Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
October 2013 Volume 43 Issue 4

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October 2013 Volume 43 Issue 4

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Apolipoprotein E gene polymorphism influences aggressive behavior in prostate cancer cells by deregulating cholesterol homeostasis

  • Authors:
    • Godwin O. Ifere
    • Renee Desmond
    • Wendy Demark-Wahnefried
    • Tim R. Nagy
  • View Affiliations / Copyright

    Affiliations: Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA, Division of Preventive Medicine, UAB, Birmingham, AL 35294, USA
    Copyright: © Ifere et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 1002-1010
    |
    Published online on: August 7, 2013
       https://doi.org/10.3892/ijo.2013.2057
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

High circulating cholesterol and its deregulated homeostasis may facilitate prostate cancer progression. Genetic polymorphism in Apolipoprotein (Apo) E, a key cholesterol regulatory protein may effect changes in systemic cholesterol levels. In this investigation, we determined whether variants of the Apo E gene can trigger defective intracellular cholesterol efflux, which could promote aggressive prostate cancer. ApoE genotypes of weakly (non-aggressive), moderate and highly tumorigenic (aggressive) prostate cancer cell lines were characterized, and we explored whether the ApoE variants were associated with tumor aggressiveness generated by intra­cellular cholesterol imbalance, using the expression of caveolin-1 (cav-1), a pro-malignancy surrogate of cholesterol overload. Restriction isotyping of ApoE isoforms revealed that the non-aggressive cell lines carried ApoE ε3/ε3 or ε3/ε4 alleles, while the aggressive cell lines carried the Apoε2/ε4 alleles. Our data suggest a contrast between the non-aggressive and the aggressive prostate cancer cell lines in the pattern of cholesterol efflux and cav-1 expression. Our exploratory results suggest a relationship between prostate aggressiveness, ApoE isoforms and cholesterol imbalance. Further investigation of this relationship may elucidate the molecular basis for considering cholesterol as a risk factor of aggressive prostate tumors, and underscore the potential of the dysfunctional ApoE2/E4 isoform as a biomarker of aggressive disease.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1. 

Williams SD, Cook ED, Anderson KB and Hamilton SJ: Bridging the gap between populations: the challenge of reducing cancer disparities among African-American and other ethnic minority populations. US Oncol. 4:72–75. 2008.

2. 

Ifere GO, Abebe F and Ananaba GA: Emergent trends in the reported incidence of prostate cancer in Nigeria. Clin Epidemiol. 4:19–32. 2012. View Article : Google Scholar : PubMed/NCBI

3. 

Sakr WA: Prostatic intraepithelial neoplasia: A marker for high-risk groups and a potential target for chemoprevention. Eur Urol. 35:474–478. 1999. View Article : Google Scholar : PubMed/NCBI

4. 

Bock CH, Powell I, Kittles RA, Hsing AW and Carpten J: Racial disparity in prostate cancer incidence, biochemical recurrence, and mortality. Prostate Cancer. 716178:1–2. 2011. View Article : Google Scholar : PubMed/NCBI

5. 

Bigler SA, Pound CR and Zhou X: A retrospective study on pathological features and racial disparities in prostate cancer. Prostate Cancer. 2011:2394602011. View Article : Google Scholar : PubMed/NCBI

6. 

Lee J, Demissie K, Lu SE and Rhoads GG: Cancer incidence among Korean-American immigrants in the United States and native Koreans of South Korea. Cancer Control. 14:78–85. 2007.PubMed/NCBI

7. 

Ma RW and Chapman K: A systematic review of the effect of diet in prostate cancer prevention and treatment. J Hum Nutr Diet. 22:187–199. 2009. View Article : Google Scholar : PubMed/NCBI

8. 

Michaud DS, Augustsson K, Rimm EB, Stampfer MJ, Willet WC and Giovanucci E: A prospective study on intake of animal products and risk of prostate cancer. Cancer Causes Control. 12:557–567. 2001. View Article : Google Scholar : PubMed/NCBI

9. 

Waddell WJ: Epidemiological studies and effects of environmental estrogens. Int J Toxicol. 17:173–191. 1998. View Article : Google Scholar

10. 

