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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 2013 Volume 42 Issue 3

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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

Highly lymphatic metastatic pancreatic cancer cells possess stem cell-like properties

  • Authors:
    • Guopei Luo
    • Jiang Long
    • Xiaobo Cui
    • Zhiwen Xiao
    • Zuqiang Liu
    • Si Shi
    • Liang Liu
    • Chen Liu
    • Jin Xu
    • Min Li
    • Xianjun Yu
  • View Affiliations / Copyright

    Affiliations: Department of Pancreatic and Hepatobiliary Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University; Pancreatic Cancer Institute, Fudan University, Shanghai 200032, P.R. China, The Vivian L. Smith Department of Neurosurgery, The University of Texas Medical School at Houston, Houston, TX 77030, USA
  • Pages: 979-984
    |
    Published online on: January 18, 2013
       https://doi.org/10.3892/ijo.2013.1780
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Abstract

Cancer stem cells are thought to be the origin of tumor metastasis. However, evidence of cancer stem cells as the source of lymphatic metastasis in pancreatic cancer is not clear. In this study, we examined the stem cell-like properties of the highly lymphatic metastatic pancreatic cancer cells BxPC-3-LN. Compared with the parental BxPC-3 cells, the BxPC-3-LN cells showed stem cell-like properties, including high lymphatic metastasis potential, self-renewal ability and chemoresistance. In addition, the BxPC-3-LN cells also expressed higher levels of sonic hedgehog and migrating cancer stem cell surface markers (CD133 and CXCR4) compared to the parental BxPC-3 cells. The growth of BxPC-3-LN cells was significantly inhibited by gemcitabine combined with the sonic hedgehog inhibitor cyclopamine. The BxPC-3-LN cells expressed lower levels of let-7, miR-34, miR-107, miR-125, miR-128, miR-130, miR-132 and miR-141 than the parental BxPC-3 cells detected by microRNA PCR array, which were reported to have close relation to stem cell factors. This study provides evidence that cancer stem cells are the major sources of pancreatic cancer lymphatic metastasis, and microRNAs may regulate lymphatic metastasis in pancreatic cancer through modulating cancer stem cells.
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Copy and paste a formatted citation
Spandidos Publications style
Luo G, Long J, Cui X, Xiao Z, Liu Z, Shi S, Liu L, Liu C, Xu J, Li M, Li M, et al: Highly lymphatic metastatic pancreatic cancer cells possess stem cell-like properties. Int J Oncol 42: 979-984, 2013.
APA
Luo, G., Long, J., Cui, X., Xiao, Z., Liu, Z., Shi, S. ... Yu, X. (2013). Highly lymphatic metastatic pancreatic cancer cells possess stem cell-like properties. International Journal of Oncology, 42, 979-984. https://doi.org/10.3892/ijo.2013.1780
MLA
Luo, G., Long, J., Cui, X., Xiao, Z., Liu, Z., Shi, S., Liu, L., Liu, C., Xu, J., Li, M., Yu, X."Highly lymphatic metastatic pancreatic cancer cells possess stem cell-like properties". International Journal of Oncology 42.3 (2013): 979-984.
Chicago
Luo, G., Long, J., Cui, X., Xiao, Z., Liu, Z., Shi, S., Liu, L., Liu, C., Xu, J., Li, M., Yu, X."Highly lymphatic metastatic pancreatic cancer cells possess stem cell-like properties". International Journal of Oncology 42, no. 3 (2013): 979-984. https://doi.org/10.3892/ijo.2013.1780
Copy and paste a formatted citation
x
Spandidos Publications style
Luo G, Long J, Cui X, Xiao Z, Liu Z, Shi S, Liu L, Liu C, Xu J, Li M, Li M, et al: Highly lymphatic metastatic pancreatic cancer cells possess stem cell-like properties. Int J Oncol 42: 979-984, 2013.
APA
Luo, G., Long, J., Cui, X., Xiao, Z., Liu, Z., Shi, S. ... Yu, X. (2013). Highly lymphatic metastatic pancreatic cancer cells possess stem cell-like properties. International Journal of Oncology, 42, 979-984. https://doi.org/10.3892/ijo.2013.1780
MLA
Luo, G., Long, J., Cui, X., Xiao, Z., Liu, Z., Shi, S., Liu, L., Liu, C., Xu, J., Li, M., Yu, X."Highly lymphatic metastatic pancreatic cancer cells possess stem cell-like properties". International Journal of Oncology 42.3 (2013): 979-984.
Chicago
Luo, G., Long, J., Cui, X., Xiao, Z., Liu, Z., Shi, S., Liu, L., Liu, C., Xu, J., Li, M., Yu, X."Highly lymphatic metastatic pancreatic cancer cells possess stem cell-like properties". International Journal of Oncology 42, no. 3 (2013): 979-984. https://doi.org/10.3892/ijo.2013.1780
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