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Article

Effect of the STAT3 inhibitor STX-0119 on the proliferation of cancer stem-like cells derived from recurrent glioblastoma

  • Authors:
    • Tadashi Ashizawa
    • Haruo Miyata
    • Akira Iizuka
    • Masaru Komiyama
    • Chie Oshita
    • Akiko Kume
    • Masahiro Nogami
    • Mika Yagoto
    • Ichiro Ito
    • Takuma Oishi
    • Reiko Watanabe
    • Koichi Mitsuya
    • Kenji Matsuno
    • Toshio Furuya
    • Tadashi Okawara
    • Masami Otsuka
    • Naohisa Ogo
    • Akira Asai
    • Yoko Nakasu
    • Ken Yamaguchi
    • Yasuto Akiyama
  • View Affiliations / Copyright

    Affiliations: Immunotherapy Division, Shizuoka Cancer Center Research Institute, Shizuoka Cancer Center Hospital, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan, Division of Diagnostic Pathology, Shizuoka Cancer Center Hospital, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan, Division of Neurosurgery, Shizuoka Cancer Center Hospital, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Suruga-ku, Shizuoka 422-8526, Japan, PharmaDesign, Inc., Chuo-ku, Tokyo 104-0032, Japan, Kumamoto Health Science University, Kumamoto 861-5598, Japan, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan, Shizuoka Institute of Environment and Hygiene, Aoi-ku, Shizuoka 420-8637, Japan
  • Pages: 219-227
    |
    Published online on: April 23, 2013
       https://doi.org/10.3892/ijo.2013.1916
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Abstract

Signal transducer and activator of transcription (STAT) 3, a member of a family of DNA-binding molecules, is a potential target in the treatment of cancer. The highly phosphorylated STAT3 in cancer cells contributes to numerous physiological and oncogenic signaling pathways. Furthermore, a significant association between STAT3 signaling and glioblastoma multiforme stem-like cell (GBM-SC) development and maintenance has been demonstrated in recent studies. Previously, we reported a novel small molecule inhibitor of STAT3 dimerization, STX-0119, as a cancer therapeutic. In the present study, we focused on cancer stem-like cells derived from recurrent GBM patients and investigated the efficacy of STX-0119. Three GBM stem cell lines showed many stem cell markers such as CD133, EGFR, Nanog, Olig2, nestin and Yamanaka factors (c-myc, KLF4, Oct3/4 and SOX2) compared with parental cell lines. These cell lines also formed tumors in vivo and had similar histological to surgically resected tumors. STAT3 phosphorylation was activated more in the GBM-SC lines than serum-derived GB cell lines. The growth inhibitory effect of STX-0119 on GBM-SCs was moderate (IC50 15-44 µM) and stronger compared to that of WP1066 in two cell lines. On the other hand, the effect of temozolomide was weak in all the cell lines (IC50 53-226 µM). Notably, STX-0119 demonstrated strong inhibition of the expression of STAT3 target genes (c-myc, survivin, cyclin D1, HIF-1α and VEGF) and stem cell-associated genes (CD44, Nanog, nestin and CD133) as well as the induction of apoptosis in one stem-like cell line. Interestingly, VEGFR2 mRNA was also remarkably inhibited by STX-0119. In a model using transplantable stem-like cell lines in vivo GB-SCC010 and 026, STX-0119 inhibited the growth of GBM-SCs at 80 mg/kg. STX-0119, an inhibitor of STAT3, may serve as a novel therapeutic compound against GBM-SCs even in temozolomide-resistant GBM patients and has the potential for GBM-SC-specific therapeutics in combination with temozolomide plus radiation therapy.
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View References

1. 

Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, Curschmann J, Janzer RC, Ludwin SK, Gorlia T, Allgeier A, Lacombe D, Cairncross JG, Eisenhauer E and Mirimanoff RO: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 352:987–996. 2005. View Article : Google Scholar : PubMed/NCBI

2. 

