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Article

Close correlation between MEK/ERK and Aurora-B signaling pathways in sustaining tumorigenic potential and radioresistance of gynecological cancer cell lines

  • Authors:
    • Francesco Marampon
    • Giovanni Luca Gravina
    • Valdimir M. Popov
    • Luca Scarsella
    • Claudio Festuccia
    • Maria Emilia La Verghetta
    • Silvia Parente
    • Manuela Cerasani
    • Gemma Bruera
    • Corrado Ficorella
    • Enrico Ricevuto
    • Vincenzo Tombolini
    • Ernesto Di Cesare
    • Bianca Maria Zani
  • View Affiliations / Copyright

    Affiliations: Department of Biotechnological and Applied Clinical Sciences, Division of Radiotherapy and Radiobiology Laboratory, San Salvatore Hospital, University of L'Aquila, I-67100 L'Aquila, Italy, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, I-67100 L'Aquila, Italy, LIPOGEN LLC, Mount Laurel, NJ 08054, USA, Medical Oncology, S. Salvatore Hospital, University of L'Aquila, L'Aquila, I-67100, Italy, Department of Radiological Sciences-Oncology and Pathological Anatomy, and Department of Radiotherapy, University of Rome ‘La Sapienza’, I-00161 Rome, Italy
  • Pages: 285-294
    |
    Published online on: November 5, 2013
       https://doi.org/10.3892/ijo.2013.2167
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Abstract

Both Aurora-A and -B kinases have been implicated in tumorigenesis; and as such, they represent an attractive therapeutic target. Recent studies found that Aurora-A is a downstream target of mitogen-activated protein kinase 1/ERK2, while Aurora-B has been found to be a prognostic/predictive therapeutic target for epithelial cancer. In a wide range of human cancers, the Ras/Raf/MEK/ERK/MAP kinase pathway is enhanced and the cellular response to growth signals is known to increase. The purpose of this study was to investigate whether the MEK/ERK cascade regulates tumorigenic signaling and radioresistance via the Aurora-B-mediated pathway in a panel of gynecological cancer cell lines. Exponentially growing human endometrial (Ishikawa), cervical (HeLa), cervical (CASKI) and vulva (SiHa) cancer cells were used in culture treated with either control or MEK/ERK inhibitor or AZD1152 before and after irradiation. Western blotting, ERK1/2 siRNA transfection, growth assay in modified monolayer, Annexin V and migration/invasion assays were performed. The specific MEK/ERK inhibitor U0126 decreased the tumorigenic potential and improved the radiation response in all cellular models. The modulation of radioresponse upon U0126 treatment positively correlated with the inhibition of phospho-ERKs and the reduction of Aurora-B kinase expression. In addition, upon U0126 treatment DNA-PKcs protein expression was found to be downregulated, indicating that the improved radiation response may be caused by decreased DNA double-strand damage repair mechanisms. The knockdown of ERK by siRNA confirmed the MEK/ERK-dependent Aurora-B kinase expression. The use of AZD1152, a selective Aurora-B inhibitor, counteracted tumorigenic potential and radioresistance phenotype by highly increasing apoptotic mechanisms in all gynecological cancer cell lines used. Evidence from our experiments show that tumorigenic potential and radiation response in gynecological cancer cells may ensue from a MEK/ERK or Aurora-B inhibition. Together with the close correlation of MEK/ERK and Aurora-B protein expression, this study underlines the potential role of a MEK/ERK/Aurora-B axis whose interruption recovers the antitumor effects of radiotherapy.
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View References

1. 

Weiderpass E and Labrèche F: Malignant tumors of the female reproductive system. Saf Health Work. 3:166–180. 2012. View Article : Google Scholar : PubMed/NCBI

2. 

Sharma DN: Radiation in vulvar cancer. Curr Opin Obstet Gynecol. 24:24–30. 2012. View Article : Google Scholar

3. 

Wright JD, Barrena Medel NI, Sehouli J, Fujiwara K and Herzog TJ: Contemporary management of endometrial cancer. Lancet. 379:1352–1360. 2012. View Article : Google Scholar : PubMed/NCBI

4. 

Willmott LJ and Monk BJ: Cervical cancer therapy: current, future and anti-angiogensis targeted treatment. Expert Rev Anticancer Ther. 9:895–903. 2009. View Article : Google Scholar : PubMed/NCBI

5. 

McKenna WG, Weiss MC, Bakanauskas VJ, et al: The role of the H-ras oncogene in radiation resistance and metastasis. Int J Radiat Oncol Biol Phys. 18:849–859. 1990. View Article : Google Scholar : PubMed/NCBI

6. 

