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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2013 Volume 43 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Article

Integrin alpha 6: A novel therapeutic target in esophageal squamous cell carcinoma

  • Authors:
    • Junhye Kwon
    • Tae-Sup Lee
    • Hae Won Lee
    • Moon Chul Kang
    • Hyeon-Joon Yoon
    • Ji-Hee Kim
    • Jong Ho Park
  • View Affiliations / Copyright

    Affiliations: Department of Translational Research, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea, Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea, Department of Thoracic Surgery, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea
  • Pages: 1523-1530
    |
    Published online on: September 13, 2013
       https://doi.org/10.3892/ijo.2013.2097
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Abstract

Esophageal squamous cell carcinoma (ESCC), the most common subtype of esophageal cancer in East Asian countries, is a devastating disease characterized by distinctly high incidence and mortality rates. Our previous expression profile analysis showed that integrin alpha 6 (ITGA6) is highly expressed in ESCC tissues. To validate cell surface expression of ITGA6 as a novel target in ESCC, we investigated ITGA6 expression in tumor tissue samples and cell lines of ESCC and found that ITGA6 was upregulated in these cells. In vitro knockdown of ITGA6 in ESCC cells resulted in inhibition of cell proliferation, invasion and colony formation. In addition, we demonstrated that ITGA6 associates with integrin beta 4 (ITGB4), and that this heterodimer complex is upregulated in both ESCC tissues and cell lines. Moreover, our biodistribution results in an ESCC xenograft model indicated that ITGA6 is a possible target for antibody-related diagnostic and therapeutic modalities in ESCC. Thus, our findings suggest that ITGA6 plays an important role in tumorigenesis in ESCC and represents a potential therapeutic target in the treatment of ESCC.
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Copy and paste a formatted citation
Spandidos Publications style
Kwon J, Lee T, Lee HW, Kang MC, Yoon H, Kim J and Park JH: Integrin alpha 6: A novel therapeutic target in esophageal squamous cell carcinoma. Int J Oncol 43: 1523-1530, 2013.
APA
Kwon, J., Lee, T., Lee, H.W., Kang, M.C., Yoon, H., Kim, J., & Park, J.H. (2013). Integrin alpha 6: A novel therapeutic target in esophageal squamous cell carcinoma. International Journal of Oncology, 43, 1523-1530. https://doi.org/10.3892/ijo.2013.2097
MLA
Kwon, J., Lee, T., Lee, H. W., Kang, M. C., Yoon, H., Kim, J., Park, J. H."Integrin alpha 6: A novel therapeutic target in esophageal squamous cell carcinoma". International Journal of Oncology 43.5 (2013): 1523-1530.
Chicago
Kwon, J., Lee, T., Lee, H. W., Kang, M. C., Yoon, H., Kim, J., Park, J. H."Integrin alpha 6: A novel therapeutic target in esophageal squamous cell carcinoma". International Journal of Oncology 43, no. 5 (2013): 1523-1530. https://doi.org/10.3892/ijo.2013.2097
Copy and paste a formatted citation
x
Spandidos Publications style
Kwon J, Lee T, Lee HW, Kang MC, Yoon H, Kim J and Park JH: Integrin alpha 6: A novel therapeutic target in esophageal squamous cell carcinoma. Int J Oncol 43: 1523-1530, 2013.
APA
Kwon, J., Lee, T., Lee, H.W., Kang, M.C., Yoon, H., Kim, J., & Park, J.H. (2013). Integrin alpha 6: A novel therapeutic target in esophageal squamous cell carcinoma. International Journal of Oncology, 43, 1523-1530. https://doi.org/10.3892/ijo.2013.2097
MLA
Kwon, J., Lee, T., Lee, H. W., Kang, M. C., Yoon, H., Kim, J., Park, J. H."Integrin alpha 6: A novel therapeutic target in esophageal squamous cell carcinoma". International Journal of Oncology 43.5 (2013): 1523-1530.
Chicago
Kwon, J., Lee, T., Lee, H. W., Kang, M. C., Yoon, H., Kim, J., Park, J. H."Integrin alpha 6: A novel therapeutic target in esophageal squamous cell carcinoma". International Journal of Oncology 43, no. 5 (2013): 1523-1530. https://doi.org/10.3892/ijo.2013.2097
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