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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 2013 Volume 43 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

PDCD5 expression predicts a favorable outcome in patients with hepatocellular carcinoma

  • Authors:
    • Da-Zhi Fu
    • Ying Cheng
    • Hui He
    • Hai-Yang Liu
    • Yong-Feng Liu
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning, P.R. China
  • Pages: 821-830
    |
    Published online on: June 26, 2013
       https://doi.org/10.3892/ijo.2013.1993
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Abstract

Liver cancer in men is the fifth most frequently diagnosed cancer worldwide. Programmed cell death 5 (PDCD5) is an apoptosis related gene and plays an important role in the pathogenesis and development of cancer. In this study, we confirmed that the levels of PDCD5 mRNA and protein were lower in hepatocellular carcinoma (HCC) tissue compared to normal tissue. PDCD5 expression was significantly associated with HBV infection, tumor number, lymph node metastasis and the survival time of the patients with HCC. In addition, the serum levels of PDCD5 and AFP in the patients were significantly positively correlated. We also confirmed that upregulation of PDCD5 was able to inhibit cell proliferation and mobility, induce apoptosis and G1 arrest. Interestingly, PDCD5 also inhibited proteasome activity similarly to the proteosome inhibitor MG132. PDCD5 could be considered as a reliable marker of favorable prognosis of HCC patients.
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Copy and paste a formatted citation
Spandidos Publications style
Fu D, Cheng Y, He H, Liu H and Liu Y: PDCD5 expression predicts a favorable outcome in patients with hepatocellular carcinoma. Int J Oncol 43: 821-830, 2013.
APA
Fu, D., Cheng, Y., He, H., Liu, H., & Liu, Y. (2013). PDCD5 expression predicts a favorable outcome in patients with hepatocellular carcinoma. International Journal of Oncology, 43, 821-830. https://doi.org/10.3892/ijo.2013.1993
MLA
Fu, D., Cheng, Y., He, H., Liu, H., Liu, Y."PDCD5 expression predicts a favorable outcome in patients with hepatocellular carcinoma". International Journal of Oncology 43.3 (2013): 821-830.
Chicago
Fu, D., Cheng, Y., He, H., Liu, H., Liu, Y."PDCD5 expression predicts a favorable outcome in patients with hepatocellular carcinoma". International Journal of Oncology 43, no. 3 (2013): 821-830. https://doi.org/10.3892/ijo.2013.1993
Copy and paste a formatted citation
x
Spandidos Publications style
Fu D, Cheng Y, He H, Liu H and Liu Y: PDCD5 expression predicts a favorable outcome in patients with hepatocellular carcinoma. Int J Oncol 43: 821-830, 2013.
APA
Fu, D., Cheng, Y., He, H., Liu, H., & Liu, Y. (2013). PDCD5 expression predicts a favorable outcome in patients with hepatocellular carcinoma. International Journal of Oncology, 43, 821-830. https://doi.org/10.3892/ijo.2013.1993
MLA
Fu, D., Cheng, Y., He, H., Liu, H., Liu, Y."PDCD5 expression predicts a favorable outcome in patients with hepatocellular carcinoma". International Journal of Oncology 43.3 (2013): 821-830.
Chicago
Fu, D., Cheng, Y., He, H., Liu, H., Liu, Y."PDCD5 expression predicts a favorable outcome in patients with hepatocellular carcinoma". International Journal of Oncology 43, no. 3 (2013): 821-830. https://doi.org/10.3892/ijo.2013.1993
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