliferation in human hepatocellular carcinoma HepG2 and SMMC7721 cells

Juan Gao, Yongqiang Dong, Bicheng Zhang, Yimin Xiong, Weitian Xu, Yi Cheng, Meng Dai, Zhao Yu, Hualin Xu, Guorong Zheng
Pages: 1773-1781
Published online on: 24 August 2012

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Article

GSK3β signaling is involved in ultraviolet B-induced activation of autophagy in epidermal cells

Yang Yang, Haiping Wang, Siying Wang, Mei Xu, Mei Liu, Mingjun Liao, Jacqueline A. Frank, Sabal Adhikari, Kimberly A. Bower, Xianglin Shi, Cuiling Ma, Jia Luo
Pages: 1782-1788
Published online on: 05 September 2012

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Article

The anticancer effects of Saccharina japonica on 267B1/K-ras human prostate cancer cells

Mi Jeong Jo, Hyung Rak Kim, Gun Do Kim
Pages: 1789-1797
Published online on: 30 August 2012

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Article

Antitumor activity of AZ64 via G2/M arrest in non-small cell lung cancer

Yuwen Xue, Hening Ren, Wei Xiao, Zuoming Chu, J. Jack Lee, Li Mao
Pages: 1798-1808
Published online on: 04 September 2012

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Article

Adenovirus-mediated overexpression of BMP-9 inhibits human osteosarcoma cell growth and migration through downregulation of the PI3K/AKT pathway Corrigendum in /10.3892/ijo.2016.3714

Bo Li, Yuehua Yang, Shengdan Jiang, Binbin Ni, Ke Chen, Leisheng Jiang
Pages: 1809-1819
Published online on: 04 September 2012

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Article

KP-CoT-23 (CCDC83) is a novel immunogenic cancer/testis antigen in colon cancer

Myung-Ha Song, Jin-Mok Ha, Dong-Hoon Shin, Chang‑Hun  Lee, Lloyd Old, Sang-Yull Lee
Pages: 1820-1826
Published online on: 22 August 2012

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Article

Hypoxia increases CX3CR1 expression via HIF-1 and NF‑κB in androgen-independent prostate cancer cells

Li-Jie Xiao, Yuan-Yuan Chen, Ping Lin, Hai-Feng Zou, Feng Lin, Li-Nan Zhao, Dong Li, Liang Guo, Jie-Bing Tang, Xiu-Lan Zheng, Xiao-Guang Yu
Pages: 1827-1836
Published online on: 27 August 2012

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Article

Differential sensitivity to paclitaxel-induced apoptosis and growth suppression in paclitaxel-resistant cell lines established from HEC-1 human endometrial adenocarcinoma cells

Tetsuji Tanaka, Saori Toujima, Junko Tanaka
Pages: 1837-1844
Published online on: 22 August 2012

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Article

Inhibition of the AKT/mTOR and erbB pathways by gefitinib, perifosine and analogs of gonadotropin-releasing hormone I and II to overcome tamoxifen resistance in breast cancer cells

Martin Block, Carsten Gründker, Stefanie Fister, Julia Kubin, Ludwig Wilkens, Michael D. Mueller, Bernhard Hemmerlein, Günter Emons, Andreas R. Günthert
Pages: 1845-1854
Published online on: 21 August 2012

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Article

Combination therapy targeting Raf-1 and MEK causes apoptosis of HCT116 colon cancer cells

Romesh R. Subramanian, Akio Yamakawa
Pages: 1855-1862
Published online on: 22 August 2012

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Article

Carboplatin treatment of antiestrogen-resistant breast cancer cells

Mathilde S. Larsen, Christina W. Yde, Ib J. Christensen, Anne E. Lykkesfeldt
Pages: 1863-1870
Published online on: 06 September 2012

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Article

Cell-free microRNAs in urine as diagnostic and prognostic biomarkers of bladder cancer

Seok Joong Yun, Pildu Jeong, Won-Tae Kim, Tae Hwan Kim, Young-Suk Lee, Phil Hyun Song, Yung-Hyun Choi, Isaac Yi Kim, Sung-Kwon Moon, Wun-Jae Kim
Pages: 1871-1878
Published online on: 06 September 2012

