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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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2014-January Volume 44 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Suppression of SCIN inhibits human prostate cancer cell proliferation and induces G0/G1 phase arrest

  • Authors:
    • Dong Wang
    • Shu-Qing Sun
    • Ying-Hao Yu
    • Wei-Zhen Wu
    • Shun-Liang Yang
    • Jian-Ming Tan
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Fuzhou General Hospital, Fuzhou 350025, P.R. China, Department of Blood Purification, Fuzhou General Hospital, Fuzhou 350025, P.R. China, Department of Pathology, Fuzhou General Hospital, Fuzhou 350025, P.R. China
  • Pages: 161-166
    |
    Published online on: November 8, 2013
       https://doi.org/10.3892/ijo.2013.2170
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Abstract

SCIN is a calcium regulated actin severing and capping protein. Its homologue in zebrafish is found to be related with cell death. In the present study, we found that SCIN is highly expressed in human prostate cancer specimens. However, the functions of SCIN in human prostate carcinoma cells are largely unknown. To address the function of SCIN in prostate carcinoma cells, we used lentivirus-mediated RNAi to knock down SCIN expression in PC3 cells, a prostate carcinoma cell line. We found that in vitro silencing of SCIN could inhibit the proliferation and colony formation ability of PC3 cells. Furthermore, cell cycle analysis showed that reduced SCIN expression lead to G0/G1 cell cycle arrest through the regulation of cell cycle-related genes, such as p21Waf1/Cip1, cyclin-dependent kinase inhibitor 2A (CDKN2A, p16Ink4A) and cyclin A2. These results suggest that SCIN plays an important role in the proliferation of prostate cancer cells and lentivirus-mediated inhibition of SCIN expression may be a potential therapeutic method for the treatment of prostate cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Wang D, Sun S, Yu Y, Wu W, Yang S and Tan J: Suppression of SCIN inhibits human prostate cancer cell proliferation and induces G0/G1 phase arrest. Int J Oncol 44: 161-166, 2014.
APA
Wang, D., Sun, S., Yu, Y., Wu, W., Yang, S., & Tan, J. (2014). Suppression of SCIN inhibits human prostate cancer cell proliferation and induces G0/G1 phase arrest. International Journal of Oncology, 44, 161-166. https://doi.org/10.3892/ijo.2013.2170
MLA
Wang, D., Sun, S., Yu, Y., Wu, W., Yang, S., Tan, J."Suppression of SCIN inhibits human prostate cancer cell proliferation and induces G0/G1 phase arrest". International Journal of Oncology 44.1 (2014): 161-166.
Chicago
Wang, D., Sun, S., Yu, Y., Wu, W., Yang, S., Tan, J."Suppression of SCIN inhibits human prostate cancer cell proliferation and induces G0/G1 phase arrest". International Journal of Oncology 44, no. 1 (2014): 161-166. https://doi.org/10.3892/ijo.2013.2170
Copy and paste a formatted citation
x
Spandidos Publications style
Wang D, Sun S, Yu Y, Wu W, Yang S and Tan J: Suppression of SCIN inhibits human prostate cancer cell proliferation and induces G0/G1 phase arrest. Int J Oncol 44: 161-166, 2014.
APA
Wang, D., Sun, S., Yu, Y., Wu, W., Yang, S., & Tan, J. (2014). Suppression of SCIN inhibits human prostate cancer cell proliferation and induces G0/G1 phase arrest. International Journal of Oncology, 44, 161-166. https://doi.org/10.3892/ijo.2013.2170
MLA
Wang, D., Sun, S., Yu, Y., Wu, W., Yang, S., Tan, J."Suppression of SCIN inhibits human prostate cancer cell proliferation and induces G0/G1 phase arrest". International Journal of Oncology 44.1 (2014): 161-166.
Chicago
Wang, D., Sun, S., Yu, Y., Wu, W., Yang, S., Tan, J."Suppression of SCIN inhibits human prostate cancer cell proliferation and induces G0/G1 phase arrest". International Journal of Oncology 44, no. 1 (2014): 161-166. https://doi.org/10.3892/ijo.2013.2170
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