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Article

Oleifolioside B-mediated autophagy promotes apoptosis in A549 human non-small cell lung cancer cells

  • Authors:
    • Cheng-Yun Jin
    • Hai Yang Yu
    • Cheol Park
    • Min Ho Han
    • Su Hyun Hong
    • Kyoung-Sook Kim
    • Young-Choon Lee
    • Young-Chae Chang
    • Jaehun Cheong
    • Sung-Kwon Moon
    • Gi-Young Kim
    • Hyung-In Moon
    • Wun-Jae Kim
    • Jai-Heon Lee
    • Yung Hyun Choi
  • View Affiliations / Copyright

    Affiliations: School of Pharmaceutical Science, Zhengzhou University, Henan 450001, P.R. China., College of Natural Resources and Life Science, BK21 Center for Silver-Bio Industrialization, Dong-A University, Busan 604-714, Republic of Korea, Department of Molecular Biology, College of Natural Sciences, Dongeui University, Busan 614-714, Republic of Korea, Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan 614-052, Republic of Korea, Research Institute of Biomedical Engineering and Department of Medicine, Catholic University of Daegu School of Medicine, Daegu 705-718, Republic of Korea, Department of Molecular Biology, College of Natural Sciences, Busan National University, Busan 609-735, Republic of Korea, School of Food Science and Technology, Chung-Ang University, Ansung 456-756, Republic of Korea, Laboratory of Immunobiology, Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea, Department of Urology, Chungbuk National University College of Medicine, Cheongju 361-763, Republic of Korea
  • Pages: 1943-1950
    |
    Published online on: October 17, 2013
       https://doi.org/10.3892/ijo.2013.2143
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Abstract

The biochemical mechanisms of cell death by oleifolioside B (OB), a cycloartane-type triterpene glycoside isolated from Dendropanax morbifera Leveille, were investigated in A549 human lung carcinoma cells. Our data indicated that exposure to OB led to caspase activation and typical features of apoptosis; however, apoptotic cell death was not prevented by z-VAD-fmk, a pan-caspase inhibitor, demonstrating that OB-induced apoptosis was independent of caspase activation. Subsequently, we found that OB increased autophagy, as indicated by an increase in monodansylcadaverine fluorescent dye-labeled autophagosome formation and in the levels of the autophagic form of microtubule-associated protein 1 light chain 3 and Atg3, an autophagy-specific gene, which is associated with inhibiting phospho-nuclear factor erythroid 2-related factor 2 (Nrf2) expression. However, pretreatment with bafilomycin A1, an autophagy inhibitor, attenuated OB-induced apoptosis and dephosphorylation of Nrf2. The data suggest that OB-induced autophagy functions as a death mechanism in A549 cells and OB has potential as a novel anticancer agent capable of targeting apoptotic and autophagic cell death and the Nrf2 signaling pathway.
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1. 

Corcelle EA, Puustinen P and Jäättelä M: Apoptosis and autophagy: Targeting autophagy signalling in cancer cells - ‘trick or treats’? FEBS J. 276:6084–6096. 2009.

2. 

Levine B: Cell biology: autophagy and cancer. Nature. 446:745–747. 2007. View Article : Google Scholar : PubMed/NCBI

3. 

Fuchs Y and Steller H: Programmed cell death in animal development and disease. Cell. 147:742–758. 2011. View Article : Google Scholar : PubMed/NCBI

4. 

Hengartner MO: The biochemistry of apoptosis. Nature. 407:770–776. 2000. View Article : Google Scholar : PubMed/NCBI

5. 

Okada H and Mak TW: Pathways of apoptotic and non-apoptotic death in tumour cells. Nat Rev Cancer. 4:592–603. 2004. View Article : Google Scholar : PubMed/NCBI

6. 

Jin Z and El-Deiry WS: Overview of cell death signaling pathways. Cancer Biol Ther. 4:139–163. 2005.

7. 

Klionsky DJ and Emr SD: Autophagy as a regulated pathway of cellular degradation. Science. 290:1717–1721. 2000. View Article : Google Scholar : PubMed/NCBI

8. 

Gozuacik D and Kimchi A: Autophagy and cell death. Curr Top Dev Biol. 78:217–245. 2007. View Article : Google Scholar

9. 

Mizushima N, Levine B, Cuervo AM and Klionsky DJ: Autophagy fights disease through cellular self-digestion. Nature. 451:1069–1075. 2008. View Article : Google Scholar : PubMed/NCBI

10. 

Cheng Y, Qiu F, Ye YC, Guo ZM, Tashiro S, Onodera S and Ikejima T: Autophagy inhibits reactive oxygen species-mediated apoptosis via activating p38-nuclear factor-kappa B survival pathways in oridonin-treated murine fibrosarcoma L929 cells. FEBS J. 276:1291–1306. 2009. View Article : Google Scholar

11. 

