Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
December 2012 Volume 41 Issue 6

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December 2012 Volume 41 Issue 6

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Differential DNA copy number aberrations in the progression of cervical lesions to invasive cervical carcinoma

  • Authors:
    • Eun Kyeong Oh
    • Yong-Wan Kim
    • In-Wook Kim
    • Hai-Bo Liu
    • Keun-Ho Lee
    • Heung Jae Chun
    • Dong Choon Park
    • Eun-Jee Oh
    • Ah Won Lee
    • Su Mi Bae
    • Woong Shick Ahn
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, The Catholic University of Korea, Seocho-ku, Seoul 137-040, Republic of Korea, Catholic Research Institutes of Medical Science, The Catholic University of Korea, Seocho-ku, Seoul 137-040, Republic of Korea, Institute of Cell and Tissue Engineering, The Catholic University of Korea, Seocho-ku, Seoul 137-040, Republic of Korea, Department of Pathology, College of Medicine, The Catholic University of Korea, Seocho-ku, Seoul 137-040, Republic of Korea
  • Pages: 2038-2046
    |
    Published online on: September 27, 2012
       https://doi.org/10.3892/ijo.2012.1644
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Host genomic alterations in addition to human papillomavirus (HPV) are needed for cervical precursor lesions to progress to invasive cancer because only a small percentage of women infected by the virus develop disease. However, the genomic alterations during the progression of cervical lesions have not been systematically examined. The aim of this study was to identify differential genomic alterations among cervical intraepithelial neoplasia CIN1, CIN2, CIN3 and cervical squamous cell carcinoma (SCC). Genomic alterations were examined for 15 cases each of CIN1, CIN2, CIN3 and SCC by array-based comparative genomic hybridization (array CGH). The chromosomal regions showing significant differential in DNA copy number aberrations (DCNAs) among CIN1, CIN2, CIN3 and SCC were successfully identified by resampling-based t-test. The chromosomal regions of 5q35.3 and 2q14.3 showed significant DCNAs between CIN1 and CIN2, and between CIN2 and CIN3, respectively, while a significant difference in DCNAs between CIN3 and SCC was observed at 1q24.3, 3p14.1, 3p14.2, 5q13.2, 7p15.3, 7q22.1 and 13q32.3. In addition, the status of DCNAs in 1q43, 2p11.2, 6p11.2, 7p21.1, 7p14.3, 10q24.1, 13q22.3, 13q34 and 16p13.3 was conserved throughout the progression of CIN to SCC. The presence of differential and common DCNAs among CIN1, CIN2, CIN3 and SCC supports that the CIN progression may include continual clonal selection and evolution. This approach also identified 34 probe sets consistently overexpressed when amplified, suggesting an unbiased identification of candidate genes in SCC during cervical cancer progression.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1. 

Green J, Berrington de Gonzalez A, Sweetland S, et al: Risk factors for adenocarcinoma and squamous cell carcinoma of the cervix in women aged 20–44 years: the UK National Case-Control Study of Cervical Cancer. Br J Cancer. 89:2078–2086. 2003.

2. 

Pisani P, Bray F and Parkin DM: Estimates of the world-wide prevalence of cancer for 25 sites in the adult population. Int J Cancer. 97:72–81. 2002. View Article : Google Scholar : PubMed/NCBI

3. 

Termini L, Maciag PC, Soares FA, et al: Analysis of human kallikrein 7 expression as a potential biomarker in cervical neoplasia. Int J Cancer. 127:485–490. 2010.PubMed/NCBI

4. 

Lockwood WW, Coe BP, Williams AC, MacAulay C and Lam WL: Whole genome tiling path array CGH analysis of segmental copy number alterations in cervical cancer cell lines. Int J Cancer. 120:436–443. 2007. View Article : Google Scholar : PubMed/NCBI

5. 

Heselmeyer K, Schrock E, du Manoir S, et al: Gain of chromosome 3q defines the transition from severe dysplasia to invasive carcinoma of the uterine cervix. Proc Natl Acad Sci USA. 93:479–484. 1996. View Article : Google Scholar : PubMed/NCBI

6. 

