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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2013 Volume 42 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

PRAF2 stimulates cell proliferation and migration and predicts poor prognosis in neuroblastoma

  • Authors:
    • Lisette P. Yco
    • Dirk Geerts
    • Jan Koster
    • André S. Bachmann
  • View Affiliations / Copyright

    Affiliations: Department of Pharmaceutical Sciences, College of Pharmacy, University of Hawaii at Hilo, Hilo, HI 96720, USA, Department of Human Genetics, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
  • Pages: 1408-1416
    |
    Published online on: February 21, 2013
       https://doi.org/10.3892/ijo.2013.1836
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Abstract

Prenylated Rab acceptor 1 domain family, member 2 (PRAF2) is a novel 19-kDa protein with four transmembrane-spanning domains that belongs to the PRAF protein family. Neuroblastoma (NB) is the most common malignant extracranial solid tumor of childhood that originates in primitive cells of the developing sympathetic nervous system. We investigated the correlation of PRAF2 mRNA expression to NB clinical and genetic parameters using Affymetrix expression analysis of a series of 88 NB tumors and examined the functional role of PRAF2 in an NB cell line using RNA interference. We found that high PRAF2 expression is significantly correlated to several unfavorable NB characteristics: MYCN amplification, high age at diagnosis, poor outcome and high INSS stage. The shRNA-mediated PRAF2 downregulation in the SK-N-SH NB cell line resulted in decreased cellular proliferation, migration and matrix-attachment. These findings were confirmed in NB patient tumor samples, where high PRAF2 expression is significantly correlated to bone and bone marrow metastasis, the main cause of death in NB patients. The present study shows that PRAF2 plays an essential role in NB tumorigenesis and metastasis.
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Copy and paste a formatted citation
Spandidos Publications style
Yco LP, Geerts D, Koster J and Bachmann AS: PRAF2 stimulates cell proliferation and migration and predicts poor prognosis in neuroblastoma. Int J Oncol 42: 1408-1416, 2013.
APA
Yco, L.P., Geerts, D., Koster, J., & Bachmann, A.S. (2013). PRAF2 stimulates cell proliferation and migration and predicts poor prognosis in neuroblastoma. International Journal of Oncology, 42, 1408-1416. https://doi.org/10.3892/ijo.2013.1836
MLA
Yco, L. P., Geerts, D., Koster, J., Bachmann, A. S."PRAF2 stimulates cell proliferation and migration and predicts poor prognosis in neuroblastoma". International Journal of Oncology 42.4 (2013): 1408-1416.
Chicago
Yco, L. P., Geerts, D., Koster, J., Bachmann, A. S."PRAF2 stimulates cell proliferation and migration and predicts poor prognosis in neuroblastoma". International Journal of Oncology 42, no. 4 (2013): 1408-1416. https://doi.org/10.3892/ijo.2013.1836
Copy and paste a formatted citation
x
Spandidos Publications style
Yco LP, Geerts D, Koster J and Bachmann AS: PRAF2 stimulates cell proliferation and migration and predicts poor prognosis in neuroblastoma. Int J Oncol 42: 1408-1416, 2013.
APA
Yco, L.P., Geerts, D., Koster, J., & Bachmann, A.S. (2013). PRAF2 stimulates cell proliferation and migration and predicts poor prognosis in neuroblastoma. International Journal of Oncology, 42, 1408-1416. https://doi.org/10.3892/ijo.2013.1836
MLA
Yco, L. P., Geerts, D., Koster, J., Bachmann, A. S."PRAF2 stimulates cell proliferation and migration and predicts poor prognosis in neuroblastoma". International Journal of Oncology 42.4 (2013): 1408-1416.
Chicago
Yco, L. P., Geerts, D., Koster, J., Bachmann, A. S."PRAF2 stimulates cell proliferation and migration and predicts poor prognosis in neuroblastoma". International Journal of Oncology 42, no. 4 (2013): 1408-1416. https://doi.org/10.3892/ijo.2013.1836
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