Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
December 2012 Volume 41 Issue 6

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December 2012 Volume 41 Issue 6

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Serum protein levels following surgery in breast cancer patients: A protein microarray approach

  • Authors:
    • Luis G. Perez-Rivas
    • Jose M. Jerez
    • Cristina E. Fernandez-De Sousa
    • Vanessa de Luque
    • Cristina Quero
    • Bella Pajares
    • Leonardo  Franco
    • Alfonso Sanchez-Muñoz
    • Nuria Ribelles
    • Emilio Alba
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Hospital Universitario Virgen de la Victoria, Campus de Teatinos s/n, 29010 Malaga, Spain, Department of Languages and Computer Science, University of Malaga, Campus de Teatinos s/n, 29071 Malaga, Spain
  • Pages: 2200-2206
    |
    Published online on: October 16, 2012
       https://doi.org/10.3892/ijo.2012.1667
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Surgery is the primary treatment for non-metastatic breast cancer. However, the risk of early recurrence remains after surgical removal of the primary tumor. Recurrence is suggested to result from hidden micrometastatic foci, which are triggered to escape from dormancy by surgical resection of the primary tumor. In this study, we focused on the differential impact of breast surgery on the serum profiles of early breast cancer patients and healthy women. Serum samples from invasive breast cancer patients, in situ carcinoma breast cancer patients and healthy women were analyzed using reverse phase protein array technology. Samples were collected prior to breast surgery and 24 h following breast surgery. Both the expression level and the velocity of 42 serum proteins were quantified and compared among groups. We found that surgery increased the concentration of several proteins (CSF1, THSB2, IL6, IL7, IL16, FasL and VEGF-B) in the overall population. Compared with healthy women and patients with non-invasive tumors, invasive tumor patients exhibited higher preoperative levels of several serum proteins, such as αFP, IFNβ1, VEGF-A, IL18, E-cadherin or CD31, and lower postoperative levels of TNFα and IL5. Similarly, we detected significant surgery-induced changes in the velocity of VEGF-A and IL16 accumulation in samples derived from invasive breast cancer patients. In conclusion, breast surgery induced distinct changes in the concentrations and dynamics of serum proteins in invasive breast cancer patients compared with healthy women and non-invasive tumor patients.
View Figures

Figure 1

Figure 2

View References

1. 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar

2. 

Perou CM, Sørlie T, Eisen MB, van De Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, et al: Molecular portraits of human breast tumours. Nature. 406:747–752. 2000. View Article : Google Scholar : PubMed/NCBI

3. 

Anderson WF and Matsuno R: Breast cancer heterogeneity: a mixture of at least two main types? J Natl Cancer Inst. 98:948–951. 2006. View Article : Google Scholar : PubMed/NCBI

4. 

Børresen-Dale AL, Sørlie T and Kristensen VN: On the molecular biology of breast cancer. Mol Oncol. 4:171–173. 2010.

5. 

Sørlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van De Rijn M, Jeffrey SS, et al: Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA. 98:10869–10874. 2001.PubMed/NCBI

6. 

Baum M, Demicheli R, Hrushesky W and Retsky MW: Does surgery unfavourably perturb the ‘natural history’ of early breast cancer by accelerating the appearance of distant metastases? Eur J Cancer. 41:508–515. 2005.PubMed/NCBI

7. 

Demicheli R, Retsky MW, Hrushesky WJM, Baum M and Gukas ID: The effects of surgery on tumor growth: a century of investigations. Ann Oncol. 19:1821–1828. 2008. View Article : Google Scholar : PubMed/NCBI

8. 

Fehm T, Mueller V, Marches R, Klein G, Gueckel B, Neubauer H, Solomayer E and Becker S: Tumor cell dormancy: implications for the biology and treatment of breast cancer. Acta Pathol Microbiol Immunol Scand. 116:742–753. 2008. View Article : Google Scholar : PubMed/NCBI

9. 

Tseng WW, Fadaki N and Leong SP: Metastatic tumor dormancy in cutaneous melanoma: Does surgery induce escape? Cancers. 3:730–746. 2011. View Article : Google Scholar : PubMed/NCBI

10. 

Retsky MW, Demicheli R, Hrushesky W, Baum M and Gukas I: Surgery triggers outgrowth of latent distant disease in breast cancer: An inconvenient truth? Cancers. 2:305–337. 2010. View Article : Google Scholar : PubMed/NCBI

11. 

