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International Journal of Oncology
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Article

microRNA-372 maintains oncogene characteristics by targeting TNFAIP1 and affects NFκB signaling in human gastric carcinoma cells

  • Authors:
    • Chang Zhou
    • Xiaofeng Li
    • Xiaoting Zhang
    • Xizhi Liu
    • Zhiwen Tan
    • Celi Yang
    • Jian Zhang
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Protein Chemistry and Developmental Biology of State Education Ministry of China, College of Life Science, Hunan Normal University, Changsha, Hunan 410081, P.R. China
  • Pages: 635-642
    |
    Published online on: December 13, 2012
       https://doi.org/10.3892/ijo.2012.1737
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Abstract

Aberrant microRNA (miRNA) expression has been investigated in gastric cancer, which is one of the most common malignancies. However, the roles of miRNAs in gastric cancer remain largely unknown. In the present study, we found that microRNA-372 (miR-372) directly targets tumor necrosis factor, α-induced protein 1 (TNFAIP1), and is involved in the regulation of the NFκB signaling pathway. Furthermore, overexpression of TNFAIP1 induced changes in AGS cells similar to those in AGS cells treated with miR-372-ASO. Collectively, these findings demonstrate an oncogenic role for miR-372 in controlling cell growth and apoptosis through downregulation of TNFAIP1. This novel molecular basis provides new insights into the etiology of gastric cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou C, Li X, Zhang X, Liu X, Tan Z, Yang C and Zhang J: microRNA-372 maintains oncogene characteristics by targeting TNFAIP1 and affects NFκB signaling in human gastric carcinoma cells. Int J Oncol 42: 635-642, 2013.
APA
Zhou, C., Li, X., Zhang, X., Liu, X., Tan, Z., Yang, C., & Zhang, J. (2013). microRNA-372 maintains oncogene characteristics by targeting TNFAIP1 and affects NFκB signaling in human gastric carcinoma cells. International Journal of Oncology, 42, 635-642. https://doi.org/10.3892/ijo.2012.1737
MLA
Zhou, C., Li, X., Zhang, X., Liu, X., Tan, Z., Yang, C., Zhang, J."microRNA-372 maintains oncogene characteristics by targeting TNFAIP1 and affects NFκB signaling in human gastric carcinoma cells". International Journal of Oncology 42.2 (2013): 635-642.
Chicago
Zhou, C., Li, X., Zhang, X., Liu, X., Tan, Z., Yang, C., Zhang, J."microRNA-372 maintains oncogene characteristics by targeting TNFAIP1 and affects NFκB signaling in human gastric carcinoma cells". International Journal of Oncology 42, no. 2 (2013): 635-642. https://doi.org/10.3892/ijo.2012.1737
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou C, Li X, Zhang X, Liu X, Tan Z, Yang C and Zhang J: microRNA-372 maintains oncogene characteristics by targeting TNFAIP1 and affects NFκB signaling in human gastric carcinoma cells. Int J Oncol 42: 635-642, 2013.
APA
Zhou, C., Li, X., Zhang, X., Liu, X., Tan, Z., Yang, C., & Zhang, J. (2013). microRNA-372 maintains oncogene characteristics by targeting TNFAIP1 and affects NFκB signaling in human gastric carcinoma cells. International Journal of Oncology, 42, 635-642. https://doi.org/10.3892/ijo.2012.1737
MLA
Zhou, C., Li, X., Zhang, X., Liu, X., Tan, Z., Yang, C., Zhang, J."microRNA-372 maintains oncogene characteristics by targeting TNFAIP1 and affects NFκB signaling in human gastric carcinoma cells". International Journal of Oncology 42.2 (2013): 635-642.
Chicago
Zhou, C., Li, X., Zhang, X., Liu, X., Tan, Z., Yang, C., Zhang, J."microRNA-372 maintains oncogene characteristics by targeting TNFAIP1 and affects NFκB signaling in human gastric carcinoma cells". International Journal of Oncology 42, no. 2 (2013): 635-642. https://doi.org/10.3892/ijo.2012.1737
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