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Review

The RANKL/RANK system as a therapeutic target for bone invasion by oral squamous cell carcinoma (Review)

  • Authors:
    • Eijiro Jimi
    • Masashi Shin
    • Hiroyuki Furuta
    • Yukiyo Tada
    • Jingo Kusukawa
  • View Affiliations / Copyright

    Affiliations: Division of Molecular Signaling and Biochemistry, Department of Health Improvement, Kyushu Dental University, Kitakyushu, Fukuoka 803-8580, Japan, Department of Developmental Biology, Harvard School of Dental Medicine, Cambridge, MA 02142, USA, Dental and Oral Medical Center, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan
  • Pages: 803-809
    |
    Published online on: January 23, 2013
       https://doi.org/10.3892/ijo.2013.1794
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Abstract

Squamous cell carcinomas (SCCs) of the gingiva frequently invade the mandible or maxilla; this invasion is associated with a worse prognosis. The bone destruction associated with carcinomal invasion is mediated by osteoclasts rather than directly by the carcinoma. Therefore, if the cellular and molecular mechanisms by which oral SCC regulates bone invasion were known, it could inform the development of new therapeutic targets. Recently, dysregulation of the functional equilibrium in the receptor activator of NF-κB ligand (RANKL)/RANK/osteoprotegerin (OPG) triad has been shown to be responsible for osteolysis associated with the development of malignant tumors in bone sites. Furthermore, the administration of OPG or soluble RANK prevents bone metastasis by cancer cells. In this review, we discuss recent findings indicating that bone invasion by oral SCC is mediated via RANKL/RANK and may be successfully prevented by RANKL inhibition.
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Copy and paste a formatted citation
Spandidos Publications style
Jimi E, Shin M, Furuta H, Tada Y and Kusukawa J: The RANKL/RANK system as a therapeutic target for bone invasion by oral squamous cell carcinoma (Review). Int J Oncol 42: 803-809, 2013.
APA
Jimi, E., Shin, M., Furuta, H., Tada, Y., & Kusukawa, J. (2013). The RANKL/RANK system as a therapeutic target for bone invasion by oral squamous cell carcinoma (Review). International Journal of Oncology, 42, 803-809. https://doi.org/10.3892/ijo.2013.1794
MLA
Jimi, E., Shin, M., Furuta, H., Tada, Y., Kusukawa, J."The RANKL/RANK system as a therapeutic target for bone invasion by oral squamous cell carcinoma (Review)". International Journal of Oncology 42.3 (2013): 803-809.
Chicago
Jimi, E., Shin, M., Furuta, H., Tada, Y., Kusukawa, J."The RANKL/RANK system as a therapeutic target for bone invasion by oral squamous cell carcinoma (Review)". International Journal of Oncology 42, no. 3 (2013): 803-809. https://doi.org/10.3892/ijo.2013.1794
Copy and paste a formatted citation
x
Spandidos Publications style
Jimi E, Shin M, Furuta H, Tada Y and Kusukawa J: The RANKL/RANK system as a therapeutic target for bone invasion by oral squamous cell carcinoma (Review). Int J Oncol 42: 803-809, 2013.
APA
Jimi, E., Shin, M., Furuta, H., Tada, Y., & Kusukawa, J. (2013). The RANKL/RANK system as a therapeutic target for bone invasion by oral squamous cell carcinoma (Review). International Journal of Oncology, 42, 803-809. https://doi.org/10.3892/ijo.2013.1794
MLA
Jimi, E., Shin, M., Furuta, H., Tada, Y., Kusukawa, J."The RANKL/RANK system as a therapeutic target for bone invasion by oral squamous cell carcinoma (Review)". International Journal of Oncology 42.3 (2013): 803-809.
Chicago
Jimi, E., Shin, M., Furuta, H., Tada, Y., Kusukawa, J."The RANKL/RANK system as a therapeutic target for bone invasion by oral squamous cell carcinoma (Review)". International Journal of Oncology 42, no. 3 (2013): 803-809. https://doi.org/10.3892/ijo.2013.1794
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