Jones HA, Hahn SM, Bernhard E and McKenna WG: Ras inhibitors and radiation therapy. Semin Radiat Oncol. 11:328–337. 2001. View Article : Google Scholar

7. 

Dar AA, Goff LW, Majid S, Berlin J and El-Rifai W: Aurora kinase inhibitors-rising stars in cancer therapeutics? Mol Cancer Ther. 9:268–278. 2010. View Article : Google Scholar : PubMed/NCBI

8. 

O’Neill E and Kolch W: Conferring specificity on the ubiquitous Raf/MEK signaling pathway. Br J Cancer. 90:283–288. 2004.PubMed/NCBI

9. 

Murphy LO and Blenis J: MAPK signal specificity: the right place at the right time. Trends Biochem Sci. 31:268–275. 2006. View Article : Google Scholar : PubMed/NCBI

10. 

Kohno M and Pouyssegur J: Pharmacological inhibitors of the ERK signaling pathway: application as anticancer drugs. Prog Cell Cycle Res. 5:219–224. 2003.PubMed/NCBI

11. 

Faivre S, Djelloul S and Raymond E: New paradigms in anti-cancer therapy: targeting multiple signaling pathways with kinase inhibitors. Semin Oncol. 33:407–420. 2006. View Article : Google Scholar : PubMed/NCBI

12. 

Liu D, Liu Z, Condouris S and Xing M: BRAF V600E maintains proliferation, transformation, and tumorigenicity of BRAF-mutant papillary thyroid cancer cells. J Clin Endocrinol Metab. 92:2264–2271. 2007. View Article : Google Scholar : PubMed/NCBI

13. 

Martinelli S, McDowell HP, Vigne SD, Kokai G, Uccini S and Tartaglia M: RAS signaling dysregulation in human embryonal rhabdomyosarcoma. Genes Chromosomes Cancer. 48:975–982. 2009. View Article : Google Scholar : PubMed/NCBI

14. 

Marshall CJ: The ras oncogenes. J Cell Sci. 10:157–169. 1998.

15. 

Gupta AK, Bakanauskas VJ, Cerniglia GJ, et al: The Ras radiation resistance pathway. Cancer Res. 61:4278–4282. 2001.PubMed/NCBI

16. 

Toulany M, Baumann M and Rodemann HP: Stimulated PI3K-AKT signaling mediated through ligand or radiation-induced EGFR depends indirectly, but not directly, on constitutive K-Ras activity. Mol Cancer Res. 5:863–872. 2007. View Article : Google Scholar : PubMed/NCBI

17. 

Adhikary S and Eilers M: Transcriptional regulation and transformation by Myc proteins. Nat Rev Mol Cell Biol. 6:635–645. 2005. View Article : Google Scholar : PubMed/NCBI

18. 

Mammas IN, Zafiropoulos A and Spandidos DA: Involvement of the ras genes in female genital tract cancer. Int J Oncol. 26:1241–1255. 2005.PubMed/NCBI

19. 

Carmena M and Earnshaw WC: The cellular geography of aurora kinases. Nat Rev Mol Cell Biol. 4:842–854. 2003. View Article : Google Scholar : PubMed/NCBI

20. 

Ducat D and Zheng Y: Aurora kinases in spindle assembly and chromosome segregation. Exp Cell Res. 301:60–67. 2004. View Article : Google Scholar : PubMed/NCBI

21. 

Marumoto T, Zhang D and Saya H: Aurora A, a guardian of poles. Nat Rev Cancer. 5:42–50. 2005. View Article : Google Scholar : PubMed/NCBI

22. 

Fu J, Bian M, Jiang Q and Zhang C: Roles of Aurora kinases in mitosis and tumorigenesis. Mol Cancer Res. 5:1–10. 2007. View Article : Google Scholar : PubMed/NCBI

23. 

Kobayashi M, Nakamura S, Ono T, et al: Analysis of aurora kinase expressions and cell cycle regulation by Aurora C in leukemia cells. Blood (ASH Annual Meeting Abstracts). 108:13662006.

24. 

Slattery SD, Mancini MA, Brinkley BR and Hall RM: Aurora-C kinase supports mitotic progression in the absence of Aurora-B. Cell Cycle. 8:2986–2997. 2009. View Article : Google Scholar : PubMed/NCBI

25. 

Zhang X: Aurora kinases. Curr Biol. 18:R146–R148. 2008. View Article : Google Scholar : PubMed/NCBI

26. 

Carvajal RD, Tse A and Schwartz GK: Aurora kinases: new targets for cancer therapy. Clin Cancer Res. 12:6869–6875. 2006. View Article : Google Scholar : PubMed/NCBI

27. 

