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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Article

Carboplatin treatment of antiestrogen-resistant breast cancer cells

  • Authors:
    • Mathilde S. Larsen
    • Christina W. Yde
    • Ib J. Christensen
    • Anne E. Lykkesfeldt
  • View Affiliations / Copyright

    Affiliations: Breast Cancer Group, Unit of Cell Death and Metabolism, Danish Cancer Society Research Center, DK-2100 Copenhagen Ø, Denmark, Finsen Laboratory, Rigshospitalet, DK-2200 Copenhagen, Denmark
  • Pages: 1863-1870
    |
    Published online on: September 6, 2012
       https://doi.org/10.3892/ijo.2012.1623
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Abstract

Antiestrogen resistance is a major clinical problem in current breast cancer treatment. Therefore, biomarkers and new treatment options for antiestrogen-resistant breast cancer are needed. In this study, we investigated whether antiestrogen‑resistant breast cancer cell lines have increased sensitivity to carboplatin, as it was previously shown with cisplatin, and whether low Bcl-2 expression levels have a potential value as marker for increased carboplatin sensitivity. Breast cancer cells resistant to the pure antiestrogen fulvestrant, and two out of four cell lines resistant to the antiestrogen tamoxifen, were more sensitive to carboplatin treatment compared to the parental MCF-7 cell line. This indicates that carboplatin may be an advantageous treatment in antiestrogen‑resistant breast cancer; however, a marker for increased sensitivity would be needed. Low Bcl-2 expression was correlated with increased carboplatin response in the tamoxifen‑resistant cell line MCF-7/TAMR-1 and overexpression of Bcl-2 in this cell line resulted in significantly reduced carboplatin sensitivity, confirming the anti-apoptotic role of Bcl-2. However, neither Bcl-2 expression alone, nor Bcl-2 in combination with Bcl-xL and Bax, could explain the observed responses to carboplatin in all tamoxifen‑resistant cell lines, indicating that more markers are needed to predict the response to carboplatin in tamoxifen‑resistant breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Larsen MS, Yde CW, Christensen IJ and Lykkesfeldt AE: Carboplatin treatment of antiestrogen-resistant breast cancer cells. Int J Oncol 41: 1863-1870, 2012.
APA
Larsen, M.S., Yde, C.W., Christensen, I.J., & Lykkesfeldt, A.E. (2012). Carboplatin treatment of antiestrogen-resistant breast cancer cells. International Journal of Oncology, 41, 1863-1870. https://doi.org/10.3892/ijo.2012.1623
MLA
Larsen, M. S., Yde, C. W., Christensen, I. J., Lykkesfeldt, A. E."Carboplatin treatment of antiestrogen-resistant breast cancer cells". International Journal of Oncology 41.5 (2012): 1863-1870.
Chicago
Larsen, M. S., Yde, C. W., Christensen, I. J., Lykkesfeldt, A. E."Carboplatin treatment of antiestrogen-resistant breast cancer cells". International Journal of Oncology 41, no. 5 (2012): 1863-1870. https://doi.org/10.3892/ijo.2012.1623
Copy and paste a formatted citation
x
Spandidos Publications style
Larsen MS, Yde CW, Christensen IJ and Lykkesfeldt AE: Carboplatin treatment of antiestrogen-resistant breast cancer cells. Int J Oncol 41: 1863-1870, 2012.
APA
Larsen, M.S., Yde, C.W., Christensen, I.J., & Lykkesfeldt, A.E. (2012). Carboplatin treatment of antiestrogen-resistant breast cancer cells. International Journal of Oncology, 41, 1863-1870. https://doi.org/10.3892/ijo.2012.1623
MLA
Larsen, M. S., Yde, C. W., Christensen, I. J., Lykkesfeldt, A. E."Carboplatin treatment of antiestrogen-resistant breast cancer cells". International Journal of Oncology 41.5 (2012): 1863-1870.
Chicago
Larsen, M. S., Yde, C. W., Christensen, I. J., Lykkesfeldt, A. E."Carboplatin treatment of antiestrogen-resistant breast cancer cells". International Journal of Oncology 41, no. 5 (2012): 1863-1870. https://doi.org/10.3892/ijo.2012.1623
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