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Article

Betaine inhibits in vitro and in vivo angiogenesis through suppression of the NF-κB and Akt signaling pathways

Eui-Yeun Yi, Yung-Jin Kim
Pages: 1879-1885
Published online on: 31 August 2012

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Retraction Open Access

[Retracted] Two initiation sites of early detection of colon cancer, revealed by localization of pERK1/2 in the nuclei or in aggregates at the perinuclear region of tumor cells

Abraham Amsterdam, Elias Shezen, Calanit Raanan, Letizia Schreiber, Yasmin Slilat, Yakov Fabrikant, Ehud Melzer, Rony Seger
Pages: 1887-1887
Published online on: 18 September 2012

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Retraction Open Access

[Retracted] Use of multiple biomarkers for the localization and characterization of colon cancer stem cells by indirect immunocytochemistry

Abraham Amsterdam, Calanit Raanan, Letizia Schreiber, Ora Freyhan, Yakov Fabrikant, Ehud Melzer
Pages: 1888-1888
Published online on: 18 September 2012

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Journal Cover
January-2026 Volume 68 Issue 1

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Journal Metrics

Impact Factor: 4.9

CiteScore: 8.9

CiteScore Rank: Q1: #66/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Article Open Access

c‑Myc‑regulated RPLP0 via the ROS‑mediated JAK2/STAT3 positive feedback loop facilitates hepatocellular carcinoma malignancy progression

Yanqiu Meng, Lebin Yuan, Gangrui Meng, Hongxiang Huang, Xianbin Huang, Xinping Xu, Xiaodong Peng
Article Number: 13
Published online on: 27 November 2025

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Review Open Access

Obesity, chronic breast inflammation and carcinogenesis: Molecular pathways and clinical implications (Review)

Fangying Li, Zhenhua Gao
Article Number: 12
Published online on: 27 November 2025

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Review Open Access

The tumor microenvironment in lung cancer: Heterogeneity, therapeutic resistance and emerging treatment strategies (Review)

Li Liu, Li Yang, Hongmin Li, Tianlu Shang, Lihan Liu
Article Number: 11
Published online on: 26 November 2025

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Article Open Access

Discovery of the late autophagy inhibitor FZU‑0045‑053 and its anti‑breast cancer and immunomodulatory effects

Jinlan Luo, Yi Yang, Lulu Cheng, Fangting Cheng, Huangwenlong Zhuang, Shanshan Chen, Panpan Qiao, Yinbin Liang, Li Chen, Yang Sun, Haijun Chen, Qinying Liu
Article Number: 10
Published online on: 26 November 2025

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Correction Open Access

[Corrigendum] RIPK4/PEBP1 axis promotes pancreatic cancer cell migration and invasion by activating RAF1/MEK/ERK signaling

Zi-Hao Qi, Hua-Xiang Xu, Shi-Rong Zhang, Jin-Zhi Xu, Shuo Li, He-Li Gao, Wei Jin, Wen-Quan Wang, Chun-Tao Wu, Quan-Xing Ni, Xian-Jun Yu, Liang Liu
Article Number: 9
Published online on: 24 November 2025

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Article Open Access

Ephrin‑B2 promotes gastric cancer growth by inhibiting apoptosis and regulating the cell cycle via the Wnt/β‑catenin signaling pathway

Ding Ding, Xiaoshan Wang, Ran Xuan, Rui Li, Yalu Zhang, Zhengguang Wang
Article Number: 8
Published online on: 18 November 2025

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Expression of Concern Open Access

[Expression of Concern] Gene therapy for human colorectal cancer cell lines with recombinant adenovirus 5 based on loss of the insulin‑like growth factor 2 imprinting

Huiling Sun, Yuqin Pan, Bangshun He, Qiwen Deng, Rui Li, Yeqiong Xu, Jie Chen, Tianyi Gao, Houqun Ying, Feng Wang, Xian Liu, Shukui Wang
Article Number: 7
Published online on: 18 November 2025

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Review Open Access

Ferroptosis in biliary tract cancer: Molecular mechanisms and therapeutic applications (Review)

Ruiqi Zou, Yushi Dai, Siqi Yang, Haijie Hu, Fuyu Li, Fei Liu
Article Number: 6
Published online on: 14 November 2025

