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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2013 Volume 43 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model

  • Authors:
    • Ming-Szu Hung
    • Zhidong Xu
    • Yu Chen
    • Emmanuel Smith
    • Jian-Hua Mao
    • David Hsieh
    • Yu-Ching Lin
    • Cheng-Ta Yang
    • David M. Jablons
    • Liang You
  • View Affiliations / Copyright

    Affiliations: Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA, Department of Molecular Medicine, College of Medicine, University of South Florida, Tampa, FL, USA, Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA, USA, Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Chiayi branch, Taoyuan, Taiwan, R.O.C., Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Taoyuan branch, Taoyuan, Taiwan, R.O.C.
  • Pages: 1517-1522
    |
    Published online on: September 4, 2013
       https://doi.org/10.3892/ijo.2013.2087
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Abstract

Casein kinase II (CK2) inhibitors suppress cancer cell growth. In this study, we examined the inhibitory effects of a novel CK2 inhibitor, hematein, on tumor growth in a murine xenograft model. We found that in lung cancer cells, hematein inhibited cancer cell growth, Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increased apoptosis. In a murine xenograft model of lung cancer, hematein inhibited tumor growth without significant toxicity to the mice tested. Molecular docking showed that hematein binds to CK2α in durable binding sites. Collectively, our results suggest that hematein is an allosteric inhibitor of protein kinase CK2 and has antitumor activity to lung cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Hung M, Xu Z, Chen Y, Smith E, Mao J, Hsieh D, Lin Y, Yang C, Jablons DM, You L, You L, et al: Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model. Int J Oncol 43: 1517-1522, 2013.
APA
Hung, M., Xu, Z., Chen, Y., Smith, E., Mao, J., Hsieh, D. ... You, L. (2013). Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model. International Journal of Oncology, 43, 1517-1522. https://doi.org/10.3892/ijo.2013.2087
MLA
Hung, M., Xu, Z., Chen, Y., Smith, E., Mao, J., Hsieh, D., Lin, Y., Yang, C., Jablons, D. M., You, L."Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model". International Journal of Oncology 43.5 (2013): 1517-1522.
Chicago
Hung, M., Xu, Z., Chen, Y., Smith, E., Mao, J., Hsieh, D., Lin, Y., Yang, C., Jablons, D. M., You, L."Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model". International Journal of Oncology 43, no. 5 (2013): 1517-1522. https://doi.org/10.3892/ijo.2013.2087
Copy and paste a formatted citation
x
Spandidos Publications style
Hung M, Xu Z, Chen Y, Smith E, Mao J, Hsieh D, Lin Y, Yang C, Jablons DM, You L, You L, et al: Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model. Int J Oncol 43: 1517-1522, 2013.
APA
Hung, M., Xu, Z., Chen, Y., Smith, E., Mao, J., Hsieh, D. ... You, L. (2013). Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model. International Journal of Oncology, 43, 1517-1522. https://doi.org/10.3892/ijo.2013.2087
MLA
Hung, M., Xu, Z., Chen, Y., Smith, E., Mao, J., Hsieh, D., Lin, Y., Yang, C., Jablons, D. M., You, L."Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model". International Journal of Oncology 43.5 (2013): 1517-1522.
Chicago
Hung, M., Xu, Z., Chen, Y., Smith, E., Mao, J., Hsieh, D., Lin, Y., Yang, C., Jablons, D. M., You, L."Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model". International Journal of Oncology 43, no. 5 (2013): 1517-1522. https://doi.org/10.3892/ijo.2013.2087
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