Anti-proliferative effect of honokiol in oral squamous cancer through the regulation of specificity protein 1

  • Authors:
    • Dong-Wook Kim
    • Seon Mi Ko
    • Young-Joo Jeon
    • Young-Woock Noh
    • Nag-Jin Choi
    • Sung-Dae Cho
    • Hong Seop Moon
    • Young Sik Cho
    • Jae-Chen Shin
    • Seon-Min Park
    • Kang Seok Seo
    • Ji-Young Choi
    • Jung-Il Chae
    • Jung-Hyun Shim
  • View Affiliations

  • Published online on: July 22, 2013     https://doi.org/10.3892/ijo.2013.2028
  • Pages: 1103-1110
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Honokiol (HK), a novel plant-derived natural product, is a physiologically activated compound with polyphenolic structure, and has been identified to function as an anticancer agent. It has been widely used in several diseases as a traditional medicine for a long time. We investigated whether HK could show anticancer effects on two oral squamous cell lines (OSCCs), HN-22 and HSC-4. We demonstrated that HK-treated cells showed dramatic reduction in cell growth and apoptotic cell morphologies. Intriguingly, the transcription factor specificity protein 1 (Sp1) was significantly inhibited by HK in a dose-dependent manner. Furthermore, we checked changes in cell cycle regulatory proteins and anti-apoptotic proteins at the molecular level, which are known as Sp1 target genes. The important key regulators in the cell cycle such as p27 and p21 were up-regulated by HK-mediated down-regulation of Sp1, whereas anti-apoptotic proteins including Mcl-1 and survivin were decreased, resulting in caspase-dependent apoptosis. Taken together, results from this study suggest that HK could modulate Sp1 transactivation and induce apoptotic cell death through the regulation of cell cycle and suppression of anti‑apoptotic proteins. In addition, HK may be used in cancer prevention and therapies to improve the clinical outcome as an anticancer drug.
View Figures
View References

Related Articles

Journal Cover

October 2013
Volume 43 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Kim D, Ko SM, Jeon Y, Noh Y, Choi N, Cho S, Moon HS, Cho YS, Shin J, Park S, Park S, et al: Anti-proliferative effect of honokiol in oral squamous cancer through the regulation of specificity protein 1. Int J Oncol 43: 1103-1110, 2013.
APA
Kim, D., Ko, S.M., Jeon, Y., Noh, Y., Choi, N., Cho, S. ... Shim, J. (2013). Anti-proliferative effect of honokiol in oral squamous cancer through the regulation of specificity protein 1. International Journal of Oncology, 43, 1103-1110. https://doi.org/10.3892/ijo.2013.2028
MLA
Kim, D., Ko, S. M., Jeon, Y., Noh, Y., Choi, N., Cho, S., Moon, H. S., Cho, Y. S., Shin, J., Park, S., Seo, K. S., Choi, J., Chae, J., Shim, J."Anti-proliferative effect of honokiol in oral squamous cancer through the regulation of specificity protein 1". International Journal of Oncology 43.4 (2013): 1103-1110.
Chicago
Kim, D., Ko, S. M., Jeon, Y., Noh, Y., Choi, N., Cho, S., Moon, H. S., Cho, Y. S., Shin, J., Park, S., Seo, K. S., Choi, J., Chae, J., Shim, J."Anti-proliferative effect of honokiol in oral squamous cancer through the regulation of specificity protein 1". International Journal of Oncology 43, no. 4 (2013): 1103-1110. https://doi.org/10.3892/ijo.2013.2028