|
1.
|
Jemal A, Bray F, Center MM, Ferlay J, Ward
E and Forman D: Global cancer statistics. CA Cancer J Clin.
61:69–90. 2011. View Article : Google Scholar
|
|
2.
|
Forner A, Llovet JM and Bruix J:
Hepatocellular carcinoma. Lancet. 379:1245–1255. 2012. View Article : Google Scholar
|
|
3.
|
Eheman C, Henley SJ, Ballard-Barbash R, et
al: Annual Report to the Nation on the status of cancer, 1975–2008,
featuring cancers associated with excess weight and lack of
sufficient physical activity. Cancer. 118:2338–2366. 2012.
|
|
4.
|
Saika K and Matsuda T: Time trends in
liver cancer mortality (1980–2008) in Japan, the USA and Europe.
Jpn J Clin Oncol. 42:842012.
|
|
5.
|
Cao H, Phan H and Yang LX: Improved
chemotherapy for hepatocellular carcinoma. Anticancer Res.
32:1379–1386. 2012.PubMed/NCBI
|
|
6.
|
Zhang S, Doudican NA, Quay E and Orlow SJ:
Fluvastatin enhances sorafenib cytotoxicity in melanoma cells via
modulation of AKT and JNK signaling pathways. Anticancer Res.
31:3259–3265. 2011.PubMed/NCBI
|
|
7.
|
Hagman M, Hayes RA, Capon RJ and Shine R:
Alarm cues experienced by cane toad tadpoles affect
post-metamorphic morphology and chemical defences. Funct Ecol.
23:126–132. 2009. View Article : Google Scholar
|
|
8.
|
Gomes A, Bhattacharjee P, Mishra R, Biswas
AK, Dasgupta SC and Giri B: Anticancer potential of animal venoms
and toxins. Indian J Exp Biol. 48:93–103. 2010.
|
|
9.
|
Gao H, Popescu R, Kopp B and Wang Z:
Bufadienolides and their antitumor activity. Nat Prod Rep.
28:953–969. 2011. View Article : Google Scholar
|
|
10.
|
Qi F, Inagaki Y, Gao B, et al: Bufalin and
cinobufagin induce apoptosis of human hepatocellular carcinoma
cells via Fas- and mitochondria-mediated pathways. Cancer Sci.
102:951–958. 2011. View Article : Google Scholar
|
|
11.
|
Qi F, Li A, Inagaki Y, et al: Antitumor
activity of extracts and compounds from the skin of the toad Bufo
bufo gargarizans Cantor. Int Immunopharmacol. 11:342–349. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
12.
|
Xie CM, Chan WY, Yu S, Zhao J and Cheng
CH: Bufalin induces autophagy-mediated cell death in human colon
cancer cells through reactive oxygen species generation and JNK
activation. Free Radic Biol Med. 51:1365–1375. 2011. View Article : Google Scholar
|
|
13.
|
Gao Y, Li HX, Xu LT, et al: Bufalin
enhances the anti-proliferative effect of sorafenib on human
hepatocellular carcinoma cells through downregulation of ERK. Mol
Biol Rep. 39:1683–1689. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
14.
|
Chen A, Yu J, Zhang L, et al: Microarray
and biochemical analysis of bufalin-induced apoptosis of HL-60
cells. Biotechnol Lett. 31:487–494. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
15.
|
Takai N, Ueda T, Nishida M, Nasu K and
Narahara H: Bufalin induces growth inhibition, cell cycle arrest
and apoptosis in human endometrial and ovarian cancer cells. Int J
Mol Med. 21:637–643. 2008.PubMed/NCBI
|
|
16.
|
Berry DL and Baehrecke EH: Growth arrest
and autophagy are required for salivary gland cell degradation in
Drosophila. Cell. 131:1137–1148. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
17.
|
Cuervo AM and Macian F: Autophagy,
nutrition and immunology. Mol Aspects Med. 33:2–13. 2012.
View Article : Google Scholar
|
|
18.
|
Janku F, McConkey DJ, Hong DS and Kurzrock
R: Autophagy as a target for anticancer therapy. Nat Rev Clin
Oncol. 8:528–539. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
19.
|
Liu YL, Yang PM, Shun CT, Wu MS, Weng JR
and Chen CC: Autophagy potentiates the anti-cancer effects of the
histone deacetylase inhibitors in hepatocellular carcinoma.
Autophagy. 6:1057–1065. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
20.
|
Hsu CM, Hsu YA, Tsai Y, et al: Emodin
inhibits the growth of hepatoma cells: finding the common
anti-cancer pathway using Huh7, Hep3B and HepG2 cells. Biochem
Biophys Res Commun. 392:473–478. 2010. View Article : Google Scholar
|
|
21.
|
Takai N, Kira N, Ishii T, et al: Bufalin,
a traditional oriental medicine, induces apoptosis in human cancer
cells. Asian Pac J Cancer Prev. 13:399–402. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
22.
|
Li D, Qu X, Hou K, et al: PI3K/Akt is
involved in bufalin-induced apoptosis in gastric cancer cells.
Anticancer Drugs. 20:59–64. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
23.
|
Numazawa S, Shinoki MA, Ito H, Yoshida T
and Kuroiwa Y: Involvement of Na+, K(+)-ATPase inhibition in K562
cell differentiation induced by bufalin. J Cell Physiol.
160:113–120. 1994.
|
|
24.
|
Jing Y, Watabe M, Hashimoto S, Nakajo S
and Nakaya K: Cell cycle arrest and protein kinase modulating
effect of bufalin on human leukemia ML1 cells. Anticancer Res.
