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Article

Pathway analysis of cancer-associated microRNA targets

  • Authors:
    • Hao Yang
    • Haiyang Zhang
    • Lin Zhu
    • Jin Wang
    • Chenyu Zhang
    • Donghai Li
  • View Affiliations / Copyright

    Affiliations: Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, P.R. China, Institute of Discovery Biology, Jiangsu Simcere Pharmaceutical R__AMB__D Co. Ltd, Nanjing 210042, P.R. China
  • Pages: 2213-2226
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    Published online on: October 11, 2012
       https://doi.org/10.3892/ijo.2012.1658
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Abstract

Carcinogenesis is a multi-step process, which includes oncogene activation, mutation silencing of tumor suppressor genes, impairment of chromosomes or epigenetic changes such as CpG island methylation through various cellular pathways, involving a series of somatic genetic alterations. Furthermore, miRNAs present a mechanism by which genes with diverse functions on multiple pathways can be simultaneously regulated at the post-transcriptional level. However, little is known about the cancer-related pathways through which cancer-associated miRNAs (CA-miRNAs) regulate these processes representing either positive or negative functions in carcinogenesis. This study investigated eleven miRNAs previously identified as cancer-related regulators. Using function and pathway analysis of their targeted genes, the relevance of miRNA regulation in the induction of cancer can be observed. The results showed that CA-miRNAs may function in the post-transcriptional level mainly through manipulating the expression of transcription factors and protein kinases, and target genes for the CA-miRNAs were most prominently predicted to function in the regulation of transcription. Our analysis also highlighted the potential of these CA-miRNAs to regulate the cell differentiation, proliferation, endocytosis and migration signaling logically required to cause a cancer cell mainly through five canonical pathways. Combined with previous cancer studies, the analysis of the relevance between functions of CA-miRNAs and cancer-related pathways exploring different internal carcinogenesis stimuli also revealed the potential of the top five pathways to regulate core carcinogenesis processes. These findings should form a useful knowledge base for potential future development of novel therapeutic treatments.
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Copy and paste a formatted citation
Spandidos Publications style
Yang H, Zhang H, Zhu L, Wang J, Zhang C and Li D: Pathway analysis of cancer-associated microRNA targets. Int J Oncol 41: 2213-2226, 2012.
APA
Yang, H., Zhang, H., Zhu, L., Wang, J., Zhang, C., & Li, D. (2012). Pathway analysis of cancer-associated microRNA targets. International Journal of Oncology, 41, 2213-2226. https://doi.org/10.3892/ijo.2012.1658
MLA
Yang, H., Zhang, H., Zhu, L., Wang, J., Zhang, C., Li, D."Pathway analysis of cancer-associated microRNA targets". International Journal of Oncology 41.6 (2012): 2213-2226.
Chicago
Yang, H., Zhang, H., Zhu, L., Wang, J., Zhang, C., Li, D."Pathway analysis of cancer-associated microRNA targets". International Journal of Oncology 41, no. 6 (2012): 2213-2226. https://doi.org/10.3892/ijo.2012.1658
Copy and paste a formatted citation
x
Spandidos Publications style
Yang H, Zhang H, Zhu L, Wang J, Zhang C and Li D: Pathway analysis of cancer-associated microRNA targets. Int J Oncol 41: 2213-2226, 2012.
APA
Yang, H., Zhang, H., Zhu, L., Wang, J., Zhang, C., & Li, D. (2012). Pathway analysis of cancer-associated microRNA targets. International Journal of Oncology, 41, 2213-2226. https://doi.org/10.3892/ijo.2012.1658
MLA
Yang, H., Zhang, H., Zhu, L., Wang, J., Zhang, C., Li, D."Pathway analysis of cancer-associated microRNA targets". International Journal of Oncology 41.6 (2012): 2213-2226.
Chicago
Yang, H., Zhang, H., Zhu, L., Wang, J., Zhang, C., Li, D."Pathway analysis of cancer-associated microRNA targets". International Journal of Oncology 41, no. 6 (2012): 2213-2226. https://doi.org/10.3892/ijo.2012.1658
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