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Article

Oncogenic function of p34SEI-1 via NEDD4‑1‑mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway

  • Authors:
    • Samil Jung
    • Chengping Li
    • Dongjun Jeong
    • Soonduck Lee
    • Jiyeon Ohk
    • Meeyoung Park
    • Songyi Han
    • Jingjing Duan
    • Changjin Kim
    • Young Yang
    • Keun-Il Kim
    • Jong-Seok Lim
    • Young-Sook Kang
    • Myeong-Sok Lee
  • View Affiliations / Copyright

    Affiliations: Department of Biological Science and Research Center for Women's Diseases, Sookmyung Women's University, Seoul 140-742, Republic of Korea, Department of Pathology, College of Medicine, Soonchunhyang University, Chonan 330-090, Republic of Korea, College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Republic of Korea
  • Pages: 1587-1595
    |
    Published online on: August 20, 2013
       https://doi.org/10.3892/ijo.2013.2064
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Abstract

A 34-KD protein encoded by the SEI-1 gene (p34SEI‑1), is a relatively recently discovered oncoprotein that has multiple important biological functions. Our data show that p34SEI-1 enhances cancer cell survival and promotes tumorigenesis by downregulating the tumor suppressor PTEN, a negative regulator of the PI3K/AKT signaling pathway, and therefore activating the PI3K/AKT signaling pathway. In this process, p34SEI-1 positively affects NEDD4-1 gene expression both at the transcriptional and protein levels. Furthermore, the expression levels of p34SEI-1 and NEDD4-1 were found to be coordinated in tumor tissues obtained from patients with breast cancer. We also show that p34SEI-1 affects the subcellular localization of PTEN.
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Copy and paste a formatted citation
Spandidos Publications style
Jung S, Li C, Jeong D, Lee S, Ohk J, Park M, Han S, Duan J, Kim C, Yang Y, Yang Y, et al: Oncogenic function of p34SEI-1 via NEDD4‑1‑mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway. Int J Oncol 43: 1587-1595, 2013.
APA
Jung, S., Li, C., Jeong, D., Lee, S., Ohk, J., Park, M. ... Lee, M. (2013). Oncogenic function of p34SEI-1 via NEDD4‑1‑mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway. International Journal of Oncology, 43, 1587-1595. https://doi.org/10.3892/ijo.2013.2064
MLA
Jung, S., Li, C., Jeong, D., Lee, S., Ohk, J., Park, M., Han, S., Duan, J., Kim, C., Yang, Y., Kim, K., Lim, J., Kang, Y., Lee, M."Oncogenic function of p34SEI-1 via NEDD4‑1‑mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway". International Journal of Oncology 43.5 (2013): 1587-1595.
Chicago
Jung, S., Li, C., Jeong, D., Lee, S., Ohk, J., Park, M., Han, S., Duan, J., Kim, C., Yang, Y., Kim, K., Lim, J., Kang, Y., Lee, M."Oncogenic function of p34SEI-1 via NEDD4‑1‑mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway". International Journal of Oncology 43, no. 5 (2013): 1587-1595. https://doi.org/10.3892/ijo.2013.2064
Copy and paste a formatted citation
x
Spandidos Publications style
Jung S, Li C, Jeong D, Lee S, Ohk J, Park M, Han S, Duan J, Kim C, Yang Y, Yang Y, et al: Oncogenic function of p34SEI-1 via NEDD4‑1‑mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway. Int J Oncol 43: 1587-1595, 2013.
APA
Jung, S., Li, C., Jeong, D., Lee, S., Ohk, J., Park, M. ... Lee, M. (2013). Oncogenic function of p34SEI-1 via NEDD4‑1‑mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway. International Journal of Oncology, 43, 1587-1595. https://doi.org/10.3892/ijo.2013.2064
MLA
Jung, S., Li, C., Jeong, D., Lee, S., Ohk, J., Park, M., Han, S., Duan, J., Kim, C., Yang, Y., Kim, K., Lim, J., Kang, Y., Lee, M."Oncogenic function of p34SEI-1 via NEDD4‑1‑mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway". International Journal of Oncology 43.5 (2013): 1587-1595.
Chicago
Jung, S., Li, C., Jeong, D., Lee, S., Ohk, J., Park, M., Han, S., Duan, J., Kim, C., Yang, Y., Kim, K., Lim, J., Kang, Y., Lee, M."Oncogenic function of p34SEI-1 via NEDD4‑1‑mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway". International Journal of Oncology 43, no. 5 (2013): 1587-1595. https://doi.org/10.3892/ijo.2013.2064
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