Le Marchand L and Wilkens LR: Design considerations for genomic association studies: importance of gene-environment interactions. Cancer Epidemiol Biomarkers Prev. 17:263–267. 2008.PubMed/NCBI

11. 

Nothlings U, Yamamoto JF, Wilkens LR, Murphy SP, Park SY, Henderson BE, Kolonel LN and Le Marchand L: Meat and heterocyclic amine intake, smoking, NAT1 and NAT2 polymorphisms, and colorectal cancer risk in the multiethnic cohort study. Cancer Epidemiol Biomarkers Prev. 18:2097–2106. 2009. View Article : Google Scholar : PubMed/NCBI

12. 

Wünsch Filho V and Zago MA: Modern cancer epidemiology research: genetic polymorphism and environment. Rev Saude Publica. 39:490–497. 2005.

13. 

Finch CE and Stanford CB: Meat-adaptive genes and the evolution of slower aging in humans. Q Rev Biol. 79:3–50. 2004. View Article : Google Scholar : PubMed/NCBI

14. 

Mahley RW: Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science. 240:622–630. 1988. View Article : Google Scholar : PubMed/NCBI

15. 

Tziakas DN, Chalikias GK, Antonoglou CO, Veletza S, Tentes IK, Kortsaris AX, Hatseras DI and Kaski JC: Apolipoprotein E genotype and circulating interleukin-10 levels in patients with stable and unstable coronary artery disease. J Am Coll Cardiol. 48:2471–2481. 2006. View Article : Google Scholar : PubMed/NCBI

16. 

Leduc V, Domenger D, De Beaumont L, Lalonde D, Bélanger-Jasmin S and Poirier J: Function and comorbidities of apolipoprotein E in Alzheimer’s disease. Int J Alzheimers Dis. 2011:1–22. 2011.

17. 

Eichner JE, Dunn ST, Perveen G, Thompson DM, Stewart KE and Stroehla BC: Apolipoprotein E polymorphism and cardiovascular disease: a HuGE review. Am J Epidemiol. 155:487–495. 2002. View Article : Google Scholar : PubMed/NCBI

18. 

Mahley RW and Rall SC Jr: Apolipoprotein E: far more than a lipid transport protein. Annu Rev Genomics Hum Genet. 1:507–537. 2000. View Article : Google Scholar : PubMed/NCBI

19. 

Moore RJ, Chamberlain RM and Khuri FR: Apolipoprotein E and the risk of breast cancer in African-American and non-Hispanic white women. A review. Oncology. 66:79–93. 2004. View Article : Google Scholar : PubMed/NCBI

20. 

Kallio MJ, Salmenperä L, Siimes MA, Perheentupa J, Gylling H and Miettinen TA: Apolipoprotein E phenotype determines serum cholesterol in infants during both high-cholesterol breast feeding and low-cholesterol formula feeding. J Lipid Res. 38:759–764. 1997.PubMed/NCBI

21. 

Berglund L: The APOE gene and diets - food (and drink) for thought. Am J Clin Nutr. 73:669–670. 2001.PubMed/NCBI

22. 

Papaioannou I, Simmons JP and Owen JS: Targeted in situ gene correction of dysfunctional APOE alleles to produce atheroprotective plasma ApoE3 protein. Cardiol Res Pract. 2012:1487962012.PubMed/NCBI

23. 

Kockx M, Jessup W and Kritharides L: Regulation of endogenous apolipoprotein E secretion by macrophages. Arterioscler Thromb Vasc Biol. 28:1060–1067. 2008. View Article : Google Scholar : PubMed/NCBI

24. 

Huang ZH, Fitzgerald ML and Mazzone T: Distinct cellular loci for the ABCA1-dependent and ABCA1-independent lipid efflux mediated by endogenous apolipoprotein E expression. Arterioscler Thromb Vasc Biol. 26:157–162. 2006. View Article : Google Scholar : PubMed/NCBI

25. 

Huang Y, von Eckardstein A, Wu S and Assmann G: Effects of the apolipoprotein E polymorphism on uptake and transfer of cell derived cholesterol in plasma. J Clin Invest. 96:2693–2701. 1995. View Article : Google Scholar : PubMed/NCBI

26. 

