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Function and cancer genomics of FAT family genes (Review)

  • Authors:
    • Masaru Katoh
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    Affiliations: Division of Integrative Omics and Bioinformatics, National Cancer Center, Tokyo 104-0045, Japan
    Copyright: © Katoh et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 1913-1918
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    Published online on: October 17, 2012
       https://doi.org/10.3892/ijo.2012.1669
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Abstract

FAT1, FAT2, FAT3 and FAT4 are human homologs of Drosophila Fat, which is involved in tumor suppression and planar cell polarity (PCP). FAT1 and FAT4 undergo the first proteolytic cleavage by Furin and are predicted to undergo the second cleavage by γ‑secretase to release intracellular domain (ICD). Ena/VAPS‑binding to FAT1 induces actin polymerization at lamellipodia and filopodia to promote cell migration, while Scribble‑binding to FAT1 induces phosphorylation and functional inhibition of YAP1 to suppress cell growth. FAT1 is repressed in oral cancer owing to homozygous deletion or epigenetic silencing and is preferentially downregulated in invasive breast cancer. On the other hand, FAT1 is upregulated in leukemia and prognosis of preB‑ALL patients with FAT1 upregulation is poor. FAT4 directly interacts with MPDZ/MUPP1 to recruit membrane‑associated guanylate kinase MPP5/PALS1. FAT4 is involved in the maintenance of PCP and inhibition of cell proliferation. FAT4 mRNA is repressed in breast cancer and lung cancer due to promoter hypermethylation. FAT4 gene is recurrently mutated in several types of human cancers, such as melanoma, pancreatic cancer, gastric cancer and hepatocellular carcinoma. FAT1 and FAT4 suppress tumor growth via activation of Hippo signaling, whereas FAT1 promotes tumor migration via induction of actin polymerization. FAT1 is tumor suppressive or oncogenic in a context‑dependent manner, while FAT4 is tumor suppressive. Copy number aberration, translocation and point mutation of FAT1, FAT2, FAT3, FAT4, FRMD1, FRMD6, NF2, WWC1, WWC2, SAV1, STK3, STK4, MOB1A, MOB1B, LATS1, LATS2, YAP1 and WWTR1/TAZ genes should be comprehensively investigated in various types of human cancers to elucidate the mutation landscape of the FAT‑Hippo signaling cascades. Because YAP1 and WWTR1 are located at the crossroads of adhesion, GPCR, RTK and stem‑cell signaling network, cancer genomics of the FAT signaling cascades could be applied for diagnostics, prognostics and therapeutics in the era of personalized medicine.
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1. 

PJ BryantB HuettnerLI Held JrJ RyerseJ SzidonyaMutations at the fat locus interfere with cell proliferation control and epithelial morphogenesis in DrosophilaDev Biol1295415541988

2. 

DF WoodsPJ BryantThe discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctionsCell664514641991

3. 

D StrandI RaskaBM MechlerThe Drosophila lethal(2) giant larvae tumor suppressor protein is a component of the cytoskeletonJ Cell Biol127134513601994

4. 

RW JusticeO ZilianDF WoodsM NollPJ BryantThe Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferationGenes Dev95345461995

5. 

D BilderN PerrimonLocalization of apical epithelial determinants by the basolateral PDZ protein ScribbleNature403676680200010.1038/3500110810688207

6. 

N TaponKF HarveyDW Bellsalvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell linesCell110467478200210.1016/S0092-8674(02)00824-3

7. 

S PantalacciN TaponP LéopoldThe Salvador partner Hippo promotes apoptosis and cell-cycle exit in DrosophilaNat Cell Biol5921927200310.1038/ncb105114502295

8. 

PJ BryantKL WatsonRW JusticeDF WoodsTumor suppressor genes encoding proteins required for cell interactions and signal transduction in DrosophilaDev Suppl23924919938049479

9. 

IK HariharanD BilderRegulation of imaginal disc growth by tumor-suppressor genes in DrosophilaAnnu Rev Genet40335361200610.1146/annurev.genet.39.073003.10073816872256

10. 

LJ SaucedoBA EdgarFilling out the Hippo pathwayNat Rev Mol Cell Biol8613621200710.1038/nrm222117622252

11. 

BV ReddyKD IrvineThe Fat and Warts signaling pathways: new insights into their regulation, mechanism and conservationDevelopment13528272838200810.1242/dev.02097418697904

12. 

D PanThe hippo signaling pathway in development and cancerDev Cell19491505201010.1016/j.devcel.2010.09.01120951342

13. 

A GenevetN TaponThe Hippo pathway and apico-basal cell polarityBiochem J436213224201110.1042/BJ2011021721568941

14. 

CH YangJD AxelrodMA SimonRegulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eyeCell108675688200210.1016/S0092-8674(02)00658-X11893338

15. 

H StruttD StruttNonautonomous planar polarity patterning in Drosophila: dishevelled-independent functions of frizzledDev Cell3851863200210.1016/S1534-5807(02)00363-512479810

16. 