14:1193–1198. 1994.PubMed/NCBI
|
|
25.
|
Hong SH and Choi YH: Bufalin induces
apoptosis through activation of both the intrinsic and extrinsic
pathways in human bladder cancer cells. Oncol Rep. 27:114–120.
2012.PubMed/NCBI
|
|
26.
|
Zhu Z, Sun H, Ma G, Wang Z, Li E and Liu
Y: Bufalin induces lung cancer cell apoptosis via the inhibition of
PI3K/Akt pathway. Int J Mol Sci. 13:2025–2035. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
27.
|
Tsai SC, Yang JS, Peng SF, et al: Bufalin
increases sensitivity to AKT/mTOR-induced autophagic cell death in
SK-HEP-1 human hepatocellular carcinoma cells. Int J Oncol.
41:1431–1442. 2012.PubMed/NCBI
|
|
28.
|
Han KQ, Huang G, Gu W, Su YH, Huang XQ and
Ling CQ: Anti-tumor activities and apoptosis-regulated mechanisms
of bufalin on the orthotopic transplantation tumor model of human
hepatocellular carcinoma in nude mice. World J Gastroenterol.
13:3374–3379. 2007.
|
|
29.
|
Yu CH, Kan SF, Pu HF, Jea Chien E and Wang
PS: Apoptotic signaling in bufalin- and cinobufagin-treated
androgen-dependent and -independent human prostate cancer cells.
Cancer Sci. 99:2467–2476. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
30.
|
Wang N, Pan W, Zhu M, et al: Fangchinoline
induces autophagic cell death via p53/sestrin2/AMPK signalling in
human hepato-cellular carcinoma cells. Br J Pharmacol. 164:731–742.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
31.
|
Wang N, Feng Y, Zhu M, et al: Berberine
induces autophagic cell death and mitochondrial apoptosis in liver
cancer cells: the cellular mechanism. J Cell Biochem.
111:1426–1436. 2010. View Article : Google Scholar
|
|
32.
|
Pattingre S, Tassa A, Qu X, et al: Bcl-2
antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell.
122:927–939. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
33.
|
Motyl T, Gajkowska B, Zarzynska J,
Gajewska M and Lamparska-Przybysz M: Apoptosis and autophagy in
mammary gland remodeling and breast cancer chemotherapy. J Physiol
Pharmacol. 57(Suppl 7): 17–32. 2006.PubMed/NCBI
|
|
34.
|
Zhang DM, Liu JS, Tang MK, et al:
Bufotalin from Venenum Bufonis inhibits growth of multidrug
resistant HepG2 cells through G(2)/M cell cycle arrest and
apoptosis. Eur J Pharmacol. 692:19–28. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
35.
|
Trejo-Solis C, Jimenez-Farfan D,
Rodriguez-Enriquez S, et al: Copper compound induces autophagy and
apoptosis of glioma cells by reactive oxygen species and jnk
activation. BMC Cancer. 12:1562012. View Article : Google Scholar : PubMed/NCBI
|
|
36.
|
Zhang XQ, Dunner K Jr and Benedict WF:
Autophagy is induced by adenoviral-mediated interferon alpha
treatment in interferon resistant bladder cancer and normal
urothelial cells as a cell death protective mechanism but not by
the bystander factors produced. Cancer Gene Ther. 17:579–584. 2010.
View Article : Google Scholar
|
|
37.
|
Zhang L, Guo YF, Liu YZ, et al:
Pathway-based genome-wide association analysis identified the
importance of regulation-of-autophagy pathway for ultradistal
radius BMD. J Bone Miner Res. 25:1572–1580. 2010. View Article : Google Scholar
|
|
38.
|
Gao M, Yeh PY, Lu YS, et al: OSU-03012, a
novel celecoxib derivative, induces reactive oxygen species-related
autophagy in hepatocellular carcinoma. Cancer Res. 68:9348–9357.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
39.
|
Borsello T, Croquelois K, Hornung JP and
Clarke PG: N-methyld-aspartate-triggered neuronal death in
organotypic hippocampal cultures is endocytic, autophagic and
mediated by the c-Jun N-terminal kinase pathway. Eur J Neurosci.
18:473–485. 2003. View Article : Google Scholar
|
|
40.
|
Tanida I: Autophagosome formation and
molecular mechanism of autophagy. Antioxid Redox Signal.
14:2201–2214. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
41.
|
Chen C, Wang Y, Huang P and Liu-Chen LY:
Effects of C-terminal modifications of GEC1 protein and
gamma-aminobutyric acid type A (GABA(A)) receptor-associated
protein (GABARAP), two microtubule-associated proteins, on kappa
opioid receptor expression. J Biol Chem. 286:15106–15115. 2011.
View Article : Google Scholar
|
|
42.
|
Kawazoe N, Watabe M, Masuda Y, Nakajo S
and Nakaya K: Tiam1 is involved in the regulation of
bufalin-induced apoptosis in human leukemia cells. Oncogene.
18:2413–2421. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
43.
|
Li DD, Wang LL, Deng R, et al: The pivotal
role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression
during anti-cancer agents-induced autophagy in cancer cells.
Oncogene. 28:886–898. 2009. View Article : Google Scholar
|
|
44.
|
Byun JY, Yoon CH, An S, et al: The
Rac1/MKK7/JNK pathway signals upregulation of Atg5 and subsequent
autophagic cell death in response to oncogenic Ras. Carcinogenesis.
30:1880–1888. 2009. View Article : Google Scholar : PubMed/NCBI
|