Lane RM and Farlow MR: Lipid homeostasis and apolipoprotein E in the development and progression of Alzheimer’s disease. J Lipid Res. 46:949–968. 2005.

27. 

Uittenbogaard A, Ying Y and Smart EJ: Characterization of a cytosolic heat-shock protein-caveolin chaperone complex. Involvement in cholesterol trafficking. J Biol Chem. 273:6525–6532. 1998. View Article : Google Scholar : PubMed/NCBI

28. 

Liscum L and Munn NJ: Intracellular cholesterol transport. Biochim Biophys Acta. 1438:19–37. 1999. View Article : Google Scholar

29. 

Li YC, Park MJ, Ye SK, Kim CW and Kim YN: Elevated levels of cholesterol-rich lipid rafts in cancer cells are correlated with apoptosis sensitivity induced by cholesterol-depleting agents. Am J Pathol. 168:1107–1118. 2006. View Article : Google Scholar : PubMed/NCBI

30. 

Hixson JE and Vernier DT: Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with Hha I. J Lipid Res. 31:545–548. 1990.PubMed/NCBI

31. 

Sankaranarayanan S, Kellner-Weibel G, de la Llera-Moya M, Phillips MC, Asztalos BF, Bittmam R and Rothblat GH: A sensitive assay for ABCA1-mediated cholesterol efflux using BODIPY-cholesterol. J Lipid Res. 52:2332–2340. 2011. View Article : Google Scholar : PubMed/NCBI

32. 

Yue L and Mazzone T: Endogenous adipocyte apolipoprotein E is colocalized with caveolin at the adipocyte plasma membrane. J Lipid Res. 52:489–498. 2011. View Article : Google Scholar : PubMed/NCBI

33. 

Nair HK, Rao KV, Aalinkeel R, Mahajan S, Chawda R and Schwartz SA: Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. Clin Diagn Lab Immunol. 11:63–69. 2004.PubMed/NCBI

34. 

Saraon P, Musrap N, Cretu D, Karagiannis GS, Batruch I, Smith C, Drabovich AP, Trudel D, van der Kwast T, Morrissey C, Jarvi KA and Diamandis EP: Proteomic profiling of androgen-independent prostate cancer cell lines reveals a role for protein S during the development of high grade and castration-resistant prostate cancer. J Biol Chem. 287:34019–34031. 2012. View Article : Google Scholar

35. 

Wang B, Yang Q, Ceniccola K, Bianco F, Andrawis R, Jarret T, Frazier H, Patierno SR and Lee NH: Androgen receptor-target gene in African American prostate cancer disparities. Prostate Cancer. 2013:7635692013. View Article : Google Scholar : PubMed/NCBI

36. 

Kim DH and Wirtz D: Recapitulating cancer cell invasion in vitro. Proc Natl Acad Sci USA. 108:6693–6694. 2011. View Article : Google Scholar : PubMed/NCBI

37. 

Hoosein NM: Neuroendocrine and immune mediators in prostate cancer progression. Front Biosci. 3:D1274–D1279. 1998.PubMed/NCBI

38. 

Hara T, Miyazaki H, Lee A, Tran CP and Reiter RE: Androgen receptor and invasion in prostate cancer. Cancer Res. 68:1128–1135. 2008. View Article : Google Scholar : PubMed/NCBI

39. 

Nomura DK, Lombardi DP, Chang JW, Niessen S, Ward AM, Long JZ, Hoover HH and Cravatt BF: Monoacylglycerol lipase exerts dual control over endocannabinoid and fatty acid pathways to support prostate cancer. Chem Biol. 18:846–856. 2011. View Article : Google Scholar : PubMed/NCBI

40. 

Venanzoni MC, Giunta S, Murara GB, Storari L, Crescini C, Mazzucchelli R, Montironi R and Seth A: Apolipoprotein E expression in localized prostate cancers. Int J Oncol. 22:779–786. 2003.PubMed/NCBI

41. 

Saadat M: Apolipoprotein E (ApoE) polymorphism and susceptibility to breast cancer: a meta-analysis. Cancer Res Treat. 44:121–126. 2012. View Article : Google Scholar : PubMed/NCBI

42. 