JD AxelrodProgress and challenges in understanding planar cell polarity signalingSemin Cell Dev Biol20964971200910.1016/j.semcdb.2009.08.00119665570

17. 

A DjianeM MlodzikThe Drosophila GIPC homologue can modulate myosin based processes and planar cell polarity but is not essential for developmentPLoS One5e112282010

18. 

JD AxelrodJR MillerJM ShulmanRT MoonN PerrimonDifferential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathwaysGenes Dev1226102622199810.1101/gad.12.16.26109716412

19. 

M MlodzikPlanar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation?Trends Genet18564571200210.1016/S0168-9525(02)02770-112414186

20. 

M KatohWNT/PCP signaling pathway and human cancer (Review)Oncol Rep1415831588200516273260

21. 

HO IshikawaH TakeuchiRS HaltiwangerKD IrvineFour-jointed is a Golgi kinase that phosphorylates a subset of cadherin domainsScience321401404200810.1126/science.115815918635802

22. 

R SopkoH McNeillThe skinny on Fat: an enormous cadherin that regulates cell adhesion, tissue growth, and planar cell polarityCurr Opin Cell Biol21717723200910.1016/j.ceb.2009.07.00119679459

23. 

C ThomasD StruttThe roles of the cadherins Fat and Dachsous in planar polarity specification in DrosophilaDev Dyn2412739201210.1002/dvdy.2273621919123

24. 

F BosveldI BonnetB GuiraoMechanical control of morphogenesis by Fat/Dachsous/Four-jointed planar cell polarity pathwayScience336724727201210.1126/science.122107122499807

25. 

PA MahoneyU WeberP OnofrechukH BiessmannPJ BryantCS GoodmanThe fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamilyCell678538681991

26. 

T TanoueM TakeichiNew insights into Fat cadherinsJ Cell Sci11823472353200510.1242/jcs.0239815923647

27. 

P HulpiauF van RoyMolecular evolution of the cadherin superfamilyInt J Biochem Cell Biol41349369200910.1016/j.biocel.2008.09.027

28. 

J DunneAM HanbyR PoulsomMolecular cloning and tissue expression of FAT, the human homologue of the Drosophila fat gene that is located on chromosome 4q34-q35 and encodes a putative adhesion moleculeGenomics302072231995

29. 

Q WuT ManiatisLarge exons encoding multiple ectodomains are a characteristic feature of protocadherin genesProc Natl Acad Sci USA9731243129200010.1073/pnas.97.7.312410716726

30. 

JC HöngNV IvanovP HodorIdentification of new human cadherin genes using a combination of protein motif search and gene finding methodsJ Mol Biol337307317200415003449

31. 

Y KatohM KatohComparative integromics on FAT1, FAT2, FAT3 and FAT4Int J Mol Med185235282006

32. 

E SadeqzadehCE de BockXD ZhangDual processing of FAT1 cadherin protein by human melanoma cells generates distinct protein productsJ Biol Chem2862818128191201110.1074/jbc.M111.23441921680732

33. 

T MaggD SchreinerGP SolisEG BadeHW HoferProcessing of the human protocadherin Fat1 and translocation of its cytoplasmic domain to the nucleusExp Cell Res307100108200510.1016/j.yexcr.2005.03.00615922730

34. 

T TanoueM TakeichiMammalian Fat1 cadherin regulates actin dynamics and cell-cell contactJ Cell Biol165517528200410.1083/jcb.20040300615148305

35. 

MJ MoellerA SoofiGS BraunProtocadherin FAT1 binds Ena/VASP proteins and is necessary for actin dynamics and cell polarizationEMBO J2337693779200410.1038/sj.emboj.760038015343270

36. 

D SchreinerK MüllerHW HoferThe intracellular domain of the human protocadherin hFat1 interacts with Homer signalling scaffolding proteinsFEBS Lett58052955300200610.1016/j.febslet.2006.08.07916979624

37. 

K SkouloudakiM PuetzM SimonsScribble participates in Hippo signaling and is required for normal zebrafish pronephros developmentProc Natl Acad Sci USA10685798584200910.1073/pnas.081169110619439659

38. 

R HouL LiuS AneesS HiroyasuNE SibingaThe Fat1 cadherin integrates vascular smooth muscle cell growth and migration signalsJ Cell Biol173417429200610.1083/jcb.20050812116682528

39. 

T IshiuchiK MisakiS YonemuraM TakeichiT TanoueMammalian Fat and Dachsous cadherins regulate apical membrane organization in the embryonic cerebral cortexJ Cell Biol185959967200910.1083/jcb.20081103019506035

40. 

M KatohM KatohIdentification and characterization of human MPP7 gene and mouse Mpp7 gene in silicoInt J Mol Med133333382004

41. 

S SaburiI HesterE FischerLoss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney diseaseNat Genet40101010152008

42. 

C JonesP ChenPlanar cell polarity signaling in vertebratesBioessays29120132200710.1002/bies.2052617226800

43. 

