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Article

S100A9 promotes the proliferation and invasion of HepG2 hepatocellular carcinoma cells via the activation of the MAPK signaling pathway

Corrigendum in: /10.3892/ijo.2023.5494
  • Authors:
    • Rui Wu
    • Liang Duan
    • Liwei Ye
    • Haiyang Wang
    • Xia Yang
    • Yunyuan  Zhang
    • Xian Chen
    • Yan Zhang
    • Yaguang Weng
    • Jingyong  Luo
    • Min  Tang
    • Qiong Shi
    • Tongchuan He
    • Lan Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, P.R. China, Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, IL 60637, USA
  • Pages: 1001-1010
    |
    Published online on: January 23, 2013
       https://doi.org/10.3892/ijo.2013.1796
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Abstract

The S100A9 protein, a member of the S100 protein family, is often upregulated in various types of cancer, including hepatocellular carcinoma (HCC). S100A9 acts as a danger signal when secreted to the extracellular space and is thought to play an important role during tumorigenesis. Despite this fact, little is known about the effects of S100A9 in the tumor microenvironment on HCC. Therefore, in this study, we investigated the effects of exogenous S100A9 on the proliferation and invasion of HepG2 HCC cells, as well as the molecular mechanisms underlying these effects. Our results demonstrated that exogenous S100A9 promoted the proliferation, clone formation and invasion of HepG2 cells in vitro, as shown by 3-(4,5-dimethyl­thiazol-2-yl)-2,5-diphenyltrazolium bromide (MTT), clone formation and transwell invasion assays, respectively, and also promoted tumor growth in vivo by tumorigenicity assays in nude mice. Furthermore, S100A9 increased the phosphorylation of p38 and ERK1/2 mitogen-activated protein kinases (MAPKs) in HepG2 cells. When the phosphorylation of p38 was inhibited by SB203580 (a p38 inhibitor), the S100A9-induced cell invasion was reversed; when the phosphorylation of ERK1/2 was inhibited by PD98059 (an ERK1/2 inhibitor), the S100A9-induced cell proliferation was reversed. These data suggest that the S100A9-induced proliferation and invasion of HepG2 cells are partly mediated by the activation of the MAPK signaling pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Wu R, Duan L, Ye L, Wang H, Yang X, Zhang Y, Chen X, Zhang Y, Weng Y, Luo J, Luo J, et al: S100A9 promotes the proliferation and invasion of HepG2 hepatocellular carcinoma cells via the activation of the MAPK signaling pathway Corrigendum in /10.3892/ijo.2023.5494. Int J Oncol 42: 1001-1010, 2013.
APA
Wu, R., Duan, L., Ye, L., Wang, H., Yang, X., Zhang, Y. ... Zhou, L. (2013). S100A9 promotes the proliferation and invasion of HepG2 hepatocellular carcinoma cells via the activation of the MAPK signaling pathway Corrigendum in /10.3892/ijo.2023.5494. International Journal of Oncology, 42, 1001-1010. https://doi.org/10.3892/ijo.2013.1796
MLA
Wu, R., Duan, L., Ye, L., Wang, H., Yang, X., Zhang, Y., Chen, X., Zhang, Y., Weng, Y., Luo, J., Tang, M., Shi, Q., He, T., Zhou, L."S100A9 promotes the proliferation and invasion of HepG2 hepatocellular carcinoma cells via the activation of the MAPK signaling pathway Corrigendum in /10.3892/ijo.2023.5494". International Journal of Oncology 42.3 (2013): 1001-1010.
Chicago
Wu, R., Duan, L., Ye, L., Wang, H., Yang, X., Zhang, Y., Chen, X., Zhang, Y., Weng, Y., Luo, J., Tang, M., Shi, Q., He, T., Zhou, L."S100A9 promotes the proliferation and invasion of HepG2 hepatocellular carcinoma cells via the activation of the MAPK signaling pathway Corrigendum in /10.3892/ijo.2023.5494". International Journal of Oncology 42, no. 3 (2013): 1001-1010. https://doi.org/10.3892/ijo.2013.1796
Copy and paste a formatted citation
x
Spandidos Publications style
Wu R, Duan L, Ye L, Wang H, Yang X, Zhang Y, Chen X, Zhang Y, Weng Y, Luo J, Luo J, et al: S100A9 promotes the proliferation and invasion of HepG2 hepatocellular carcinoma cells via the activation of the MAPK signaling pathway Corrigendum in /10.3892/ijo.2023.5494. Int J Oncol 42: 1001-1010, 2013.
APA
Wu, R., Duan, L., Ye, L., Wang, H., Yang, X., Zhang, Y. ... Zhou, L. (2013). S100A9 promotes the proliferation and invasion of HepG2 hepatocellular carcinoma cells via the activation of the MAPK signaling pathway Corrigendum in /10.3892/ijo.2023.5494. International Journal of Oncology, 42, 1001-1010. https://doi.org/10.3892/ijo.2013.1796
MLA
Wu, R., Duan, L., Ye, L., Wang, H., Yang, X., Zhang, Y., Chen, X., Zhang, Y., Weng, Y., Luo, J., Tang, M., Shi, Q., He, T., Zhou, L."S100A9 promotes the proliferation and invasion of HepG2 hepatocellular carcinoma cells via the activation of the MAPK signaling pathway Corrigendum in /10.3892/ijo.2023.5494". International Journal of Oncology 42.3 (2013): 1001-1010.
Chicago
Wu, R., Duan, L., Ye, L., Wang, H., Yang, X., Zhang, Y., Chen, X., Zhang, Y., Weng, Y., Luo, J., Tang, M., Shi, Q., He, T., Zhou, L."S100A9 promotes the proliferation and invasion of HepG2 hepatocellular carcinoma cells via the activation of the MAPK signaling pathway Corrigendum in /10.3892/ijo.2023.5494". International Journal of Oncology 42, no. 3 (2013): 1001-1010. https://doi.org/10.3892/ijo.2013.1796
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