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Article Open Access

Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7

Erratum in: /ijo/44/5/1781
  • Authors:
    • Shujie Cheng
    • Isaac Eliaz
    • Junfang Lin
    • Daniel Sliva
  • View Affiliations / Copyright

    Affiliations: Department of Bioengineering, College of Food Science, South China Agricultural University, Guangzhou, P.R. China, Amitabha Medical Clinic and Healing Center, Sebastopol, CA, USA, Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, IN, USA
    Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 1869-1874
    |
    Published online on: April 16, 2013
       https://doi.org/10.3892/ijo.2013.1902
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Abstract

Poria cocos is a medicinal mushroom that is widely used in traditional Asian medicine. Here, we show that a characterized mixture of triterpenes extracted from P. cocos (PTE) and three purified triterpenes: pachymic acid (PA), dehydropachymic acid (DPA) and polyporenic acid C (PPAC) suppress the proliferation of the human pancreatic cancer cell lines Panc-1, MiaPaca-2, AsPc-1 and BxPc-3. Moreover, the most effective compound, PA, only slightly affects the proliferation of HPDE-6 normal pancreatic duct epithelial cells. The anti-proliferative effects of PTE on BxPc-3 cells are mediated by the cell cycle arrest at G0/G1 phase. DNA microarray analysis demonstrated that PTE significantly downregulates the expression of KRAS and matrix metalloproteinase-7 (MMP-7) in BxPc-3 cells. In addition, PTE and PA suppress the invasive behavior of BxPc-3 cells. The inhibition of invasiveness by PTE and PA was associated with the reduction of MMP-7 at the protein level and the role of MMP-7 further confirmed by the gene silencing of MMP-7 which also suppressed the invasiveness of BxPc-3 cells. In conclusion, triterpenes from P. cocos demonstrate anticancer and anti-invasive effects on human pancreatic cancer cells and can be considered as new therapeutic agents in the treatment of pancreatic cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Cheng S, Eliaz I, Lin J and Sliva D: Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7 Erratum in /ijo/44/5/1781 . Int J Oncol 42: 1869-1874, 2013.
APA
Cheng, S., Eliaz, I., Lin, J., & Sliva, D. (2013). Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7 Erratum in /ijo/44/5/1781 . International Journal of Oncology, 42, 1869-1874. https://doi.org/10.3892/ijo.2013.1902
MLA
Cheng, S., Eliaz, I., Lin, J., Sliva, D."Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7 Erratum in /ijo/44/5/1781 ". International Journal of Oncology 42.6 (2013): 1869-1874.
Chicago
Cheng, S., Eliaz, I., Lin, J., Sliva, D."Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7 Erratum in /ijo/44/5/1781 ". International Journal of Oncology 42, no. 6 (2013): 1869-1874. https://doi.org/10.3892/ijo.2013.1902
Copy and paste a formatted citation
x
Spandidos Publications style
Cheng S, Eliaz I, Lin J and Sliva D: Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7 Erratum in /ijo/44/5/1781 . Int J Oncol 42: 1869-1874, 2013.
APA
Cheng, S., Eliaz, I., Lin, J., & Sliva, D. (2013). Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7 Erratum in /ijo/44/5/1781 . International Journal of Oncology, 42, 1869-1874. https://doi.org/10.3892/ijo.2013.1902
MLA
Cheng, S., Eliaz, I., Lin, J., Sliva, D."Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7 Erratum in /ijo/44/5/1781 ". International Journal of Oncology 42.6 (2013): 1869-1874.
Chicago
Cheng, S., Eliaz, I., Lin, J., Sliva, D."Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7 Erratum in /ijo/44/5/1781 ". International Journal of Oncology 42, no. 6 (2013): 1869-1874. https://doi.org/10.3892/ijo.2013.1902
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