Uhr JW and Pantel K: Controversies in clinical cancer dormancy. Proc Natl Acad Sci USA. 108:1–5. 2011.

12. 

Demicheli R, Retsky MW, Hrushesky WJM and Baum M: Tumor dormancy and surgery-driven interruption of dormancy in breast cancer: learning from failures. Nat Clin Pract Oncol. 4:699–710. 2007. View Article : Google Scholar : PubMed/NCBI

13. 

Aguirre-Ghiso JA: Models, mechanisms and clinical evidence for cancer dormancy. Nat Rev Cancer. 7:834–846. 2007. View Article : Google Scholar : PubMed/NCBI

14. 

Coffey JC, Wang JH, Smith MJF, Bouchier-Hayes D, Cotter TG and Redmond HP: Excisional surgery for cancer cure: therapy at a cost. Lancet Oncol. 4:760–768. 2003. View Article : Google Scholar : PubMed/NCBI

15. 

Spurrier B, Honkanen P, Holway A, Kumamoto K, Terashima M, Takenoshita S, Wakabayashi G, Austin J and Nishizuka S: Protein and lysate array technologies in cancer research. Biotechnol Adv. 26:361–369. 2008. View Article : Google Scholar : PubMed/NCBI

16. 

Mueller C, La Liotta and Espina V: Reverse phase protein microarrays advance to use in clinical trials. Mol Oncol. 4:1–21. 2010. View Article : Google Scholar : PubMed/NCBI

17. 

Sheehan KM, Calvert VS, Kay EW, Lu Y, Fishman D, Espina V, Aquino J, Speer R, Araujo R, Mills GB, et al: Use of reverse phase protein microarrays and reference standard development for molecular network analysis of metastatic ovarian carcinoma. Mol Cell Proteomics. 4:346–355. 2005. View Article : Google Scholar

18. 

Tibes R, Qiu Y, Lu Y, Hennessy B, Andreeff M, Mills GB and Kornblau SM: Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells. Mol Cancer Ther. 5:2512–2521. 2006. View Article : Google Scholar : PubMed/NCBI

19. 

Brennan DJ, O’Connor DP, Rexhepaj E, Ponten F and Gallagher WM: Antibody-based proteomics: fast-tracking molecular diagnostics in oncology. Nat Rev Cancer. 10:605–617. 2010. View Article : Google Scholar : PubMed/NCBI

20. 

Grote T, Siwak DR, Fritsche HA, Joy C, Mills GB, Simeone D, Whitcomb DC and Logsdon CD: Validation of reverse phase protein array for practical screening of potential biomarkers in serum and plasma: accurate detection of CA19-9 levels in pancreatic cancer. Proteomics. 8:3051–3060. 2008. View Article : Google Scholar : PubMed/NCBI

21. 

Holdaway IM, Lethaby AE, Mason BH, Singh V, Harman JE, MacCormick M and Civil ID: Effect of breast surgery on serum levels of insulin-like growth factors (IGF-I, IGF-II, and IGF binding protein-3) in women with benign and malignant breast lesions. Ann Surg Oncol. 8:25–31. 2001. View Article : Google Scholar : PubMed/NCBI

22. 

Smyth GK: Limma: linear models for microarray data. Bioinformatics and Computational Biology Solutions using R and Bioconductor. Gentleman R, Carey V, Dudoit S, Irizarry R and Huber W: Springer; New York, NY: pp. 397–420. 2005, View Article : Google Scholar

23. 

Yang YH and Thorne NP: Normalization for two-color cDNA microarray data. Institute of Mathematical Statistics; 2003

24. 

Smyth GK: Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Gen Mol Biol. 3:Article3, Feb 12, 2004 (Epub ahead of print).

25. 

Benjamini Y and Hochberg Y: Controlling the false discovery rate: A practical and powerful approach to multiple testing. J Roy Stat Soc Ser B (Stat Method). 57:289–300. 1995.

26. 

Carlsson A, Wingren C, Kristensson M, Rose C, Fernö M, Olsson H, Jernström H, Ek S, Gustavsson E, Ingvar C, et al: Molecular serum portraits in patients with primary breast cancer predict the development of distant metastases. Proc Natl Acad Sci USA. 108:14252–14257. 2011. View Article : Google Scholar : PubMed/NCBI

27. 

