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A dynamic interplay between alternative polyadenylation and microRNA regulation: Implications for cancer (Review)

  • Authors:
    • Jindan An
    • Xiaodong Zhu
    • Hongwei Wang
    • Xiudong Jin
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Cancer Prevention and Treatment of Heilongjiang Province, Mudanjiang Medical University, Mudanjiang, P.R. China, Department of Pathology, Mudanjiang Medical University, Mudanjiang, P.R. China
  • Pages: 995-1001
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    Published online on: August 1, 2013
       https://doi.org/10.3892/ijo.2013.2047
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Abstract

Alternative polyadenylation and microRNA regulation are both mechanisms of post-transcriptional regulation of gene expression. Alternative polyadenylation often results in mRNA isoforms with the same coding sequence but different lengths of 3' UTRs, while microRNAs regulate gene expression by binding to specific mRNA 3' UTRs. In this sense, different isoforms of an mRNA may be differentially regulated by microRNAs, sometimes resulting in cellular proliferation and this mechanism is being speculated on as a potential cause for cancer development.
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Copy and paste a formatted citation
Spandidos Publications style
An J, Zhu X, Wang H and Jin X: A dynamic interplay between alternative polyadenylation and microRNA regulation: Implications for cancer (Review). Int J Oncol 43: 995-1001, 2013.
APA
An, J., Zhu, X., Wang, H., & Jin, X. (2013). A dynamic interplay between alternative polyadenylation and microRNA regulation: Implications for cancer (Review). International Journal of Oncology, 43, 995-1001. https://doi.org/10.3892/ijo.2013.2047
MLA
An, J., Zhu, X., Wang, H., Jin, X."A dynamic interplay between alternative polyadenylation and microRNA regulation: Implications for cancer (Review)". International Journal of Oncology 43.4 (2013): 995-1001.
Chicago
An, J., Zhu, X., Wang, H., Jin, X."A dynamic interplay between alternative polyadenylation and microRNA regulation: Implications for cancer (Review)". International Journal of Oncology 43, no. 4 (2013): 995-1001. https://doi.org/10.3892/ijo.2013.2047
Copy and paste a formatted citation
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Spandidos Publications style
An J, Zhu X, Wang H and Jin X: A dynamic interplay between alternative polyadenylation and microRNA regulation: Implications for cancer (Review). Int J Oncol 43: 995-1001, 2013.
APA
An, J., Zhu, X., Wang, H., & Jin, X. (2013). A dynamic interplay between alternative polyadenylation and microRNA regulation: Implications for cancer (Review). International Journal of Oncology, 43, 995-1001. https://doi.org/10.3892/ijo.2013.2047
MLA
An, J., Zhu, X., Wang, H., Jin, X."A dynamic interplay between alternative polyadenylation and microRNA regulation: Implications for cancer (Review)". International Journal of Oncology 43.4 (2013): 995-1001.
Chicago
An, J., Zhu, X., Wang, H., Jin, X."A dynamic interplay between alternative polyadenylation and microRNA regulation: Implications for cancer (Review)". International Journal of Oncology 43, no. 4 (2013): 995-1001. https://doi.org/10.3892/ijo.2013.2047
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