Mirimanoff RO, Gorlia T, Mason W, Van den Bent MJ, Kortmann RD, Fisherb, Reni M, Brandes AA, Curschmann J, Villa S, Cairncross G, Allgerer A, Lacombe D and Stupp R: Radiotherapy and temozolomide for newly diagnosed glioblastoma: recursive partitioning analysis of the EORTC 26981/22981-NCIC CE3 phase III randomized trial. J Clin Oncol. 24:2563–2569. 2006. View Article : Google Scholar : PubMed/NCBI

3. 

Singh SK, Hawkins C, Clarke ID, Squire JA, Bayani J, Hide T, Henkeiman RM, Cusimano MD and Dirks PB: Identification of human tumor initiating cells. Nature. 432:396–401. 2004. View Article : Google Scholar : PubMed/NCBI

4. 

Galli R, Binda E, Orfanelli U, Cipelletti B, Gritti A, De Vitis S, Fiocco R, Foroni C, Dimeco F and Vescovi A: Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res. 64:7011–7021. 2004. View Article : Google Scholar : PubMed/NCBI

5. 

Singh SK, Clark ID, Terasaki M, Bonn VE, Hawkins C, Squire J and Dirks PB: Identification of a cancer stem cell in human brain tumors. Cancer Res. 63:5821–5828. 2003.PubMed/NCBI

6. 

Clark MF, Dick JE, Dirks PB, Eaves CJ, Jamieson CH, Jones DL, Visvader J, Weissman IL and Wahl GM: Cancer stem cells-perspectives on current status and future derections: AACR workshop on cancer stem cells. Cancer Res. 66:9339–9344. 2006. View Article : Google Scholar : PubMed/NCBI

7. 

Lee J, Kotliarova S, Kotliarov Y, Li A, Su Q, Donin NM, Pastorino S, Purow BW, Christopher N, Zhang W, Park JK and Fine HA: Tumor stem cells derived from glioblastomas cultures in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cells. 9:391–403. 2006. View Article : Google Scholar : PubMed/NCBI

8. 

Brennan C, Momota H, Hambardzumyan D, Ozawa T, Tandon A, Pedraza A and Holland E: Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations. PLoS One. 4:e77522009. View Article : Google Scholar : PubMed/NCBI

9. 

Cheng CK, Fan QW and Weiss WA: PI3K signaling in glioma-animal models and therapeutic challenges. Brain Pathol. 19:112–120. 2009. View Article : Google Scholar : PubMed/NCBI

10. 

Demuth T, Reavie LB, Rennert JL, Nakada M, Nakada S, Hoelzinger DB, Beaudry CE, Henrichs AN, Anderson EM and Berens ME: MAP-ing glioma invasion: mitogen-activated protein kinase 3 and p38 drive glioma invasion and progression and predict patient survival. Mol Cancer Ther. 6:1212–1222. 2007. View Article : Google Scholar : PubMed/NCBI

11. 

Pu P, Zhang Z, Kang C, Jiang R, Jia Z, Wang G and Jiang H: Downregulation of Wnt2 and beta-catenin by siRNA suppresses malignant glioma cell growth. Cancer Gene Ther. 16:351–361. 2009. View Article : Google Scholar : PubMed/NCBI

12. 

Purow BW, Haque RM, Noel MW, Su Q, Burdick MJ, Lee J, Sundaresan T, Pastorino S, Park JK, Mikolaenko I, Maric D, Eberhart CG and Fine HA: Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation. Cancer Res. 65:2353–2363. 2005. View Article : Google Scholar : PubMed/NCBI

13. 

Zhong Z, Wen L and Darnell JE Jr: Stat3 and Stat4: members of the family of signal transducers and activators of transcription. Proc Natl Acad Sci USA. 91:4806–4810. 1994. View Article : Google Scholar : PubMed/NCBI

14. 

Sherry MM, Reeves A, Wu JK and Cochran BH: STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells. Stem Cells. 27:2383–2392. 2009. View Article : Google Scholar : PubMed/NCBI

15. 

Li GH, Wei H, Lv SQ, Ji H and Wang DL: Knockdown of STAT3 expression by RNAi suppresses growth and induces apoptosis and differentiation in glioblastoma stem cells. Int J Oncol. 37:103–110. 2010.PubMed/NCBI

16. 