Eisenberg-Lerner A, Bialik S, Simon HU and Kimchi A: Life and death partners: apoptosis, autophagy and the cross-talk between them. Cell Death Differ. 16:966–975. 2009. View Article : Google Scholar : PubMed/NCBI

12. 

Jemal A, Siegel R, Xu J and Ward E: Cancer statistics, 2010. CA Cancer J Clin. 60:277–300. 2010. View Article : Google Scholar

13. 

Gridelli C, Maione P, Ferrara ML and Rossi A: Cetuximab and other anti-epidermal growth factor receptor monoclonal antibodies in the treatment of non-small cell lung cancer. Oncologist. 14:601–611. 2009. View Article : Google Scholar : PubMed/NCBI

14. 

Kapp FG, Sommer A, Kiefer T, Dölken G and Haendler B: 5-alpha-reductase type I (SRD5A1) is up-regulated in non-small cell lung cancer but does not impact proliferation, cell cycle distribution or apoptosis. Cancer Cell Int. 12:12012. View Article : Google Scholar : PubMed/NCBI

15. 

Park BY, Min BS, Oh SR, Kim JH, Kim TJ, Kim DH, Bae KH and Lee HK: Isolation and anticomplement activity of compounds from Dendropanax morbifera. J Ethnopharmacol. 90:403–408. 2004. View Article : Google Scholar : PubMed/NCBI

16. 

Chung IM, Kim MY, Park WH and Moon HI: Antiatherogenic activity of Dendropanax morbifera essential oil in rats. Pharmazie. 64:547–549. 2009.

17. 

Moon HI: Antidiabetic effects of dendropanoxide from leaves of Dendropanax morbifera Leveille in normal and streptozotocin-induced diabetic rats. Hum Exp Toxicol. 30:870–875. 2011. View Article : Google Scholar

18. 

Chung IM, Kim MY, Park SD, Park WH and Moon HI: In vitro evaluation of the antiplasmodial activity of Dendropanax morbifera against chloroquine-sensitive strains of Plasmodium falciparum. Phytother Res. 23:1634–1637. 2009.PubMed/NCBI

19. 

Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y and Yoshimori T: LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 19:5720–5728. 2000. View Article : Google Scholar : PubMed/NCBI

20. 

Riccioni R, Pasquini L, Mariani G, Saulle E, Rossini A, Diverio D, Pelosi E, Vitale A, Chierichini A, Cedrone M, Foà R, Lo Coco F, Peschle C and Testa U: TRAIL decoy receptors mediate resistance of acute myeloid leukemia cells to TRAIL. Haematologica. 90:612–624. 2005.PubMed/NCBI

21. 

Lee EW, Seo J, Jeong M, Lee S and Song J: The roles of FADD in extrinsic apoptosis and necroptosis. BMB Rep. 45:496–508. 2012. View Article : Google Scholar : PubMed/NCBI

22. 

Deveraux QL and Reed JC: IAP family proteins-suppressors of apoptosis. Genes Dev. 13:239–252. 1999. View Article : Google Scholar : PubMed/NCBI

23. 

Kroemer G and Reed JC: Mitochondrial control of cell death. Nat Med. 6:513–519. 2000. View Article : Google Scholar

24. 

Constantinou C, Papas KA and Constantinou AI: Caspase-independent pathways of programmed cell death: the unraveling of new targets of cancer therapy? Curr Cancer Drug Targets. 9:717–728. 2009. View Article : Google Scholar : PubMed/NCBI

25. 

Wu XX and Kakehi Y: Enhancement of lexatumumab-induced apoptosis in human solid cancer cells by cisplatin in caspase-dependent manner. Clin Cancer Res. 15:2039–2047. 2009. View Article : Google Scholar : PubMed/NCBI

26. 

Takeda S, Matsuo K, Yaji K, Okajima-Miyazaki S, Harada M, Miyoshi H, Okamoto Y, Amamoto T, Shindo M, Omiecinski CJ and Aramaki H: (-)-Xanthatin selectively induces GADD45γ and stimulates caspase-independent cell death in human breast cancer MDA-MB-231 cells. Chem Res Toxicol. 24:855–865. 2011.PubMed/NCBI

27. 

Bröker LE, Kruyt FA and Giaccone G: Cell death independent of caspases: a review. Clin Cancer Res. 11:3155–3162. 2005.

28. 

Pattingre S, Espert L, Biard-Piechaczyk M and Codogno P: Regulation of macroautophagy by mTOR and Beclin 1 complexes. Biochimie. 90:313–323. 2008. View Article : Google Scholar : PubMed/NCBI

29. 

Marquez RT and Xu L: Bcl-2: Beclin 1 complex: multiple, mechanisms regulating autophagy/apoptosis toggle switch. Am J Cancer Res. 2:214–221. 2012.PubMed/NCBI

30. 

