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‘Decoy’ and ‘non-decoy’ functions of DcR3 promote malignant potential in human malignant fibrous histiocytoma cells

  • Authors:
    • Mitsunori Toda
    • Teruya Kawamoto
    • Takeshi Ueha
    • Kenta Kishimoto
    • Hitomi Hara
    • Naomasa Fukase
    • Yasuo Onishi
    • Risa Harada
    • Masaya Minoda
    • Masahiro Kurosaka
    • Toshihiro Akisue
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Chuo-ku, Kobe 650-0017, Japan, NeoChemir Inc., Sannomiya Chuo-building 4F, Chuo-ku, Kobe 651-0087, Japan
    Copyright: © Toda et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 703-712
    |
    Published online on: June 28, 2013
       https://doi.org/10.3892/ijo.2013.1999
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Abstract

Decoy receptor 3 (DcR3) is a soluble secreted protein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. DcR3 inhibits the Fas ligand (FasL)/Fas apoptotic pathway by binding to FasL, competitively with Fas receptor. Previous studies have reported that overexpression of DcR3 has been detected in various human malignancies and that DcR3 functions as a ‘decoy’ for FasL to inhibit FasL-induced apoptosis. In addition, recent studies have revealed that DcR3 has ‘non-decoy’ functions to promote tumor cell migration and invasion, suggesting that DcR3 may play important roles in tumor progression by decoy and non-decoy functions. We have previously reported that overexpression of DcR3 was observed in human malignant fibrous histiocytoma (MFH), however, the roles of DcR3 in MFH have not been studied. In the present study, to elucidate the roles of DcR3 in tumor progression of MFH, we examined the effects of DcR3 inhibition on cell apoptosis, migration and invasion in human MFH cells. siRNA knockdown of DcR3 enhanced the FasL-induced apoptotic activity and significantly decreased cell migration and invasion with a decrease in the activation of phosphatidylinositol 3 kinase (PI3K)/Akt and matrix metalloproteinase (MMP)-2. The findings in this study strongly suggest that DcR3 plays important roles in tumor progression of human MFH by decoy as well as non-decoy functions and that DcR3 may serve as a potent therapeutic target for human MFH.
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1 

Spira AI and Ettinger DS: The use of chemotherapy in soft-tissue sarcomas. Oncologist. 7:348–359. 2002. View Article : Google Scholar : PubMed/NCBI

2 

Matushansky I, Charytonowicz E, Mills J, Siddiqi S, Hricik T and Cordon-Cardo C: MFH classification: differentiating undifferentiated pleomorphic sarcoma in the 21st Century. Expert Rev Anticancer Ther. 9:1135–1144. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Papai Z, Bodoky G, Szanto J, et al: The efficacy of a combination of etoposide, ifosfamide and cisplatin in the treatment of patients with soft tissue sarcoma. Cancer. 89:177–180. 2000. View Article : Google Scholar : PubMed/NCBI

4 

Jain A, Sajeevan K, Babu K and Lakshmaiah K: Chemotherapy in adult soft tissue sarcoma. Indian J Cancer. 46:274–287. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Pitti RM, Marsters SA, Lawrence DA, et al: Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer. Nature. 396:699–703. 1998. View Article : Google Scholar : PubMed/NCBI

6 

Yu KY, Kwon B, Ni J, Zhai Y, Ebner R and Kwon BS: A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis. J Biol Chem. 274:13733–13736. 1999. View Article : Google Scholar : PubMed/NCBI

7 

Migone TS, Zhang J, Luo X, et al: TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. Immunity. 16:479–492. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Hanahan D and Weinberg RA: The hallmarks of cancer. Cell. 100:57–70. 2000. View Article : Google Scholar