Ashizawa T, Miyata H, Ishii H, Oshita C, Matsuno K, Masuda Y, Furuya T, Okawara T, Otsuka M, Ogo N, Asai A and Akiyama Y: Antitumor activity of a novel small molecule STAT3 inhibitor against a human lymphoma cell line with high STAT3 activation. Int J Oncol. 38:1245–1252. 2011.PubMed/NCBI

17. 

Matsuno K, Masuda Y, Uehara Y, Sato H, Muroya A, Takahashi O, Yokotagawa T, Furuya T, Okawara T, Otsuka M, Ogo N, Ashizawa T, Oshita C, Tai S, Ishii H, Akiyama Y and Asai A: Identification of a new series of STAT3 inhibitors by virtual screening. ACS Med Chem Lett. 1:371–375. 2010. View Article : Google Scholar : PubMed/NCBI

18. 

Carro MS, Lim WK, Alvarez MJ, Bollo RJ, Zhao X, Snyder EY, Sulman EP, Anne SL, Doetsch F, Colman H, Lasorella A, Aldape K, Califano A and Lavarone A: Transcriptional network for mesenchymal transformation of brain tumors. Nature. 463:318–325. 2010. View Article : Google Scholar : PubMed/NCBI

19. 

Gao L, Zhang L, Hu J, Li F, Shao Y, Zhao Y, Kalvakolanu DV, Kopecko DJ, Zhao X and Xu DQ: Down-regulation of signal transducer and activator of transcription 3 expression using vector-based small interfering RNAs suppresses growth of human prostate tumor in vivo. Clin Cancer Res. 11:6333–6341. 2005. View Article : Google Scholar : PubMed/NCBI

20. 

Ling X and Arlinghaus RB: Knockdown of STAT3 expression by RNA interference inhibits the induction of breast tumors in immunocompetent mice. Cancer Res. 65:2532–2536. 2005. View Article : Google Scholar : PubMed/NCBI

21. 

Ohka F, Natsume A and Wakabayashi T: Current trends in targeted therapies for glioblastoma multiforme. Neurol Res Int. 2012. View Article : Google Scholar

22. 

Takizawa T, Nakashima K, Namihira M, Ochiai W, Uemura A, Yanagisawa M, Fujita N, Nakao M and Taga T: DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain. Dev Cell. 1:749–758. 2001. View Article : Google Scholar : PubMed/NCBI

23. 

De la Iglesia N, Konopka G, Puram SV, Chan JA, Bachoo RM, You MJ, Levy DE, Depinho RA and Bonni A: Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway. Genes Dev. 22:449–462. 2008.PubMed/NCBI

24. 

Ikushima H, Todo T, Ino Y, Takahashi M, Saito N, Miyazaki K and Miyazono K: Glioma-initiating cells retain their tumorigenicity through integration of the Sox axis and Oct4 protein. J Biol Chem. 286:41434–41441. 2011. View Article : Google Scholar : PubMed/NCBI

25. 

Guo Y, Mantel C, Hromas RA and Broxmeyer HE: Oct-4 is critical for survival/antiapoptosis of murine embryonic stem cells subjected to stress: effects associated with Stat3/survivin. Stem Cells. 26:30–34. 2008. View Article : Google Scholar : PubMed/NCBI

26. 

Zhao W, Hisamuddin IM, Nandan MO, Babbin BA, Lamb NE and Yang VW: Identification of Krüppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer. Oncogene. 23:395–402. 2004.

27. 

McFarland BC, Ma JY, Langford CP, Gillespie GY, Yu H, Zheng Y, Nozell SE, Huszar D and Benveniste EN: Therapeutic potential of AZD1480 for the treatment of human glioblastoma. Mol Cancer Ther. 10:2384–2393. 2011. View Article : Google Scholar : PubMed/NCBI

28. 