Rapp L and Chen JJ: The papillomavirus E6 proteins. Biochim Biophys Acta. 1378:F1–19. 1998.PubMed/NCBI

7. 

Hillemanns P, Wang X, Staehle S, Michels W and Dannecker C: Evaluation of different treatment modalities for vulvar intraepithelial neoplasia (VIN): CO(2) laser vaporization, photodynamic therapy, excision and vulvectomy. Gynecol Oncol. 100:271–275. 2006. View Article : Google Scholar

8. 

Tranbaloc P: [Natural history of precursor lesions of cervical cancer]. Gynecol Obstet Fertil. 36:650–655. 2008.(In French).

9. 

Wilting SM, Steenbergen RD, Tijssen M, et al: Chromosomal signatures of a subset of high-grade premalignant cervical lesions closely resemble invasive carcinomas. Cancer Res. 69:647–655. 2009. View Article : Google Scholar : PubMed/NCBI

10. 

Ueda Y, Enomoto T, Miyatake T, et al: Monoclonal expansion with integration of high-risk type human papillomaviruses is an initial step for cervical carcinogenesis: association of clonal status and human papillomavirus infection with clinical outcome in cervical intraepithelial neoplasia. Lab Invest. 83:1517–1527. 2003. View Article : Google Scholar

11. 

van Zeeburg HJ, Snijders PJ, Pals G, et al: Generation and molecular characterization of head and neck squamous cell lines of fanconi anemia patients. Cancer Res. 65:1271–1276. 2005.PubMed/NCBI

12. 

van der Laan MJ, Dudoit S and Pollard KS: Augmentation procedures for control of the generalized family-wise error rate and tail probabilities for the proportion of false positives. Stat Appl Genet Mol Biol. 3:Jun 15–2004.(Epub ahead of print).

13. 

Fitzpatrick MA, Funk MC, Gius D, et al: Identification of chromosomal alterations important in the development of cervical intraepithelial neoplasia and invasive carcinoma using alignment of DNA microarray data. Gynecol Oncol. 103:458–462. 2006. View Article : Google Scholar

14. 

Zhai Y, Kuick R, Nan B, et al: Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion. Cancer Res. 67:10163–10172. 2007. View Article : Google Scholar : PubMed/NCBI

15. 

Alazawi W, Pett M, Strauss S, et al: Genomic imbalances in 70 snap-frozen cervical squamous intraepithelial lesions: associations with lesion grade, state of the HPV16 E2 gene and clinical outcome. Br J Cancer. 91:2063–2070. 2004. View Article : Google Scholar

16. 

Kang JU, Koo SH, Kwon KC, Park JW and Kim JM: Identification of novel candidate target genes, including EPHB3, MASP1 and SST at 3q26.2–q29 in squamous cell carcinoma of the lung. BMC Cancer. 9:2372009.PubMed/NCBI

17. 

Milde T, Oehme I, Korshunov A, et al: HDAC5 and HDAC9 in medulloblastoma: novel markers for risk stratification and role in tumor cell growth. Clin Cancer Res. 16:3240–3252. 2010. View Article : Google Scholar : PubMed/NCBI

18. 

Yang Q, Jie Z, Cao H, et al: Low-level expression of let-7a in gastric cancer and its involvement in tumorigenesis by targeting RAB40C. Carcinogenesis. 32:713–722. 2011. View Article : Google Scholar : PubMed/NCBI

19. 

Matsuura M, Onimaru M, Yonemitsu Y, et al: Autocrine loop between vascular endothelial growth factor (VEGF)-C and VEGF receptor-3 positively regulates tumor-associated lymphangiogenesis in oral squamoid cancer cells. Am J Pathol. 175:1709–1721. 2009. View Article : Google Scholar

20. 

Habuchi H, Miyake G, Nogami K, et al: Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate 6-O-sulphotransferase-2 having different expression patterns and properties. Biochem J. 371:131–142. 2003. View Article : Google Scholar

21. 

Narayan G, Pulido HA, Koul S, et al: Genetic analysis identifies putative tumor suppressor sites at 2q35–q36.1 and 2q36.3–q37.1 involved in cervical cancer progression. Oncogene. 22:3489–3499. 2003.PubMed/NCBI

22. 

