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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2012 Volume 41 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Article

Antitumor activity of AZ64 via G2/M arrest in non-small cell lung cancer

  • Authors:
    • Yuwen Xue
    • Hening Ren
    • Wei Xiao
    • Zuoming Chu
    • J. Jack Lee
    • Li Mao
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China, Department of Oncology and Diagnostic Sciences, University of Maryland Dental School, Baltimore, MD 21201, USA, Department of Thoracic Head __AMB__ Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA, Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
  • Pages: 1798-1808
    |
    Published online on: September 4, 2012
       https://doi.org/10.3892/ijo.2012.1619
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Abstract

AZ64 is a novel antitumor agent designed as a tropomyosin-related kinase (Trk) inhibitor; however, its effect on lung cancer and its mechanism of action remain unclear. This study aimed to elucidate the antitumor activity of AZ64 and its mechanism of action against non-small cell lung cancer (NSCLC). Our results demonstrate that AZ64 has a potent anti-proliferative effect on NSCLC cells and acts in a dose- and time-dependent manner. We also demonstrate that AZ64 suppresses the anchorage-independent growth and invasion of NSCLC cells. In vivo experiments demonstrated that AZ64 significantly reduced the tumor growth of NSCLC xenografts in nude mice and was well-tolerated. Mechanistic experiments revealed that AZ64 induced the G2/M arrest of NSCLC cells by the accumulation of phospho-cdc2 (Tyr15) at the G2/M transition, following the downregulation of Cdc25C expression. Collectively, our data demonstrate that AZ64 is a potential antitumor drug that may be used for the treatment of NSCLC, which functions by targeting the G2/M transition via the inhibition of the dephosphorylation of phospho-cdc2 (Tyr15).
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Copy and paste a formatted citation
Spandidos Publications style
Xue Y, Ren H, Xiao W, Chu Z, Lee JJ and Mao L: Antitumor activity of AZ64 via G2/M arrest in non-small cell lung cancer. Int J Oncol 41: 1798-1808, 2012.
APA
Xue, Y., Ren, H., Xiao, W., Chu, Z., Lee, J.J., & Mao, L. (2012). Antitumor activity of AZ64 via G2/M arrest in non-small cell lung cancer. International Journal of Oncology, 41, 1798-1808. https://doi.org/10.3892/ijo.2012.1619
MLA
Xue, Y., Ren, H., Xiao, W., Chu, Z., Lee, J. J., Mao, L."Antitumor activity of AZ64 via G2/M arrest in non-small cell lung cancer". International Journal of Oncology 41.5 (2012): 1798-1808.
Chicago
Xue, Y., Ren, H., Xiao, W., Chu, Z., Lee, J. J., Mao, L."Antitumor activity of AZ64 via G2/M arrest in non-small cell lung cancer". International Journal of Oncology 41, no. 5 (2012): 1798-1808. https://doi.org/10.3892/ijo.2012.1619
Copy and paste a formatted citation
x
Spandidos Publications style
Xue Y, Ren H, Xiao W, Chu Z, Lee JJ and Mao L: Antitumor activity of AZ64 via G2/M arrest in non-small cell lung cancer. Int J Oncol 41: 1798-1808, 2012.
APA
Xue, Y., Ren, H., Xiao, W., Chu, Z., Lee, J.J., & Mao, L. (2012). Antitumor activity of AZ64 via G2/M arrest in non-small cell lung cancer. International Journal of Oncology, 41, 1798-1808. https://doi.org/10.3892/ijo.2012.1619
MLA
Xue, Y., Ren, H., Xiao, W., Chu, Z., Lee, J. J., Mao, L."Antitumor activity of AZ64 via G2/M arrest in non-small cell lung cancer". International Journal of Oncology 41.5 (2012): 1798-1808.
Chicago
Xue, Y., Ren, H., Xiao, W., Chu, Z., Lee, J. J., Mao, L."Antitumor activity of AZ64 via G2/M arrest in non-small cell lung cancer". International Journal of Oncology 41, no. 5 (2012): 1798-1808. https://doi.org/10.3892/ijo.2012.1619
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