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Article

Mucin-like peptides from Echinococcus granulosus induce antitumor activity

  • Authors:
    • Verónica Noya
    • Sylvie Bay
    • María Florencia Festari
    • Enrique P. García
    • Ernesto Rodriguez
    • Carolina Chiale
    • Christelle Ganneau
    • Françoise Baleux
    • Soledad Astrada
    • Mariela Bollati-Fogolín
    • Eduardo Osinaga
    • Teresa Freire
  • View Affiliations / Copyright

    Affiliations: Department of Immunobiology, School of Medicine, UdelaR, 11800 Montevideo, Uruguay, Department of Structure and Chemical Biology, Unit of Biomolecule Chemistry, Institut Pasteur, 75724 Paris Cedex 15, France, Cell Biology Unit, Institut Pasteur Montevideo, Mataojo 2020, 11400 Montevideo, Uruguay
  • Pages: 775-784
    |
    Published online on: June 28, 2013
       https://doi.org/10.3892/ijo.2013.2000
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Abstract

There is substantial evidence suggesting that certain parasites can have antitumor properties. We evaluated mucin peptides derived from the helminth Echinococcus granulosus (denominated Egmuc) as potential inducers of antitumor activity. We present data showing that Egmuc peptides were capable of inducing an increase of activated NK cells in the spleen of immunized mice, a fact that was correlated with the capacity of splenocytes to mediate killing of tumor cells. We demonstrated that Egmuc peptides enhance LPS-induced maturation of dendritic cells in vitro by increasing the production of IL-12p40p70 and IL-6 and that Egmuc-treated DCs may activate NK cells, as judged by an increased expression of CD69. This evidence may contribute to the design of tumor vaccines and open new horizons in the use of parasite-derived molecules in the fight against cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Noya V, Bay S, Festari MF, García EP, Rodriguez E, Chiale C, Ganneau C, Baleux F, Astrada S, Bollati-Fogolín M, Bollati-Fogolín M, et al: Mucin-like peptides from Echinococcus granulosus induce antitumor activity. Int J Oncol 43: 775-784, 2013.
APA
Noya, V., Bay, S., Festari, M.F., García, E.P., Rodriguez, E., Chiale, C. ... Freire, T. (2013). Mucin-like peptides from Echinococcus granulosus induce antitumor activity. International Journal of Oncology, 43, 775-784. https://doi.org/10.3892/ijo.2013.2000
MLA
Noya, V., Bay, S., Festari, M. F., García, E. P., Rodriguez, E., Chiale, C., Ganneau, C., Baleux, F., Astrada, S., Bollati-Fogolín, M., Osinaga, E., Freire, T."Mucin-like peptides from Echinococcus granulosus induce antitumor activity". International Journal of Oncology 43.3 (2013): 775-784.
Chicago
Noya, V., Bay, S., Festari, M. F., García, E. P., Rodriguez, E., Chiale, C., Ganneau, C., Baleux, F., Astrada, S., Bollati-Fogolín, M., Osinaga, E., Freire, T."Mucin-like peptides from Echinococcus granulosus induce antitumor activity". International Journal of Oncology 43, no. 3 (2013): 775-784. https://doi.org/10.3892/ijo.2013.2000
Copy and paste a formatted citation
x
Spandidos Publications style
Noya V, Bay S, Festari MF, García EP, Rodriguez E, Chiale C, Ganneau C, Baleux F, Astrada S, Bollati-Fogolín M, Bollati-Fogolín M, et al: Mucin-like peptides from Echinococcus granulosus induce antitumor activity. Int J Oncol 43: 775-784, 2013.
APA
Noya, V., Bay, S., Festari, M.F., García, E.P., Rodriguez, E., Chiale, C. ... Freire, T. (2013). Mucin-like peptides from Echinococcus granulosus induce antitumor activity. International Journal of Oncology, 43, 775-784. https://doi.org/10.3892/ijo.2013.2000
MLA
Noya, V., Bay, S., Festari, M. F., García, E. P., Rodriguez, E., Chiale, C., Ganneau, C., Baleux, F., Astrada, S., Bollati-Fogolín, M., Osinaga, E., Freire, T."Mucin-like peptides from Echinococcus granulosus induce antitumor activity". International Journal of Oncology 43.3 (2013): 775-784.
Chicago
Noya, V., Bay, S., Festari, M. F., García, E. P., Rodriguez, E., Chiale, C., Ganneau, C., Baleux, F., Astrada, S., Bollati-Fogolín, M., Osinaga, E., Freire, T."Mucin-like peptides from Echinococcus granulosus induce antitumor activity". International Journal of Oncology 43, no. 3 (2013): 775-784. https://doi.org/10.3892/ijo.2013.2000
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