Sai K, Wang S, Balasubramaniyan V, Conrad C, Lang FF, Aldape K, Szymanski S, Fokt I, Dasgupta A, Madden T, Guan S and Chen Z: Induction of cell-cycle arrest and apoptosis in glioblastoma stem-like cells by WP1193, a novel small molecule inhibitor of the JAK2/STAT3 pathway. J Neurooncol. 107:487–501. 2012. View Article : Google Scholar : PubMed/NCBI

29. 

Ball S, Li C, Li PK and Lin J: The small molecule, LLL12, inhibits STAT3 phosphorylation and induces apoptosis in medulloblastoma and glioblastoma cells. PLoS One. 6:e188202011. View Article : Google Scholar : PubMed/NCBI

30. 

Zhuang W, Long L, Zheng B, Ji W, Yang N, Zhang Q and Liang Z: Curcumin promotes differentiation of glioma-initiating cells by inducing autophagy. Cancer Sci. 103:684–690. 2012. View Article : Google Scholar : PubMed/NCBI

31. 

Denysenko T, Gennero L, Roos MA, Melcarne A, Juenemann C, Faccani G, Morra I, Cavallo G, Reguzzi S, Pescarmona G and Ponzetto A: Glioblastoma cancer stem cells: heterogeneity, microenvironment and related therapeutic strategies. Cell Biochem Funct. 28:343–351. 2010. View Article : Google Scholar : PubMed/NCBI

32. 

Hofstetter CP, Burkhardt JK, Shin BJ, Gursel DB, Mubita L, Gorrepati R, Brennan C, Holland EC and Boockvar JA: Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia. PLoS One. 7:e300592012. View Article : Google Scholar : PubMed/NCBI

33. 

Wu Y, Richrad JP, Wang SD, Rath P, Laterra J and Xia S: Regulation of glioblastoma multiforme stem-like cells by inhibitor of DNA binding proteins and oligodendroglial lineage-associated transcription factors. Cancer Sci. 103:1028–1037. 2012. View Article : Google Scholar : PubMed/NCBI

34. 

Nguyen V, Conyers JM, Zhu D, Gibo DM, Dorsey JF, Debinski W and Mintz A: IL-13Rα2-targeted therapy escapees: biologic and therapeutic implications. Transl Oncol. 4:390–400. 2011.

35. 

Natsume A, Kato T, Kinjo S, Enomoto A, Toda H, Shimato S, Ohka F, Motomura K, Kondo Y, Miyata T, Takahashi M and Wakabayashi T: Girdin maintains the stemness of glioblastoma stem cells. Oncogene. 31:2715–2724. 2012. View Article : Google Scholar : PubMed/NCBI

36. 

Pistollato F, Abbadi S, Rampazzo E, Persano L, Della Puppa A, Frasson C, Sarto E, Scienza R, D’Avella D and Basso G: Intratumoral hypoxic gradient drives stem cells distribution and MGMT expression in glioblastoma. Stem Cells. 28:851–862. 2010.PubMed/NCBI

37. 

Qiang L, Wu T, Zhang HW, Lu N, Hu R, Wang YJ, Zhao L, Chen FH, Wang XT, You QD and Guo QL: HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway. Cell Death Differ. 19:284–294. 2012.

38. 

Ikushima H, Todo T, Ino Y, Takahashi M, Miyazawa K and Miyazono K: Autocrine TGF-β signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors. Cell Stem Cell. 5:504–514. 2009.

39. 

Kaur H, Phillips-Mason PJ, Burden-Gulley SM, Kerstetter-Fogle AE, Basilion JP, Sloan AE and Brady-Kalnay SM: Cadherin-11, a marker of the mesenchymal phenotype, regulates glioblastoma cell migration and survival in vivo. Mol Cancer Res. 10:293–304. 2012. View Article : Google Scholar : PubMed/NCBI

40. 