9 

Strasser A, Jost PJ and Nagata S: The many roles of FAS receptor signaling in the immune system. Immunity. 30:180–192. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Ho CH, Chen CL, Li WY and Chen CJ: Decoy receptor 3, upregulated by Epstein-Barr virus latent membrane protein 1, enhances nasopharyngeal carcinoma cell migration and invasion. Carcinogenesis. 30:1443–1451. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Ge Z, Sanders AJ, Ye L, Wang Y and Jiang WG: Expression of death decoy receptor-3 (DcR3) in human breast cancer and its functional effects on breast cancer cells in vitro. J Exp Ther Oncol. 9:109–118. 2011.PubMed/NCBI

12 

Yang CR, Hsieh SL, Teng CM, Ho FM, Su WL and Lin WW: Soluble decoy receptor 3 induces angiogenesis by neutralization of TL1A, a cytokine belonging to tumor necrosis factor superfamily and exhibiting angiostatic action. Cancer Res. 64:1122–1129. 2004. View Article : Google Scholar

13 

Yang CR, Wang JH, Hsieh SL, Wang SM, Hsu TL and Lin WW: Decoy receptor 3 (DcR3) induces osteoclast formation from monocyte/macrophage lineage precursor cells. Cell Death Differ. 11(Suppl 1): S97–S107. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Wu SF, Liu TM, Lin YC, et al: Immunomodulatory effect of decoy receptor 3 on the differentiation and function of bone marrow-derived dendritic cells in nonobese diabetic mice: from regulatory mechanism to clinical implication. J Leukoc Biol. 75:293–306. 2004.

15 

Hayashi S, Nishiyama T, Miura Y, et al: DcR3 induces cell proliferation through MAPK signaling in chondrocytes of osteoarthritis. Osteoarthritis Cartilage. 19:903–910. 2011. View Article : Google Scholar : PubMed/NCBI

16 

You RI, Chang YC, Chen PM, et al: Apoptosis of dendritic cells induced by decoy receptor 3 (DcR3). Blood. 111:1480–1488. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Hsu MJ, Lin WW, Tsao WC, et al: Enhanced adhesion of monocytes via reverse signaling triggered by decoy receptor 3. Exp Cell Res. 292:241–251. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Ohshima K, Haraoka S, Sugihara M, et al: Amplification and expression of a decoy receptor for fas ligand (DcR3) in virus (EBV or HTLV-I) associated lymphomas. Cancer Lett. 160:89–97. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Roth W, Isenmann S, Nakamura M, et al: Soluble decoy receptor 3 is expressed by malignant gliomas and suppresses CD95 ligand-induced apoptosis and chemotaxis. Cancer Res. 61:2759–2765. 2001.PubMed/NCBI

20 

Tsuji S, Hosotani R, Yonehara S, et al: Endogenous decoy receptor 3 blocks the growth inhibition signals mediated by Fas ligand in human pancreatic adenocarcinoma. Int J Cancer. 106:17–25. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Imabori M, Akisue T, Kishimoto K, et al: Expression of DcR3 in bone and soft tissue tumors. Cancer Ther. 7:43–48. 2009.

22 

Macher-Goeppinger S, Aulmann S, Wagener N, et al: Decoy receptor 3 is a prognostic factor in renal cell cancer. Neoplasia. 10:1049–1056. 2008.PubMed/NCBI

23 

Chen G and Luo D: Over-expression of decoy receptor 3 in gastric precancerous lesions and carcinoma. Ups J Med Sci. 113:297–304. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Chen G and Luo D: Expression of decoy receptor 3 in liver tissue microarrays. Natl Med J India. 21:275–278. 2008.PubMed/NCBI

25 

Chang PM, Chen PM, Hsieh SL, et al: Expression of a soluble decoy receptor 3 in patients with diffuse large B-cell lymphoma predicts clinical outcome. Int J Oncol. 33:549–554. 2008.PubMed/NCBI

26 

Fujita Y, Sakakura C, Shimomura K, et al: Chromosome arm 20q gains and other genomic alterations in esophageal squamous cell carcinoma, as analyzed by comparative genomic hybridization and fluorescence in situ hybridization. Hepatogastroenterology. 50:1857–1863. 2003.