Rao PH, Arias-Pulido H, Lu XY, et al: Chromosomal amplifications, 3q gain and deletions of 2q33–q37 are the frequent genetic changes in cervical carcinoma. BMC Cancer. 4:52004.

23. 

Zimmerman ES, Chen J, Andersen JL, et al: Human immuno-deficiency virus type 1 Vpr-mediated G2 arrest requires Rad17 and Hus1 and induces nuclear BRCA1 and gamma-H2AX focus formation. Mol Cell Biol. 24:9286–9294. 2004. View Article : Google Scholar : PubMed/NCBI

24. 

Liang M, Ueno M, Oomizu S, et al: Galectin-9 expression links to malignant potential of cervical squamous cell carcinoma. J Cancer Res Clin Oncol. 134:899–907. 2008. View Article : Google Scholar : PubMed/NCBI

25. 

Tan GC, Sharifah NA, Shiran MS, Salwati S, Hatta AZ and Paul-Ng HO: Utility of Ki-67 and p53 in distinguishing cervical intraepithelial neoplasia 3 from squamous cell carcinoma of the cervix. Asian Pac J Cancer Prev. 9:781–784. 2008.PubMed/NCBI

26. 

Tonk VS, Wilson GN, Yatsenko SA, et al: Molecular cytogenetic characterization of a familial der(1)del(1)(p36.33)dup(1) (p36.33p36.22) with variable phenotype. Am J Med Genet A. 139A:136–140. 2005. View Article : Google Scholar : PubMed/NCBI

27. 

Chen M, Ye Y, Yang H, et al: Genome-wide profiling of chromosomal alterations in renal cell carcinoma using high-density single nucleotide polymorphism arrays. Int J Cancer. 125:2342–2348. 2009. View Article : Google Scholar : PubMed/NCBI

28. 

Heilstedt HA, Ballif BC, Howard LA, Kashork CD and Shaffer LG: Population data suggest that deletions of 1p36 are a relatively common chromosome abnormality. Clin Genet. 64:310–316. 2003. View Article : Google Scholar : PubMed/NCBI

29. 

Garnis C, Coe BP, Ishkanian A, Zhang L, Rosin MP and Lam WL: Novel regions of amplification on 8q distinct from the MYC locus and frequently altered in oral dysplasia and cancer. Genes Chromosomes Cancer. 39:93–98. 2004. View Article : Google Scholar : PubMed/NCBI

30. 

Schlaepfer DD and Mitra SK: Multiple connections link FAK to cell motility and invasion. Curr Opin Genet Dev. 14:92–101. 2004. View Article : Google Scholar : PubMed/NCBI

31. 

Luo M, Fan H, Nagy T, et al: Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells. Cancer Res. 69:466–474. 2009. View Article : Google Scholar

32. 

Ohkuni T, Kojima T, Ogasawara N, et al: Expression and localization of tricellulin in human nasal epithelial cells in vivo and in vitro. Med Mol Morphol. 42:204–211. 2009. View Article : Google Scholar : PubMed/NCBI

33. 

Benedicto I, Molina-Jimenez F, Bartosch B, et al: The tight junction-associated protein occludin is required for a postbinding step in hepatitis C virus entry and infection. J Virol. 83:8012–8020. 2009. View Article : Google Scholar : PubMed/NCBI

34. 

Li W, Wang W, Si M, et al: The physical state of HPV16 infection and its clinical significance in cancer precursor lesion and cervical carcinoma. J Cancer Res Clin Oncol. 134:1355–1361. 2008. View Article : Google Scholar : PubMed/NCBI

35. 

Singh RK, Dasgupta S, Bhattacharya N, et al: Deletion in chromosome 11 and Bcl-1/Cyclin D1 alterations are independently associated with the development of uterine cervical carcinoma. J Cancer Res Clin Oncol. 131:395–406. 2005. View Article : Google Scholar : PubMed/NCBI

36. 

Gallego MI, Schoenmakers EF, van de Ven WJ and Lazo PA: Complex genomic rearrangement within the 12q15 multiple aberration region induced by integrated human papillomavirus 18 in a cervical carcinoma cell line. Mol Carcinog. 19:114–121. 1997. View Article : Google Scholar

37. 