Niemi M, Kervinen K, Kiviniemi H, Lukkarinen O, Kyllönen AP, Apaja-Sarkkinen M, Savolainen MJ, Kairaluoma MI and Kesäniemi YA: Apolipoprotein E phenotype, cholesterol and breast and prostate cancer. J Epidemiol Community Health. 54:938–939. 2000. View Article : Google Scholar : PubMed/NCBI

43. 

Haapla K, Lehtimäki T, Ilveskoski E and Koivisto PA: Apolipoprotein E is not linked to locally recurrent hormone-refractory prostate cancer. Prostate Cancer Prostatic Dis. 3:107–109. 2000. View Article : Google Scholar : PubMed/NCBI

44. 

Koivisto P, Visakorpi T, Rantala I and Isola J: Increased cell proliferation activity and decreased cell death are associated with the emergence of hormone-refractory recurrent prostate cancer. J Pathol. 183:51–56. 1997. View Article : Google Scholar : PubMed/NCBI

45. 

Mostaghel EA, Solomon KR, Pelton K, Freeman MR and Montgomery RB: Impact of circulating cholesterol levels on growth and intratumoral androgen concentration of prostate tumors. PLoS One. 7:e300622012. View Article : Google Scholar : PubMed/NCBI

46. 

Krimbou L, Denis M, Haidar B, Carrier M, Marci M and Genest J Jr: Molecular interactions between apoE and ABCA1: impact on apoE lipidation. J Lipid Res. 45:839–848. 2004. View Article : Google Scholar : PubMed/NCBI

47. 

Cullen P, Cignarella A, Brennhausen B, Mohr S, Assmann G and Von Eckardstein A: Phenotype-dependent differences in apolipoprotein E metabolism and in cholesterol homeostasis in human monocyte-derived macrophages. J Clin Invest. 101:1670–1677. 1998. View Article : Google Scholar : PubMed/NCBI

48. 

Murtola TJ, Syvälä H, Pennanen P, Bläuer M, Solakivi T, Ylikomi T and Tammela TL: The importance of LDL and cholesterol metabolism for prostate epithelial cell growth. PLoS One. 7:e394452012. View Article : Google Scholar : PubMed/NCBI

49. 

Smith JD, Miyata M, Ginsberg M, Grigaux C, Shmookler E and Plump AS: Cyclic AMP induces apolipoprotein E binding activity and promotes cholesterol efflux from a macrophage cell line to apolipoprotein acceptors. J Biol Chem. 271:30647–30655. 1996. View Article : Google Scholar : PubMed/NCBI

50. 

Hara M, Matsushima T, Satoh H, Iso-o N, Noto H, Togo M, Kimura S, Hashimoto Y and Tsukamoto K: Isoform-dependent cholesterol efflux from macrophages by apolipoprotein E is modulated by cell surface proteoglycan. Arterioscler Thromb Vasc Biol. 23:269–274. 2003. View Article : Google Scholar : PubMed/NCBI

51. 

Karasinska JM and Hayden MR: Cholesterol metabolism in Huntington disease. Nat Rev Neurol. 7:561–572. 2011. View Article : Google Scholar : PubMed/NCBI

52. 

Fernández-Hernando C, Yu J, Dávalos A, Prendergast J and Sessa WC: Endothelial-specific overexpression of caveolin-1 accelerates atherosclerosis in apolipoprotein E-deficient mice. Am J Pathol. 177:998–1003. 2010.PubMed/NCBI

53. 

Cohen AW, Hnaska R, Schubert W and Lisanti MP: Role of caveolae and caveolins in health and disease. Physiol Rev. 84:1341–1379. 2004. View Article : Google Scholar : PubMed/NCBI

54. 

Frank PG, Cheung MW, Pavlides S, Llaverias G, Park DS and Lisanti MP: Caveolin-1 and regulation of cellular cholesterol homeostasis. Am J Physiol Heart Circ Physiol. 291:H677–H686. 2006. View Article : Google Scholar : PubMed/NCBI

55. 

