|
1.
|
Jemal A, Bray F, Center MM, Ferlay J, Ward
E and Forman D: Global cancer statistics. CA Cancer J Clin.
61:69–90. 2011. View Article : Google Scholar
|
|
2.
|
Kim M and Choe S: BMPs and their clinical
potentials. BMB Rep. 44:619–634. 2011. View Article : Google Scholar
|
|
3.
|
Boon MR, van der Horst G, van der Pluijm
G, et al: Bone morphogenetic protein 7: a broad-spectrum growth
factor with multiple target therapeutic potency. Cytokine Growth
Factor Rev. 22:221–229. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
4.
|
Gobbi G, Sangiorgi L, Lenzi L, et al:
Seven BMPs and all their receptors are simultaneously expressed in
osteosarcoma cells. Int J Oncol. 20:143–147. 2002.PubMed/NCBI
|
|
5.
|
Yoshikawa H, Nakase T, Myoui A and Ueda T:
Bone morphogenetic proteins in bone tumors. J Orthop Sci.
9:334–340. 2004. View Article : Google Scholar
|
|
6.
|
Sulzbacher I, Birner P, Trieb K,
Pichlbauer E and Lang S: The expression of bone morphogenetic
proteins in osteosarcoma and its relevance as a prognostic
parameter. J Clin Pathol. 55:381–385. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
7.
|
Sotobori T, Ueda T, Myoui A, et al: Bone
morphogenetic protein-2 promotes the haptotactic migration of
murine osteoblastic and osteosarcoma cells by enhancing
incorporation of integrin beta1 into lipid rafts. Exp Cell Res.
312:3927–3938. 2006. View Article : Google Scholar
|
|
8.
|
Weiss KR, Cooper GM, Jadlowiec JA, McGough
RL III and Huard J: VEGF and BMP expression in mouse osteosarcoma
cells. Clin Orthop Relat Res. 450:111–117. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
9.
|
Song JJ, Celeste AJ, Kong FM, Jirtle RL,
Rosen V and Thies RS: Bone morphogenetic protein-9 binds to liver
cells and stimulates proliferation. Endocrinology. 136:4293–4297.
1995.PubMed/NCBI
|
|
10.
|
Ploemacher RE, Engels LJ, Mayer AE, Thies
S and Neben S: Bone morphogenetic protein 9 is a potent synergistic
factor for murine hemopoietic progenitor cell generation and colony
formation in serum-free cultures. Leukemia. 13:428–437. 1999.
View Article : Google Scholar : PubMed/NCBI
|
|
11.
|
Helm GA, Alden TD, Beres EJ, et al: Use of
bone morphogenetic protein-9 gene therapy to induce spinal
arthrodesis in the rodent. J Neurosurg. 92:191–196. 2000.PubMed/NCBI
|
|
12.
|
López-Coviella I, Berse B, Krauss R, Thies
RS and Blusztajn JK: Induction and maintenance of the neuronal
cholinergic phenotype in the central nervous system by BMP-9.
Science. 289:313–316. 2000.
|
|
13.
|
Chen C, Grzegorzewski KJ, Barash S, et al:
An integrated functional genomics screening program reveals a role
for BMP-9 in glucose homeostasis. Nat Biotechnol. 21:294–301. 2003.
View Article : Google Scholar : PubMed/NCBI
|
|
14.
|
Truksa J, Peng H, Lee P and Beutler E:
Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1
expression independently of Hfe, transferrin receptor 2 (Tfr2), and
IL-6. Proc Natl Acad Sci USA. 103:10289–10293. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
15.
|
David L, Mallet C, Mazerbourg S, Feige JJ
and Bailly S: Identification of BMP9 and BMP10 as functional
activators of the orphan activin receptor-like kinase 1 (ALK1) in
endothelial cells. Blood. 109:1953–1961. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
16.
|
Brown MA, Zhao Q, Baker KA, et al: Crystal
structure of BMP-9 and functional interactions with pro-region and
receptors. J Biol Chem. 280:25111–25118. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
17.
|
Scharpfenecker M, van Dinther M, Liu Z, et
al: BMP-9 signals via ALK1 and inhibits hFGF-induced endothelial
cell proliferation and VEGF-stimulated angiogenesis. J Cell Sci.
120:964–972. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
18.
|
Upton PD, Davies RJ, Trembath RC and
Morrell NW: Bone morphogenetic protein (BMP) and activin type II
receptors balance BMP9 signals mediated by activin receptor-like
kinase-1 in human pulmonary artery endothelial cells. J Biol Chem.
284:15794–15804. 2009. View Article : Google Scholar
|
|
19.
|
Ye L, Kynaston H and Jiang WG: Bone
morphogenetic protein-9 induces apoptosis in prostate cancer cells,
the role of prostate apoptosis response-4. Mol Cancer Res.