Cheng WY, Kandel JJ, Yamshiro DJ, Canoll P and Anastassiou D: A multi-cancer mesenchymal transition gene expression signature is associated with prolonged time to recurrence in glioblastoma. PLoS One. 7:e347052012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ashizawa T, Miyata H, Iizuka A, Komiyama M, Oshita C, Kume A, Nogami M, Yagoto M, Ito I, Oishi T, Oishi T, et al: Effect of the STAT3 inhibitor STX-0119 on the proliferation of cancer stem-like cells derived from recurrent glioblastoma. Int J Oncol 43: 219-227, 2013.
APA
Ashizawa, T., Miyata, H., Iizuka, A., Komiyama, M., Oshita, C., Kume, A. ... Akiyama, Y. (2013). Effect of the STAT3 inhibitor STX-0119 on the proliferation of cancer stem-like cells derived from recurrent glioblastoma. International Journal of Oncology, 43, 219-227. https://doi.org/10.3892/ijo.2013.1916
MLA
Ashizawa, T., Miyata, H., Iizuka, A., Komiyama, M., Oshita, C., Kume, A., Nogami, M., Yagoto, M., Ito, I., Oishi, T., Watanabe, R., Mitsuya, K., Matsuno, K., Furuya, T., Okawara, T., Otsuka, M., Ogo, N., Asai, A., Nakasu, Y., Yamaguchi, K., Akiyama, Y."Effect of the STAT3 inhibitor STX-0119 on the proliferation of cancer stem-like cells derived from recurrent glioblastoma". International Journal of Oncology 43.1 (2013): 219-227.
Chicago
Ashizawa, T., Miyata, H., Iizuka, A., Komiyama, M., Oshita, C., Kume, A., Nogami, M., Yagoto, M., Ito, I., Oishi, T., Watanabe, R., Mitsuya, K., Matsuno, K., Furuya, T., Okawara, T., Otsuka, M., Ogo, N., Asai, A., Nakasu, Y., Yamaguchi, K., Akiyama, Y."Effect of the STAT3 inhibitor STX-0119 on the proliferation of cancer stem-like cells derived from recurrent glioblastoma". International Journal of Oncology 43, no. 1 (2013): 219-227. https://doi.org/10.3892/ijo.2013.1916
Copy and paste a formatted citation
x
Spandidos Publications style
Ashizawa T, Miyata H, Iizuka A, Komiyama M, Oshita C, Kume A, Nogami M, Yagoto M, Ito I, Oishi T, Oishi T, et al: Effect of the STAT3 inhibitor STX-0119 on the proliferation of cancer stem-like cells derived from recurrent glioblastoma. Int J Oncol 43: 219-227, 2013.
APA
Ashizawa, T., Miyata, H., Iizuka, A., Komiyama, M., Oshita, C., Kume, A. ... Akiyama, Y. (2013). Effect of the STAT3 inhibitor STX-0119 on the proliferation of cancer stem-like cells derived from recurrent glioblastoma. International Journal of Oncology, 43, 219-227. https://doi.org/10.3892/ijo.2013.1916
MLA
Ashizawa, T., Miyata, H., Iizuka, A., Komiyama, M., Oshita, C., Kume, A., Nogami, M., Yagoto, M., Ito, I., Oishi, T., Watanabe, R., Mitsuya, K., Matsuno, K., Furuya, T., Okawara, T., Otsuka, M., Ogo, N., Asai, A., Nakasu, Y., Yamaguchi, K., Akiyama, Y."Effect of the STAT3 inhibitor STX-0119 on the proliferation of cancer stem-like cells derived from recurrent glioblastoma". International Journal of Oncology 43.1 (2013): 219-227.
Chicago
Ashizawa, T., Miyata, H., Iizuka, A., Komiyama, M., Oshita, C., Kume, A., Nogami, M., Yagoto, M., Ito, I., Oishi, T., Watanabe, R., Mitsuya, K., Matsuno, K., Furuya, T., Okawara, T., Otsuka, M., Ogo, N., Asai, A., Nakasu, Y., Yamaguchi, K., Akiyama, Y."Effect of the STAT3 inhibitor STX-0119 on the proliferation of cancer stem-like cells derived from recurrent glioblastoma". International Journal of Oncology 43, no. 1 (2013): 219-227. https://doi.org/10.3892/ijo.2013.1916
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