Girdler F, Gascoigne KE, Eyers PA, et al: Validating Aurora B as an anti-cancer drug target. J Cell Sci. 119:3664–3675. 2006. View Article : Google Scholar : PubMed/NCBI

28. 

Smith SL, Bowers NL, Betticher DC, et al: Overexpression of Aurora B kinase (AURBK) in primary non-small cell lung carcinoma is frequent, generally driven from one allele, and correlates with the level of genetic instability. Br J Cancer. 93:719–729. 2005. View Article : Google Scholar : PubMed/NCBI

29. 

Gautschi O, Heighway J, Mack PC, Purnell PR, Lara PN Jr and Gandara DR: Aurora kinases as anticancer drug targets. Clin Cancer Res. 14:1639–1648. 2008. View Article : Google Scholar : PubMed/NCBI

30. 

Keen M and Taylor S: Mitotic drivers - inhibitors of the Aurora B kinase. Cancer Metastasis Rev. 28:185–195. 2009. View Article : Google Scholar

31. 

Bonet C, Giuliano S, Ohanna M, et al: Aurora B is regulated by the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling pathway and is a valuable potential target in melanoma cells. J Biol Chem. 287:29887–29898. 2012. View Article : Google Scholar

32. 

Marampon F, Gravina GL, Di Rocco A, et al: MEK/ERK inhibitor U0126 increases the radiosensitivity of rhabdomyosarcoma cells in vitro and in vivo by downregulating growth and DNA repair signals. Mol Cancer Ther. 10:159–168. 2011. View Article : Google Scholar : PubMed/NCBI

33. 

Marampon F, Bossi G, Ciccarelli C, et al: MEK/ERK inhibitor U0126 affects in vitro and in vivo growth of embryonal rhabdomyosarcoma. Mol Cancer Ther. 8:543–551. 2009. View Article : Google Scholar : PubMed/NCBI

34. 

Marampon F, Ciccarelli C and Zani BM: Down-regulation of c-Myc following MEK/ERK inhibition halts the expression of malignant phenotype in rhabdomyosarcoma and in non muscle-derived human tumors. Mol Cancer. 5:312009. View Article : Google Scholar : PubMed/NCBI

35. 

Allalunis-Turner MJ, Zia PK, Barron GM, Mirzayans R and Day RS III: Radiation-induced DNA damage and repair in cells of a radiosensitive human malignant glioma cell line. Radiat Res. 144:288–293. 1995. View Article : Google Scholar : PubMed/NCBI

36. 

Lees-Miller SP, Godbout R, Chan DW, Weinfeld M, Day RS III, Barron GM and Allalunis-Turner J: Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line. Science. 267:1183–1185. 1995. View Article : Google Scholar : PubMed/NCBI

37. 

Tian X, Chen G, Xing H, Weng D, Guo Y and Ma D: The relationship between the down-regulation of DNA-PKcs or Ku70 and the chemosensitization in human cervical carcinoma cell line HeLa. Oncol Rep. 18:927–932. 2007.PubMed/NCBI

38. 

Gerweck LE, Vijayappa S, Kurimasa A, Ogawa K and Chen DJ: Tumor cell radiosensitivity is a major determinant of tumor response to radiation. Cancer Res. 66:8352–8355. 2006. View Article : Google Scholar : PubMed/NCBI

39. 

van Gent DC, Hoeijmakers JH and Kanaar R: Chromosomal stability and the DNA double-stranded break connection. Nat Rev Genet. 2:196–206. 2001.

40. 

Lowry OH, Rosebrough NJ, Farr AL and Randall RJ: Protein measurement with the Folin phenol reagent. Biol Chem. 193:265–275. 1951.PubMed/NCBI

41. 

Mori S, Chang JT, Andrechek ER, et al: Anchorage-independent cell growth signature identifies tumors with metastatic potential. Oncogene. 28:2796–2805. 2009. View Article : Google Scholar : PubMed/NCBI

42. 

Sak A, Stuschke M, Groneberg M, Kübler D, Pöttgen C and Eberhardt WE: Inhibiting the Aurora B kinase potently suppresses repopulation during fractionated irradiation of human lung cancer cell lines. Int J Radiat Oncol Biol Phys. 84:492–499. 2012. View Article : Google Scholar : PubMed/NCBI

43. 

Borges KS, Castro-Gamero AM, Moreno DA, et al: Inhibition of Aurora kinases enhances chemosensitivity to temozolomide and causes radiosensitization in glioblastoma cells. J Cancer Res Clin Oncol. 138:405–414. 2012. View Article : Google Scholar : PubMed/NCBI

44. 

Niermann KJ, Moretti L, Giacalone NJ, et al: Enhanced radiosensitivity of androgen-resistant prostate cancer: AZD1152-mediated Aurora kinase B inhibition. Radiat Res. 175:444–451. 2011. View Article : Google Scholar : PubMed/NCBI

45. 

