CEACAM6 induces epithelial-mesenchymal transition and mediates invasion and metastasis in pancreatic cancer

  • Authors:
    • Jianmin Chen
    • Qiang Li
    • Yong An
    • Nan Lv
    • Xiaofeng Xue
    • Jishu Wei
    • Kuirong Jiang
    • Junli Wu
    • Wentao Gao
    • Zhuyin Qian
    • Cuncai Dai
    • Zekuan Xu
    • Yi Miao
  • View Affiliations

  • Published online on: July 12, 2013     https://doi.org/10.3892/ijo.2013.2015
  • Pages: 877-885
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Abstract

Pancreatic cancer is a disease with an extremely poor prognosis. The acquisition of invasion properties in pancreatic cancer is accompanied by the process of epithelial-mesenchymal transition (EMT). Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is emerging as an important determinant of the malignant phenotype in a range of cancers, including pancreatic cancer. Therefore, the aim of this study was to evaluate the potential involvement of CEACAM6 in the invasion and metastasis of pancreatic cancer cells via EMT regulation. The results of our study showed a positive association between CEACAM6 expression and poor prognosis of pancreatic cancer, differentiation and lymph node metastasis. Elevated levels of CEACAM6 in pancreatic cancer cells promoted EMT, migration and invasion in vitro and metastasis in animal models, whereas shRNA-mediated CEACAM6 knockdown had the opposite effect. Furthermore, we demonstrated that miR-29a/b/c specific for CEACAM6 could regulate its expression at the post-transcriptional level. Collectively, our findings identified CEACAM6, which is regulated by miR-29a/b/c, as an important positive regulator of EMT in pancreatic cancer offering an explanation for how elevated levels of CEACAM6 are likely to contribute to the highly metastatic phenotype of pancreatic cancer.
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September 2013
Volume 43 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Chen J, Li Q, An Y, Lv N, Xue X, Wei J, Jiang K, Wu J, Gao W, Qian Z, Qian Z, et al: CEACAM6 induces epithelial-mesenchymal transition and mediates invasion and metastasis in pancreatic cancer. Int J Oncol 43: 877-885, 2013
APA
Chen, J., Li, Q., An, Y., Lv, N., Xue, X., Wei, J. ... Miao, Y. (2013). CEACAM6 induces epithelial-mesenchymal transition and mediates invasion and metastasis in pancreatic cancer. International Journal of Oncology, 43, 877-885. https://doi.org/10.3892/ijo.2013.2015
MLA
Chen, J., Li, Q., An, Y., Lv, N., Xue, X., Wei, J., Jiang, K., Wu, J., Gao, W., Qian, Z., Dai, C., Xu, Z., Miao, Y."CEACAM6 induces epithelial-mesenchymal transition and mediates invasion and metastasis in pancreatic cancer". International Journal of Oncology 43.3 (2013): 877-885.
Chicago
Chen, J., Li, Q., An, Y., Lv, N., Xue, X., Wei, J., Jiang, K., Wu, J., Gao, W., Qian, Z., Dai, C., Xu, Z., Miao, Y."CEACAM6 induces epithelial-mesenchymal transition and mediates invasion and metastasis in pancreatic cancer". International Journal of Oncology 43, no. 3 (2013): 877-885. https://doi.org/10.3892/ijo.2013.2015