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Autoantibodies against insulin-like growth factor‑binding protein-2 as a serological biomarker in the diagnosis of lung cancer

  • Authors:
    • Ying Zhang
    • Xia Ying
    • Suxia Han
    • Jing Wang
    • Xia Zhou
    • E Bai
    • Jianying Zhang
    • Qing Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The First Affiliated Hospital of Xi'an Jiao Tong University Medical Center, Xi'an, Shaanxi 710061, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 93-100
    |
    Published online on: November 15, 2012
       https://doi.org/10.3892/ijo.2012.1699
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Abstract

Insulin-like growth factor-binding protein-2 (IGFBP-2) is considered to be a human tumor antigen, and the tumor-specific immunity of IGFBP-2 has been reported in several types of cancer. The purpose of this study was to evaluate whether autoantibodies to IGFBP-2 can be used as diagnostic markers in lung cancer. The results demonstrated that serum anti-IGFBP-2 autoantibody levels were significantly elevated in lung cancer (mean, 1,633.318 ng/ml; median, 1,651.462 ng/ml; range, 342.732-4932.582 ng/ml) compared with benign lung disease (1,210.139, 1,035.900, 547.596‑2,331.167 ng/ml) and normal controls (1,303.369, 1,194.800, 528.200-2140.500 ng/ml). The sensitivity and specificity of anti-IGFBP-2 autoantibodies in diagnosing lung cancer was 73.2 and 60.6%, respectively. When serum IGFBP-2 and anti-IGFBP-2 autoantibody were used together in the diagnosis of lung cancer, it can increase the discriminative power for lung cancer with a sensitivity of 85.7% and a specificity of 57.5%. In conclusion, this study demonstrates that circulating anti-IGFBP-2 autoantibodies can be used as a potential biomarker in diagnosing lung cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Ying X, Han S, Wang J, Zhou X, Bai E, Zhang J and Zhu Q: Autoantibodies against insulin-like growth factor‑binding protein-2 as a serological biomarker in the diagnosis of lung cancer. Int J Oncol 42: 93-100, 2013.
APA
Zhang, Y., Ying, X., Han, S., Wang, J., Zhou, X., Bai, E. ... Zhu, Q. (2013). Autoantibodies against insulin-like growth factor‑binding protein-2 as a serological biomarker in the diagnosis of lung cancer. International Journal of Oncology, 42, 93-100. https://doi.org/10.3892/ijo.2012.1699
MLA
Zhang, Y., Ying, X., Han, S., Wang, J., Zhou, X., Bai, E., Zhang, J., Zhu, Q."Autoantibodies against insulin-like growth factor‑binding protein-2 as a serological biomarker in the diagnosis of lung cancer". International Journal of Oncology 42.1 (2013): 93-100.
Chicago
Zhang, Y., Ying, X., Han, S., Wang, J., Zhou, X., Bai, E., Zhang, J., Zhu, Q."Autoantibodies against insulin-like growth factor‑binding protein-2 as a serological biomarker in the diagnosis of lung cancer". International Journal of Oncology 42, no. 1 (2013): 93-100. https://doi.org/10.3892/ijo.2012.1699
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Ying X, Han S, Wang J, Zhou X, Bai E, Zhang J and Zhu Q: Autoantibodies against insulin-like growth factor‑binding protein-2 as a serological biomarker in the diagnosis of lung cancer. Int J Oncol 42: 93-100, 2013.
APA
Zhang, Y., Ying, X., Han, S., Wang, J., Zhou, X., Bai, E. ... Zhu, Q. (2013). Autoantibodies against insulin-like growth factor‑binding protein-2 as a serological biomarker in the diagnosis of lung cancer. International Journal of Oncology, 42, 93-100. https://doi.org/10.3892/ijo.2012.1699
MLA
Zhang, Y., Ying, X., Han, S., Wang, J., Zhou, X., Bai, E., Zhang, J., Zhu, Q."Autoantibodies against insulin-like growth factor‑binding protein-2 as a serological biomarker in the diagnosis of lung cancer". International Journal of Oncology 42.1 (2013): 93-100.
Chicago
Zhang, Y., Ying, X., Han, S., Wang, J., Zhou, X., Bai, E., Zhang, J., Zhu, Q."Autoantibodies against insulin-like growth factor‑binding protein-2 as a serological biomarker in the diagnosis of lung cancer". International Journal of Oncology 42, no. 1 (2013): 93-100. https://doi.org/10.3892/ijo.2012.1699
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