6:1594–1606. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
20.
|
Hanahan D and Weinberg RA: Hallmarks of
cancer: the next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
21.
|
Yang LJ and Jin Y: Immunohistochemical
observation of bone morphogenetic protein in normal and abnormal
conditions. Clin Orthop Relat Res. 257:249–256. 1990.PubMed/NCBI
|
|
22.
|
Laiitnen M, Jortikka L, Halttunen T, et
al: Measurement of total and local bone morphogenetic protein
concentration in bone tumours. Int Orthop. 21:188–193. 1997.
View Article : Google Scholar : PubMed/NCBI
|
|
23.
|
Yoshikawa H, Shimizu K, Nakase T and
Takaoka K: Periosteal sunburst speculation in osteosarcoma. A
possible role for bone morphogenetic protein. Clin Orthop Relat
Res. 308:213–219. 1994.PubMed/NCBI
|
|
24.
|
Yoshikawa H, Retting WJ, Lane JM, et al:
Immunohistochemical detection of bone morphogenetic protein in bone
and soft-tissue sarcomas. Cancer. 74:842–847. 1994. View Article : Google Scholar : PubMed/NCBI
|
|
25.
|
Yoshikawa H, Retting WJ, Takaoka K, et al:
Expression of bone morphogenetic proteins in human osteosarcoma.
Immunohistochemical detection with monoclonal antibody. Cancer.
73:85–91. 1994. View Article : Google Scholar
|
|
26.
|
Bidart M, Ricard N, Levet S, et al: BMP9
is produced by hepatocytes and circulates mainly in an active
mature form complexed to its prodomain. Cell Mol Life Sci.
69:313–324. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
27.
|
Suzuki Y, Ohga N, Morishita Y, et al:
BMP-9 induces proliferation of multiple types of endothelial cells
in vitro and in vivo. J Cell Sci. 123:1684–1692. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
28.
|
Castonguay R, Werner ED, Matthews RG, et
al: Soluble endoglin specifically binds bone morphogenetic proteins
9 and 10 via its orphan domain, inhibits blood vessel formation,
and suppresses tumor growth. J Biol Chem. 286:30034–30046. 2011.
View Article : Google Scholar
|
|
29.
|
Herrera B, van Dinther M, Ten Dijke P and
Inman GJ: Autocrine bone morphogenetic protein-9 signals through
activin receptor-like kinase-2/Smad1/Smad4 to promote ovarian
cancer cell proliferation. Cancer Res. 69:9254–9262. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
30.
|
Hotfilder M, Sondermann P, Senss A, et al:
PI3K/AKT is involved in mediating survival signals that rescue
Ewing tumor cells from fibroblast growth factor 2-induced cell
death. Br J Cancer. 92:705–710. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
31.
|
Tsubaki M, Yamazoe Y, Yanae M, et al:
Blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathways by statins
reduces the expression of bFGF, HGF, and TGF-β as angiogenic
factors in mouse osteosarcoma. Cytokine. 54:100–107.
2011.PubMed/NCBI
|
|
32.
|
Jin S, Pang RP, Shen JN, et al: Grifolin
induces apoptosis via inhibition of PI3K/AKT signaling pathway in
human osteosarcoma cells. Apoptosis. 12:1317–1326. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
33.
|
Liu B, Shi ZL, Feng J and Tao HM:
Celecoxib, a cyclooxygenase-2 inhibitor, induces apoptosis in human
osteosarcoma cell line MG-63 via down-regulation of PI3K/Akt. Cell
Biol Int. 32:494–501. 2008. View Article : Google Scholar
|
|
34.
|
Wu Z, Min L, Chen D, et al: Overexpression
of BMI-1 promotes cell growth and resistance to cisplatin treatment
in osteosarcoma. PLoS One. 6:e146482011. View Article : Google Scholar : PubMed/NCBI
|
|
35.
|
Hernández-Rodríguez NA, Correa E, Sotelo
R, et al: Ki-67: a proliferative marker that may predict pulmonary
metastases and mortality of primary osteosarcoma. Cancer Detect
Prev. 25:210–215. 2001.PubMed/NCBI
|
|
36.
|
Loukopoulos P, O’Brien T, Ghoddusi M,
Mungall BA and Robinson WF: Characterization of three novel canine
osteosarcoma cell lines producing high levels of matrix
metal-loproteinases. Res Vet Sci. 77:131–141. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
37.
|
Cawston TE and Wilson AJ: Understanding
the role of tissue degrading enzymes and their inhibitors in
development and disease. Best Pract Res Clin Rheumatol.
20:983–1002. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
38.
|
Fu Y, Zhang Q, Kang C, et al: Inhibitory
effects of adenovirus mediated COX-2, Akt1 and PIK3R1 shRNA on the
growth of malignant tumor cells in vitro and in vivo.
Int J Oncol. 35:583–591. 2009.
|