Gurtner GC, Werner S, Barrandon Y and Longaker MT: Wound repair and regeneration. Nature. 453:314–321. 2008. View Article : Google Scholar : PubMed/NCBI

28. 

Hamilton JA: Colony-stimulating factors in inflammation and autoimmunity. Nat Rev Immunol. 8:533–544. 2008. View Article : Google Scholar : PubMed/NCBI

29. 

Lin Z-Q, Kondo T, Ishida Y, Takayasu T and Mukaida N: Essential involvement of IL-6 in the skin wound-healing process as evidenced by delayed wound healing in IL-6-deficient mice. J Leukoc Biol. 73:713–721. 2003. View Article : Google Scholar : PubMed/NCBI

30. 

Oshika Y, Masuda K, Tokunaga T, Hatanaka H, Kamiya T, Abe Y, Ozeki Y, Kijima H, Yamazaki H, Tamaoki N, et al: Thrombospondin 2 gene expression is correlated with decreased vascularity in non-small cell lung cancer. Clin Cancer Res. 4:1785–1788. 1998.PubMed/NCBI

31. 

Tokunaga T, Nakamura M, Oshika Y, Abe Y, Ozeki Y, Fukushima Y, Hatanaka H, Sadahiro S, Kijima H, Tsuchida T, et al: Thrombospondin 2 expression is correlated with inhibition of angiogenesis and metastasis of colon cancer. Br J Cancer. 79:354–359. 1999. View Article : Google Scholar : PubMed/NCBI

32. 

Maclauchlan S, Skokos EA, Agah A, Zeng J, Tian W, Davidson JM, Bornstein P and Kyriakides TR: Enhanced angiogenesis and reduced contraction in thrombospondin-2-null wounds is associated with increased levels of matrix metalloproteinases-2 and -9, and soluble VEGF. J Histochem Cytochem. 57:301–313. 2009. View Article : Google Scholar : PubMed/NCBI

33. 

Kyriakides TR, Tam JW and Bornstein P: Accelerated wound healing in mice with a disruption of the thrombospondin 2 gene. J Invest Dermatol. 113:782–787. 1999. View Article : Google Scholar : PubMed/NCBI

34. 

Jameson J and Havran WL: Skin gammadelta T-cell functions in homeostasis and wound healing. Immunol Rev. 215:114–122. 2007. View Article : Google Scholar : PubMed/NCBI

35. 

Al-Rawi MAA, Watkins G, Mansel RE and Jiang WG: The effects of interleukin-7 on the lymphangiogenic properties of human endothelial cells. Int J Oncol. 27:721–730. 2005.PubMed/NCBI

36. 

Cruikshank W and Little F: lnterleukin-16: the ins and outs of regulating T-cell activation. Crit Rev Immunol. 28:467–483. 2008. View Article : Google Scholar : PubMed/NCBI

37. 

Stabile E, Kinnaird T, la Sala A, Hanson SK, Watkins C, Campia U, Shou M, Zbinden S, Fuchs S, Kornfeld H, et al: CD8+ T lymphocytes regulate the arteriogenic response to ischemia by infiltrating the site of collateral vessel development and recruiting CD4+ mononuclear cells through the expression of interleukin-16. Circulation. 113:118–124. 2006.

38. 

Al-Rawi MAA, Rmali K, Watkins G, Mansel RE and Jiang WG: Aberrant expression of interleukin-7 (IL-7) and its signalling complex in human breast cancer. Eur J Cancer. 40:494–502. 2004. View Article : Google Scholar : PubMed/NCBI

39. 

Germano G, Allavena P and Mantovani A: Cytokines as a key component of cancer-related inflammation. Cytokine. 43:374–379. 2008. View Article : Google Scholar : PubMed/NCBI

40. 

Studebaker AW, Storci G, Werbeck JL, Sansone P, Sasser AK, Tavolari S, Huang T, Chan MWY, Marini FC, Rosol TJ, et al: Fibroblasts isolated from common sites of breast cancer metastasis enhance cancer cell growth rates and invasiveness in an interleukin-6-dependent manner. Cancer Res. 68:9087–9095. 2008. View Article : Google Scholar

41. 