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Expression of Concern Open Access

[Expression of Concern] Radiosensitization of esophageal carcinoma cells by knockdown of RNF2 expression

Xing-Xiao Yang, Ming Ma, Mei-Xiang Sang, Xue-Xiao Wang, Heng Song, Zhi-Kun Liu, Shu-Chai Zhu
Article Number: 5
Published online on: 10 November 2025

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Review Open Access

Targeting ferroptosis in Helicobacter pylori‑associated gastric cancer development: From molecular mechanisms to application prospects (Review)

Chen-Yi Wang, Meng-Hui Wang, Chuan Xie
Article Number: 4
Published online on: 05 November 2025

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Expression of Concern Open Access

[Expression of Concern] Leptin promotes breast cancer cell migration and invasion via IL‑18 expression and secretion

Kuangfa Li, Lan Wei, Yunxiu Huang, Yang Wu, Min Su, Xueli Pang, Nian Wang, Feihu Ji, Changli Zhong, Tingmei Chen
Article Number: 3
Published online on: 04 November 2025

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Review Open Access

Cancer immunotherapy strategies based on transition‑metal medical materials: Still a long way to go (Review)

Zhefei Du, Zhenyu Cao, Chao Fang, Daihan Xie, Lixin Xie, Chunxia Su, Yu Huo
Article Number: 2
Published online on: 04 November 2025

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Expression of Concern Open Access

[Expression of Concern] Regulation of NADPH oxidase (Nox2) by lipid rafts in breast carcinoma cells

Rama Rao Malla, Hari Raghu, Jasti S. Rao
Article Number: 1
Published online on: 23 October 2025

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Journal Cover
February-2026 Volume 68 Issue 2

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Journal Metrics

Impact Factor: 4.9

CiteScore: 8.9

CiteScore Rank: Q1: #66/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Retraction Open Access

[Retracted] Cdc42 expression in cervical cancer and its effects on cervical tumor invasion and migration

Hongnan Ye, Youyi Zhang, Li Geng, Zijian Li
Article Number: 20
Published online on: 05 December 2025

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Article Open Access

Regulation and reversal of paclitaxel resistance via the STAT1‑mediated apoptotic pathway in ovarian cancer

Fanchen Wang, Xiaolin Xu, Bin Guan, Xin Li, Jia Yuan, Wencai Guan, Junyu Chen, Jingyi Fang, Qi Lu, Guoxiong Xu
Article Number: 19
Published online on: 05 December 2025

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Review

Cancer stem cell heterogeneity‑inspired therapeutics for enhancing tumor treatment outcomes (Review)

Hanning Xu, Qunchao Si, Yongyao Song, Shengping Sun, Xianghong Wei, Hui Long, Xiaomei Wang
Article Number: 18
Published online on: 04 December 2025

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Review Open Access

Roles of interleukins in spasmolytic polypeptide‑expressing metaplasia (Review)

Jiale Ma, Tiancheng Zhan, Xinyuan Zhang, Wang Gao, Shuangmei Zhao, Huizhen Li
Article Number: 17
Published online on: 03 December 2025

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Expression of Concern Open Access

[Expression of Concern] MUC1 is a downstream target of STAT3 and regulates lung cancer cell survival and invasion

Jingchun Gao, Matthew J. Mcconnell, Bin Yu, Jiannong Li, Justin M. Balko, Esther P. Black, Joseph O. Johnson, Mark C. Lloyd, Soner Altiok, Eric B. Haura
Article Number: 16
Published online on: 03 December 2025

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Review Open Access

Emerging biomarkers in prostate cancer diagnosis and treatment: Insights into genetic, RNA and metabolic markers (Review)

Yuanshe Huang, Jingxin Mao, Xiaobing Li
Article Number: 15
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] GDC‑0152 attenuates the malignant progression of osteosarcoma promoted by ANGPTL2 via PI3K/AKT but not p38MAPK signaling pathway

Lin Yang, Taipengfei Shu, Yingjian Liang, Wenguang Gu, Chunlei Wang, Xuanhe Song, Changdong Fan, Wenbo Wang
Article Number: 14
Published online on: 01 December 2025

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