Z KibarKJ VoganN GroulxMJ JusticeDA UnderhillP GrosLtap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tailNat Genet28251255200110.1038/90081

44. 

NJ van HaterenRM DasGM HautbergueAG BoryckiM PlaczekSA WilsonFatJ acts via the Hippo mediator Yap1 to restrict the size of neural progenitor cell poolsDevelopment13818931902201121521736

45. 

K NakayaHD YamagataN AritaIdentification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-arrayOncogene2653005308200710.1038/sj.onc.121033017325662

46. 

K ChosdolA MisraS PuriFrequent loss of heterozygosity and altered expression of the candidate tumor suppressor gene ‘FAT’ in human astrocytic tumorsBMC Cancer95200910.1186/1471-2407-9-519126244

47. 

S LeeS StewartI NagtegaalDifferentially expressed genes regulating the progression of ductal carcinoma in situ to invasive breast cancerCancer Res7245744586201210.1158/0008-5472.CAN-12-063622751464

48. 

CE de BockA ArdjmandTJ MolloyThe Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis-relapse samples of precursor B-cell acute lymphoblastic leukemiaLeukemia26918926201222116550

49. 

J SettakornN KaewpilaGF BurnsAS LeongFAT, E-cadherin, β-catenin, HER 2/neu, Ki67 immuno-expression, and histological grade in intrahepatic cholangiocarcinomaJ Clin Pathol58124912542005

50. 

A RohrbeckJ BorlakCancer genomics identifies regulatory gene networks associated with the transition from dysplasia to advanced lung adenocarcinomas induced by c-Raf-1PLoS One4e7315200910.1371/journal.pone.000731519812696

51. 

C QiYT ZhuL HuYJ ZhuIdentification of Fat4 as a candidate tumor suppressor gene in breast cancersInt J Cancer1247937982009

52. 

TA RauchZ WangX WuKH KernstineAD RiggsGP PfeiferDNA methylation biomarkers for lung cancerTumour Biol33287296201210.1007/s13277-011-0282-222143938

53. 

S JonesX ZhangDW ParsonsCore signaling pathways in human pancreatic cancers revealed by global genomic analysesScience32118011806200810.1126/science.116436818772397

54. 

N AgrawalMJ FrederickCR PickeringExome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1Science33311541157201110.1126/science.120692321798897

55. 

M LiH ZhaoX ZhangInactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinomaNat Genet43828829201110.1038/ng.903

56. 

SI NikolaevD RimoldiC IseliExome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanomaNat Genet44133139201110.1038/ng.1026

57. 

ZJ ZangI CutcutacheSL PoonExome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genesNat Genet44570574201210.1038/ng.224622484628

58. 

M ImajoK MiyatakeA IimuraA MiyamotoE NishidaA molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signallingEMBO J3111091122201222234184

59. 

M KatohM KatohWNT signaling pathway and stem cell signaling networkClin Cancer Res1340424045200710.1158/1078-0432.CCR-06-231617634527

60. 

FX YuB ZhaoN PanupinthuRegulation of the Hippo-YAP pathway by G-Protein-coupled receptor signalingCell150780791201210.1016/j.cell.2012.06.03722863277

61. 

W HuangX LvC LiuThe N-terminal phosphodegron targets TAZ/WWTR1 protein for SCF β-TrCP-dependent degradation in response to phosphatidylinositol 3-kinase inhibitionJ Biol Chem2872624526253201222692215

62. 

M CordenonsiF ZanconatoL AzzolinThe Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cellsCell147759772201110.1016/j.cell.2011.09.04822078877

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Copy and paste a formatted citation
Spandidos Publications style
Katoh M: Function and cancer genomics of FAT family genes (Review) . Int J Oncol 41: 1913-1918, 2012.
APA
Katoh, M. (2012). Function and cancer genomics of FAT family genes (Review) . International Journal of Oncology, 41, 1913-1918. https://doi.org/10.3892/ijo.2012.1669
MLA
Katoh, M."Function and cancer genomics of FAT family genes (Review) ". International Journal of Oncology 41.6 (2012): 1913-1918.
Chicago
Katoh, M."Function and cancer genomics of FAT family genes (Review) ". International Journal of Oncology 41, no. 6 (2012): 1913-1918. https://doi.org/10.3892/ijo.2012.1669
Copy and paste a formatted citation
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Spandidos Publications style
Katoh M: Function and cancer genomics of FAT family genes (Review) . Int J Oncol 41: 1913-1918, 2012.
APA
Katoh, M. (2012). Function and cancer genomics of FAT family genes (Review) . International Journal of Oncology, 41, 1913-1918. https://doi.org/10.3892/ijo.2012.1669
MLA
Katoh, M."Function and cancer genomics of FAT family genes (Review) ". International Journal of Oncology 41.6 (2012): 1913-1918.
Chicago
Katoh, M."Function and cancer genomics of FAT family genes (Review) ". International Journal of Oncology 41, no. 6 (2012): 1913-1918. https://doi.org/10.3892/ijo.2012.1669
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