Hanahan D and Weinberg RA: The hallmarks of cancer. Cell. 100:57–70. 2000. View Article : Google Scholar

42. 

Carlsson A, Wingren C, Ingvarsson J, Ellmark P, Borrebaeck CAK, Baldertorp B, Fernö M and Olsson H: Serum proteome profiling of metastatic breast cancer using recombinant antibody microarrays. Eur J Cancer. 44:472–480. 2008. View Article : Google Scholar : PubMed/NCBI

43. 

Gast M-CW, Zapatka M, van Tinteren H, Bontenbal M, Span PN, Tjan-Heijnen VCG, Knol JC, Jimenez CR, Schellens JHM and Beijnen JH: Postoperative serum proteomic profiles may predict recurrence-free survival in high-risk primary breast cancer. J Cancer Res Clin Oncol. 137:1773–1783. 2011. View Article : Google Scholar : PubMed/NCBI

44. 

Pietrowska M, Polanska J, Marczak L, Behrendt K, Nowicka E, Stobiecki M, Polanski A, Tarnawski R and Widlak P: Mass spectrometry-based analysis of therapy-related changes in serum proteome patterns of patients with early-stage breast cancer. J Transl Med. 8:662010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Perez-Rivas LG, Jerez JM, Fernandez-De Sousa CE, de Luque V, Quero C, Pajares B, Franco L, Sanchez-Muñoz A, Ribelles N, Alba E, Alba E, et al: Serum protein levels following surgery in breast cancer patients: A protein microarray approach. Int J Oncol 41: 2200-2206, 2012.
APA
Perez-Rivas, L.G., Jerez, J.M., Fernandez-De Sousa, C.E., de Luque, V., Quero, C., Pajares, B. ... Alba, E. (2012). Serum protein levels following surgery in breast cancer patients: A protein microarray approach. International Journal of Oncology, 41, 2200-2206. https://doi.org/10.3892/ijo.2012.1667
MLA
Perez-Rivas, L. G., Jerez, J. M., Fernandez-De Sousa, C. E., de Luque, V., Quero, C., Pajares, B., Franco, L., Sanchez-Muñoz, A., Ribelles, N., Alba, E."Serum protein levels following surgery in breast cancer patients: A protein microarray approach". International Journal of Oncology 41.6 (2012): 2200-2206.
Chicago
Perez-Rivas, L. G., Jerez, J. M., Fernandez-De Sousa, C. E., de Luque, V., Quero, C., Pajares, B., Franco, L., Sanchez-Muñoz, A., Ribelles, N., Alba, E."Serum protein levels following surgery in breast cancer patients: A protein microarray approach". International Journal of Oncology 41, no. 6 (2012): 2200-2206. https://doi.org/10.3892/ijo.2012.1667
Copy and paste a formatted citation
x
Spandidos Publications style
Perez-Rivas LG, Jerez JM, Fernandez-De Sousa CE, de Luque V, Quero C, Pajares B, Franco L, Sanchez-Muñoz A, Ribelles N, Alba E, Alba E, et al: Serum protein levels following surgery in breast cancer patients: A protein microarray approach. Int J Oncol 41: 2200-2206, 2012.
APA
Perez-Rivas, L.G., Jerez, J.M., Fernandez-De Sousa, C.E., de Luque, V., Quero, C., Pajares, B. ... Alba, E. (2012). Serum protein levels following surgery in breast cancer patients: A protein microarray approach. International Journal of Oncology, 41, 2200-2206. https://doi.org/10.3892/ijo.2012.1667
MLA
Perez-Rivas, L. G., Jerez, J. M., Fernandez-De Sousa, C. E., de Luque, V., Quero, C., Pajares, B., Franco, L., Sanchez-Muñoz, A., Ribelles, N., Alba, E."Serum protein levels following surgery in breast cancer patients: A protein microarray approach". International Journal of Oncology 41.6 (2012): 2200-2206.
Chicago
Perez-Rivas, L. G., Jerez, J. M., Fernandez-De Sousa, C. E., de Luque, V., Quero, C., Pajares, B., Franco, L., Sanchez-Muñoz, A., Ribelles, N., Alba, E."Serum protein levels following surgery in breast cancer patients: A protein microarray approach". International Journal of Oncology 41, no. 6 (2012): 2200-2206. https://doi.org/10.3892/ijo.2012.1667
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team