Kang KW, Lee SJ and Kim SG: Molecular mechanism of nrf2 activation by oxidative stress. Antioxid Redox Signal. 7:1664–1673. 2005. View Article : Google Scholar : PubMed/NCBI

31. 

Khan NM, Sandur SK, Checker R, Sharma D, Poduval TB and Sainis KB: Pro-oxidants ameliorate radiation-induced apoptosis through activation of the calcium-ERK1/2-Nrf2 pathway. Free Radic Biol Med. 51:115–128. 2011. View Article : Google Scholar

32. 

Ansari N, Khodagholi F and Amini M: 2-Ethoxy-4,5-diphenyl-1,3-oxazine-6- one activates the Nrf2/HO-1 axis and protects against oxidative stress-induced neuronal death. Eur J Pharmacol. 658:84–90. 2011. View Article : Google Scholar : PubMed/NCBI

33. 

Choi KS: Autophagy and cancer. Exp Mol Med. 44:109–120. 2012. View Article : Google Scholar

34. 

Singh P, Godbole M, Rao G, Annarao S, Mitra K, Roy R, Ingle A, Agarwal G and Tiwari S: Inhibition of autophagy stimulates molecular iodine-induced apoptosis in hormone independent breast tumors. Biochem Biophys Res Commun. 415:181–186. 2011. View Article : Google Scholar : PubMed/NCBI

35. 

Lee Y and Hong Y, Lee SR, Chang KT and Hong Y: Autophagy contributes to retardation of cardiac growth in diabetic rats. Lab Anim Res. 28:99–107. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jin C, Yu HY, Park C, Han MH, Hong SH, Kim K, Lee Y, Chang Y, Cheong J, Moon S, Moon S, et al: Oleifolioside B-mediated autophagy promotes apoptosis in A549 human non-small cell lung cancer cells. Int J Oncol 43: 1943-1950, 2013.
APA
Jin, C., Yu, H.Y., Park, C., Han, M.H., Hong, S.H., Kim, K. ... Choi, Y.H. (2013). Oleifolioside B-mediated autophagy promotes apoptosis in A549 human non-small cell lung cancer cells. International Journal of Oncology, 43, 1943-1950. https://doi.org/10.3892/ijo.2013.2143
MLA
Jin, C., Yu, H. Y., Park, C., Han, M. H., Hong, S. H., Kim, K., Lee, Y., Chang, Y., Cheong, J., Moon, S., Kim, G., Moon, H., Kim, W., Lee, J., Choi, Y. H."Oleifolioside B-mediated autophagy promotes apoptosis in A549 human non-small cell lung cancer cells". International Journal of Oncology 43.6 (2013): 1943-1950.
Chicago
Jin, C., Yu, H. Y., Park, C., Han, M. H., Hong, S. H., Kim, K., Lee, Y., Chang, Y., Cheong, J., Moon, S., Kim, G., Moon, H., Kim, W., Lee, J., Choi, Y. H."Oleifolioside B-mediated autophagy promotes apoptosis in A549 human non-small cell lung cancer cells". International Journal of Oncology 43, no. 6 (2013): 1943-1950. https://doi.org/10.3892/ijo.2013.2143
Copy and paste a formatted citation
x
Spandidos Publications style
Jin C, Yu HY, Park C, Han MH, Hong SH, Kim K, Lee Y, Chang Y, Cheong J, Moon S, Moon S, et al: Oleifolioside B-mediated autophagy promotes apoptosis in A549 human non-small cell lung cancer cells. Int J Oncol 43: 1943-1950, 2013.
APA
Jin, C., Yu, H.Y., Park, C., Han, M.H., Hong, S.H., Kim, K. ... Choi, Y.H. (2013). Oleifolioside B-mediated autophagy promotes apoptosis in A549 human non-small cell lung cancer cells. International Journal of Oncology, 43, 1943-1950. https://doi.org/10.3892/ijo.2013.2143
MLA
Jin, C., Yu, H. Y., Park, C., Han, M. H., Hong, S. H., Kim, K., Lee, Y., Chang, Y., Cheong, J., Moon, S., Kim, G., Moon, H., Kim, W., Lee, J., Choi, Y. H."Oleifolioside B-mediated autophagy promotes apoptosis in A549 human non-small cell lung cancer cells". International Journal of Oncology 43.6 (2013): 1943-1950.
Chicago
Jin, C., Yu, H. Y., Park, C., Han, M. H., Hong, S. H., Kim, K., Lee, Y., Chang, Y., Cheong, J., Moon, S., Kim, G., Moon, H., Kim, W., Lee, J., Choi, Y. H."Oleifolioside B-mediated autophagy promotes apoptosis in A549 human non-small cell lung cancer cells". International Journal of Oncology 43, no. 6 (2013): 1943-1950. https://doi.org/10.3892/ijo.2013.2143
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