27 

Takahama Y, Yamada Y, Emoto K, et al: The prognostic significance of overexpression of the decoy receptor for Fas ligand (DcR3) in patients with gastric carcinomas. Gastric Cancer. 5:61–68. 2002. View Article : Google Scholar : PubMed/NCBI

28 

Choong PFM: The molecular basis of skeletal metastases. Clin Orthop Relat Res. 415:S192003. View Article : Google Scholar

29 

Hidalgo M and Eckhardt SG: Development of matrix metalloproteinase inhibitors in cancer therapy. J Natl Cancer Inst. 93:178–193. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Egeblad M and Werb Z: New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer. 2:163–176. 2002. View Article : Google Scholar

31 

Ohnishi Y, Ito Y, Tajima S, Ishibashi A and Arai K: Immunohistochemical study of membrane type-matrix metalloproteinases (MT-MMPs) and matrix metalloproteinase-2 (MMP-2) in dermatofibroma and malignant fibrous histiocytoma. J Dermatol Sci. 28:119–125. 2002. View Article : Google Scholar

32 

Ahlen J, Enberg U, Larsson C, et al: Malignant fibrous histiocytoma, aggressive fibromatosis and benign fibrous tumors express mRNA for the metalloproteinase inducer EMMPRIN and the metalloproteinases MMP-2 and MT1-MMP. Sarcoma. 5:143–149. 2001. View Article : Google Scholar

33 

Nakatani T, Marui T, Yamamoto T, Kurosaka M, Akisue T and Matsumoto K: Establishment and characterization of cell line TNMY1 derived from human malignant fibrous histiocytoma. Pathol Int. 51:595–602. 2001. View Article : Google Scholar : PubMed/NCBI

34 

Kiyozuka Y, Nakagawa H, Uemura Y, et al: Novel cell lines established from a human myxoid malignant fibrous histiocytoma arising in the uterus. Cancer Genet Cytogenet. 127:7–15. 2001. View Article : Google Scholar : PubMed/NCBI

35 

Liang CC, Park AY and Guan JL: In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc. 2:329–333. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Albini A: Tumor and endothelial cell invasion of basement membranes. The matrigel chemoinvasion assay as a tool for dissecting molecular mechanisms. Pathol Oncol Res. 4:230–241. 1998. View Article : Google Scholar : PubMed/NCBI

37 

Troeberg L and Nagase H: Zymography of metalloproteinases. Curr Protoc Protein Sci. Chapter 21(Unit 21): 152004.PubMed/NCBI

38 

Yang CR, Guh JH, Teng CM, Chen CC and Chen PH: Combined treatment with denbinobin and Fas ligand has a synergistic cytotoxic effect in human pancreatic adenocarcinoma BxPC-3 cells. Br J Pharmacol. 157:1175–1185. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Reuben PM and Cheung HS: Regulation of matrix metalloproteinase (MMP) gene expression by protein kinases. Front Biosci. 11:1199–1215. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Kim R, Emi M and Tanabe K: Cancer immunoediting from immune surveillance to immune escape. Immunology. 121:1–14. 2007. View Article : Google Scholar : PubMed/NCBI

41 

Yang D, Fan X, Yin P, et al: Significance of decoy receptor 3 (Dcr3) and external-signal regulated kinase 1/2 (Erk1/2) in gastric cancer. BMC Immunol. 13:282012. View Article : Google Scholar : PubMed/NCBI

42 

Chin YR and Toker A: Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer. Cell Signal. 21:470–476. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Sun M, Wang G, Paciga JE, et al: AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells. Am J Pathol. 159:431–437. 2001. View Article : Google Scholar : PubMed/NCBI

44 

Staal SP: Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma. Proc Natl Acad Sci USA. 84:5034–5037. 1987. View Article : Google Scholar : PubMed/NCBI