Lazo PA: The molecular genetics of cervical carcinoma. Br J Cancer. 80:2008–2018. 1999. View Article : Google Scholar : PubMed/NCBI

38. 

Reuter S, Bartelmann M, Vogt M, et al: APM-1, a novel human gene, identified by aberrant co-transcription with papillomavirus oncogenes in a cervical carcinoma cell line, encodes a BTB/POZ-zinc finger protein with growth inhibitory activity. EMBO J. 17:215–222. 1998. View Article : Google Scholar

39. 

Thorland EC, Myers SL, Gostout BS and Smith DI: Common fragile sites are preferential targets for HPV16 integrations in cervical tumors. Oncogene. 22:1225–1237. 2003. View Article : Google Scholar : PubMed/NCBI

40. 

Pollack JR, Sorlie T, Perou CM, et al: Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors. Proc Natl Acad Sci USA. 99:12963–12968. 2002. View Article : Google Scholar : PubMed/NCBI

41. 

Hyman E, Kauraniemi P, Hautaniemi S, et al: Impact of DNA amplification on gene expression patterns in breast cancer. Cancer Res. 62:6240–6245. 2002.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Oh EK, Kim Y, Kim I, Liu H, Lee K, Chun HJ, Park DC, Oh E, Lee AW, Bae SM, Bae SM, et al: Differential DNA copy number aberrations in the progression of cervical lesions to invasive cervical carcinoma. Int J Oncol 41: 2038-2046, 2012.
APA
Oh, E.K., Kim, Y., Kim, I., Liu, H., Lee, K., Chun, H.J. ... Ahn, W.S. (2012). Differential DNA copy number aberrations in the progression of cervical lesions to invasive cervical carcinoma. International Journal of Oncology, 41, 2038-2046. https://doi.org/10.3892/ijo.2012.1644
MLA
Oh, E. K., Kim, Y., Kim, I., Liu, H., Lee, K., Chun, H. J., Park, D. C., Oh, E., Lee, A. W., Bae, S. M., Ahn, W. S."Differential DNA copy number aberrations in the progression of cervical lesions to invasive cervical carcinoma". International Journal of Oncology 41.6 (2012): 2038-2046.
Chicago
Oh, E. K., Kim, Y., Kim, I., Liu, H., Lee, K., Chun, H. J., Park, D. C., Oh, E., Lee, A. W., Bae, S. M., Ahn, W. S."Differential DNA copy number aberrations in the progression of cervical lesions to invasive cervical carcinoma". International Journal of Oncology 41, no. 6 (2012): 2038-2046. https://doi.org/10.3892/ijo.2012.1644
Copy and paste a formatted citation
x
Spandidos Publications style
Oh EK, Kim Y, Kim I, Liu H, Lee K, Chun HJ, Park DC, Oh E, Lee AW, Bae SM, Bae SM, et al: Differential DNA copy number aberrations in the progression of cervical lesions to invasive cervical carcinoma. Int J Oncol 41: 2038-2046, 2012.
APA
Oh, E.K., Kim, Y., Kim, I., Liu, H., Lee, K., Chun, H.J. ... Ahn, W.S. (2012). Differential DNA copy number aberrations in the progression of cervical lesions to invasive cervical carcinoma. International Journal of Oncology, 41, 2038-2046. https://doi.org/10.3892/ijo.2012.1644
MLA
Oh, E. K., Kim, Y., Kim, I., Liu, H., Lee, K., Chun, H. J., Park, D. C., Oh, E., Lee, A. W., Bae, S. M., Ahn, W. S."Differential DNA copy number aberrations in the progression of cervical lesions to invasive cervical carcinoma". International Journal of Oncology 41.6 (2012): 2038-2046.
Chicago
Oh, E. K., Kim, Y., Kim, I., Liu, H., Lee, K., Chun, H. J., Park, D. C., Oh, E., Lee, A. W., Bae, S. M., Ahn, W. S."Differential DNA copy number aberrations in the progression of cervical lesions to invasive cervical carcinoma". International Journal of Oncology 41, no. 6 (2012): 2038-2046. https://doi.org/10.3892/ijo.2012.1644
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team