Daniel EE, El-Yazbi A and Cho WJ: Caveolae and calcium handling, a review and a hypothesis. J Cell Mol Med. 10:529–544. 2006. View Article : Google Scholar : PubMed/NCBI

56. 

Yang G, Truong LD, Wheeler TM and Thompson TC: Caveolin-1 expression in clinically confined human prostate cancer: a novel prognostic marker. Cancer Res. 59:5719–5723. 1999.PubMed/NCBI

57. 

Thompson TC: Metastasis-related genes in prostate cancer: the role of caveolin-1. Cancer Metastasis Rev. 17:439–442. 1999. View Article : Google Scholar : PubMed/NCBI

58. 

Williams TM, Hassan GS, Li J, Cohen AW, Medina F, Frank PG, Pestell RG, Di Vizio D, Loda M and Lisanti MP: Caveolin-1 promotes tumor progression in an autochthonous mouse model of prostate cancer. J Biol Chem. 280:25134–25145. 2005. View Article : Google Scholar : PubMed/NCBI

59. 

Lin YC, Ma C, Hsu WC, Lo HF and Yang VC: Molecular interaction between caveolin-1 and ABCA1 on high-density lipoprotein-mediated cholesterol efflux in aortic endothelial cells. Cardiovasc Res. 75:575–583. 2007. View Article : Google Scholar

60. 

Le Lay S, Rodriguez M, Jessup W, Rentero C, Li Q, Cartland S, Grewal T and Gaus K: Caveolin-1-mediated apolipoprotein A-I membrane binding sites are not required for cholesterol efflux. PLoS One. 6:e233532011.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ifere GO, Desmond R, Demark-Wahnefried W and Nagy TR: Apolipoprotein E gene polymorphism influences aggressive behavior in prostate cancer cells by deregulating cholesterol homeostasis. Int J Oncol 43: 1002-1010, 2013.
APA
Ifere, G.O., Desmond, R., Demark-Wahnefried, W., & Nagy, T.R. (2013). Apolipoprotein E gene polymorphism influences aggressive behavior in prostate cancer cells by deregulating cholesterol homeostasis. International Journal of Oncology, 43, 1002-1010. https://doi.org/10.3892/ijo.2013.2057
MLA
Ifere, G. O., Desmond, R., Demark-Wahnefried, W., Nagy, T. R."Apolipoprotein E gene polymorphism influences aggressive behavior in prostate cancer cells by deregulating cholesterol homeostasis". International Journal of Oncology 43.4 (2013): 1002-1010.
Chicago
Ifere, G. O., Desmond, R., Demark-Wahnefried, W., Nagy, T. R."Apolipoprotein E gene polymorphism influences aggressive behavior in prostate cancer cells by deregulating cholesterol homeostasis". International Journal of Oncology 43, no. 4 (2013): 1002-1010. https://doi.org/10.3892/ijo.2013.2057
Copy and paste a formatted citation
x
Spandidos Publications style
Ifere GO, Desmond R, Demark-Wahnefried W and Nagy TR: Apolipoprotein E gene polymorphism influences aggressive behavior in prostate cancer cells by deregulating cholesterol homeostasis. Int J Oncol 43: 1002-1010, 2013.
APA
Ifere, G.O., Desmond, R., Demark-Wahnefried, W., & Nagy, T.R. (2013). Apolipoprotein E gene polymorphism influences aggressive behavior in prostate cancer cells by deregulating cholesterol homeostasis. International Journal of Oncology, 43, 1002-1010. https://doi.org/10.3892/ijo.2013.2057
MLA
Ifere, G. O., Desmond, R., Demark-Wahnefried, W., Nagy, T. R."Apolipoprotein E gene polymorphism influences aggressive behavior in prostate cancer cells by deregulating cholesterol homeostasis". International Journal of Oncology 43.4 (2013): 1002-1010.
Chicago
Ifere, G. O., Desmond, R., Demark-Wahnefried, W., Nagy, T. R."Apolipoprotein E gene polymorphism influences aggressive behavior in prostate cancer cells by deregulating cholesterol homeostasis". International Journal of Oncology 43, no. 4 (2013): 1002-1010. https://doi.org/10.3892/ijo.2013.2057
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team