45 

Kessenbrock K, Plaks V and Werb Z: Matrix metalloproteinases: regulators of the tumor microenvironment. Cell. 141:52–67. 2010. View Article : Google Scholar : PubMed/NCBI

46 

Morrison CJ, Butler GS, Bigg HF, Roberts CR, Soloway PD and Overall CM: Cellular activation of MMP-2 (gelatinase A) by MT2-MMP occurs via a TIMP-2-independent pathway. J Biol Chem. 276:47402–47410. 2001. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Toda M, Kawamoto T, Ueha T, Kishimoto K, Hara H, Fukase N, Onishi Y, Harada R, Minoda M, Kurosaka M, Kurosaka M, et al: ‘Decoy’ and ‘non-decoy’ functions of DcR3 promote malignant potential in human malignant fibrous histiocytoma cells. Int J Oncol 43: 703-712, 2013.
APA
Toda, M., Kawamoto, T., Ueha, T., Kishimoto, K., Hara, H., Fukase, N. ... Akisue, T. (2013). ‘Decoy’ and ‘non-decoy’ functions of DcR3 promote malignant potential in human malignant fibrous histiocytoma cells. International Journal of Oncology, 43, 703-712. https://doi.org/10.3892/ijo.2013.1999
MLA
Toda, M., Kawamoto, T., Ueha, T., Kishimoto, K., Hara, H., Fukase, N., Onishi, Y., Harada, R., Minoda, M., Kurosaka, M., Akisue, T."‘Decoy’ and ‘non-decoy’ functions of DcR3 promote malignant potential in human malignant fibrous histiocytoma cells". International Journal of Oncology 43.3 (2013): 703-712.
Chicago
Toda, M., Kawamoto, T., Ueha, T., Kishimoto, K., Hara, H., Fukase, N., Onishi, Y., Harada, R., Minoda, M., Kurosaka, M., Akisue, T."‘Decoy’ and ‘non-decoy’ functions of DcR3 promote malignant potential in human malignant fibrous histiocytoma cells". International Journal of Oncology 43, no. 3 (2013): 703-712. https://doi.org/10.3892/ijo.2013.1999
Copy and paste a formatted citation
x
Spandidos Publications style
Toda M, Kawamoto T, Ueha T, Kishimoto K, Hara H, Fukase N, Onishi Y, Harada R, Minoda M, Kurosaka M, Kurosaka M, et al: ‘Decoy’ and ‘non-decoy’ functions of DcR3 promote malignant potential in human malignant fibrous histiocytoma cells. Int J Oncol 43: 703-712, 2013.
APA
Toda, M., Kawamoto, T., Ueha, T., Kishimoto, K., Hara, H., Fukase, N. ... Akisue, T. (2013). ‘Decoy’ and ‘non-decoy’ functions of DcR3 promote malignant potential in human malignant fibrous histiocytoma cells. International Journal of Oncology, 43, 703-712. https://doi.org/10.3892/ijo.2013.1999
MLA
Toda, M., Kawamoto, T., Ueha, T., Kishimoto, K., Hara, H., Fukase, N., Onishi, Y., Harada, R., Minoda, M., Kurosaka, M., Akisue, T."‘Decoy’ and ‘non-decoy’ functions of DcR3 promote malignant potential in human malignant fibrous histiocytoma cells". International Journal of Oncology 43.3 (2013): 703-712.
Chicago
Toda, M., Kawamoto, T., Ueha, T., Kishimoto, K., Hara, H., Fukase, N., Onishi, Y., Harada, R., Minoda, M., Kurosaka, M., Akisue, T."‘Decoy’ and ‘non-decoy’ functions of DcR3 promote malignant potential in human malignant fibrous histiocytoma cells". International Journal of Oncology 43, no. 3 (2013): 703-712. https://doi.org/10.3892/ijo.2013.1999
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