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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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2014-January Volume 44 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Article

Overexpression of Mortalin in hepatocellular carcinoma and its relationship with angiogenesis and epithelial to mesenchymal transition

  • Authors:
    • Jing Chen
    • Wen-Bin Liu
    • Wei-Dong Jia
    • Ge-Liang Xu
    • Jin-Liang Ma
    • Mei Huang
    • Yan-Ru Deng
    • Jian-Sheng Li
  • View Affiliations / Copyright

    Affiliations: Department of Hepatic Surgery, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230001, P.R. China, Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230001, P.R. China, Laboratory of Emergency Medicine, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230001, P.R. China
  • Pages: 247-255
    |
    Published online on: November 1, 2013
       https://doi.org/10.3892/ijo.2013.2161
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Abstract

Mortalin is highly expressed in a variety of human tumors and associated with tumor metastasis. However, the relationship among the overexpression of Mortalin, epithelial to mesenchymal transition (EMT) and neovascularization is largely unknown. The aim of the present study was to investigate the expression of Mortalin in human HCC cell lines, clinical HCC specimens and its association with angiogenesis and EMT. The results of our study showed that the expression levels of Mortalin in cell lines with higher metastatic potential were significantly higher compared to those with lower metastatic potential. Compared with paracarcinomatous tissues and normal liver tissues, the expression of Mortalin was significantly increased in HCC tumor tissues. The expression of Mortalin was correlated with invasion and metastasis, Edmondson grade and TNM stage. A significant positive correlation was found between the expression of Mortalin and Vimentin, and tumors with high expression of Mortalin had a tendency to higher MVD compared to those with low expression of Mortalin. Using shRNA-mediated Mortalin knockdown, we found that decreased expression of Mortalin was accompanied by a reduction of Vimentin expression. Our findings demonstrated that the overexpression of Mortalin is correlated with the metastatic phenotype of HCC cells and can promote EMT, but cannot induce angiogenesis in HCC. The decreased expression of Mortalin is accompanied by an inhibition of EMT in the HCC cell lines.
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Copy and paste a formatted citation
Spandidos Publications style
Chen J, Liu W, Jia W, Xu G, Ma J, Huang M, Deng Y and Li J: Overexpression of Mortalin in hepatocellular carcinoma and its relationship with angiogenesis and epithelial to mesenchymal transition. Int J Oncol 44: 247-255, 2014.
APA
Chen, J., Liu, W., Jia, W., Xu, G., Ma, J., Huang, M. ... Li, J. (2014). Overexpression of Mortalin in hepatocellular carcinoma and its relationship with angiogenesis and epithelial to mesenchymal transition. International Journal of Oncology, 44, 247-255. https://doi.org/10.3892/ijo.2013.2161
MLA
Chen, J., Liu, W., Jia, W., Xu, G., Ma, J., Huang, M., Deng, Y., Li, J."Overexpression of Mortalin in hepatocellular carcinoma and its relationship with angiogenesis and epithelial to mesenchymal transition". International Journal of Oncology 44.1 (2014): 247-255.
Chicago
Chen, J., Liu, W., Jia, W., Xu, G., Ma, J., Huang, M., Deng, Y., Li, J."Overexpression of Mortalin in hepatocellular carcinoma and its relationship with angiogenesis and epithelial to mesenchymal transition". International Journal of Oncology 44, no. 1 (2014): 247-255. https://doi.org/10.3892/ijo.2013.2161
Copy and paste a formatted citation
x
Spandidos Publications style
Chen J, Liu W, Jia W, Xu G, Ma J, Huang M, Deng Y and Li J: Overexpression of Mortalin in hepatocellular carcinoma and its relationship with angiogenesis and epithelial to mesenchymal transition. Int J Oncol 44: 247-255, 2014.
APA
Chen, J., Liu, W., Jia, W., Xu, G., Ma, J., Huang, M. ... Li, J. (2014). Overexpression of Mortalin in hepatocellular carcinoma and its relationship with angiogenesis and epithelial to mesenchymal transition. International Journal of Oncology, 44, 247-255. https://doi.org/10.3892/ijo.2013.2161
MLA
Chen, J., Liu, W., Jia, W., Xu, G., Ma, J., Huang, M., Deng, Y., Li, J."Overexpression of Mortalin in hepatocellular carcinoma and its relationship with angiogenesis and epithelial to mesenchymal transition". International Journal of Oncology 44.1 (2014): 247-255.
Chicago
Chen, J., Liu, W., Jia, W., Xu, G., Ma, J., Huang, M., Deng, Y., Li, J."Overexpression of Mortalin in hepatocellular carcinoma and its relationship with angiogenesis and epithelial to mesenchymal transition". International Journal of Oncology 44, no. 1 (2014): 247-255. https://doi.org/10.3892/ijo.2013.2161
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