Kosik A, Bekier ME, Katusin JD, et al: Investigating the role of Aurora kinases in RAS signaling. J Cell Biochem. 106:33–41. 2009. View Article : Google Scholar : PubMed/NCBI

46. 

Ma Y, Weimer J, Fredrik R, et al: Aurora kinase inhibitor AZD1152 has an additional effect of platinum on a sequential application at the human ovarian cancer cell line SKOV3. Arch Gynecol Obstet. 288:173–182. 2013. View Article : Google Scholar : PubMed/NCBI

47. 

Baldini E, Sorrenti S, D’Armiento E, et al: Aurora kinases: new molecular targets in thyroid cancer therapy. Clin Ter. 163:e457–462. 2012.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Marampon F, Gravina GL, Popov VM, Scarsella L, Festuccia C, La Verghetta ME, Parente S, Cerasani M, Bruera G, Ficorella C, Ficorella C, et al: Close correlation between MEK/ERK and Aurora-B signaling pathways in sustaining tumorigenic potential and radioresistance of gynecological cancer cell lines. Int J Oncol 44: 285-294, 2014.
APA
Marampon, F., Gravina, G.L., Popov, V.M., Scarsella, L., Festuccia, C., La Verghetta, M.E. ... Zani, B.M. (2014). Close correlation between MEK/ERK and Aurora-B signaling pathways in sustaining tumorigenic potential and radioresistance of gynecological cancer cell lines. International Journal of Oncology, 44, 285-294. https://doi.org/10.3892/ijo.2013.2167
MLA
Marampon, F., Gravina, G. L., Popov, V. M., Scarsella, L., Festuccia, C., La Verghetta, M. E., Parente, S., Cerasani, M., Bruera, G., Ficorella, C., Ricevuto, E., Tombolini, V., Di Cesare, E., Zani, B. M."Close correlation between MEK/ERK and Aurora-B signaling pathways in sustaining tumorigenic potential and radioresistance of gynecological cancer cell lines". International Journal of Oncology 44.1 (2014): 285-294.
Chicago
Marampon, F., Gravina, G. L., Popov, V. M., Scarsella, L., Festuccia, C., La Verghetta, M. E., Parente, S., Cerasani, M., Bruera, G., Ficorella, C., Ricevuto, E., Tombolini, V., Di Cesare, E., Zani, B. M."Close correlation between MEK/ERK and Aurora-B signaling pathways in sustaining tumorigenic potential and radioresistance of gynecological cancer cell lines". International Journal of Oncology 44, no. 1 (2014): 285-294. https://doi.org/10.3892/ijo.2013.2167
Copy and paste a formatted citation
x
Spandidos Publications style
Marampon F, Gravina GL, Popov VM, Scarsella L, Festuccia C, La Verghetta ME, Parente S, Cerasani M, Bruera G, Ficorella C, Ficorella C, et al: Close correlation between MEK/ERK and Aurora-B signaling pathways in sustaining tumorigenic potential and radioresistance of gynecological cancer cell lines. Int J Oncol 44: 285-294, 2014.
APA
Marampon, F., Gravina, G.L., Popov, V.M., Scarsella, L., Festuccia, C., La Verghetta, M.E. ... Zani, B.M. (2014). Close correlation between MEK/ERK and Aurora-B signaling pathways in sustaining tumorigenic potential and radioresistance of gynecological cancer cell lines. International Journal of Oncology, 44, 285-294. https://doi.org/10.3892/ijo.2013.2167
MLA
Marampon, F., Gravina, G. L., Popov, V. M., Scarsella, L., Festuccia, C., La Verghetta, M. E., Parente, S., Cerasani, M., Bruera, G., Ficorella, C., Ricevuto, E., Tombolini, V., Di Cesare, E., Zani, B. M."Close correlation between MEK/ERK and Aurora-B signaling pathways in sustaining tumorigenic potential and radioresistance of gynecological cancer cell lines". International Journal of Oncology 44.1 (2014): 285-294.
Chicago
Marampon, F., Gravina, G. L., Popov, V. M., Scarsella, L., Festuccia, C., La Verghetta, M. E., Parente, S., Cerasani, M., Bruera, G., Ficorella, C., Ricevuto, E., Tombolini, V., Di Cesare, E., Zani, B. M."Close correlation between MEK/ERK and Aurora-B signaling pathways in sustaining tumorigenic potential and radioresistance of gynecological cancer cell lines". International Journal of Oncology 44, no. 1 (2014): 285-294. https://doi.org/10.3892/ijo.2013.2167
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