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Differential prognosis of metastatic colorectal cancer patients post-progression to first-line triplet chemotherapy plus bevacizumab, FIr-B/FOx, according to second-line treatment and KRAS genotype

  • Authors:
    • Gemma Bruera
    • Katia Cannita
    • Aldo Victor Giordano
    • Roberto Vicentini
    • Corrado Ficorella
    • Enrico Ricevuto
  • View Affiliations / Copyright

    Affiliations: Medical Oncology, S. Salvatore Hospital, University of L'Aquila, I-67100 L'Aquila, Italy, Radiology, S. Salvatore Hospital, University of L'Aquila, I-67100 L'Aquila, Italy, Hepatobiliary-Pancreatic Surgery, S. Salvatore Hospital, University of L'Aquila, I-67100 L'Aquila, Italy
    Copyright: © Bruera et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 17-26
    |
    Published online on: November 15, 2013
       https://doi.org/10.3892/ijo.2013.2179
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Abstract

Clinical outcome post-progression to first-line triplet chemotherapy (CT) plus bevacizumab (FIr-B/FOx) was evaluated in metastatic colorectal cancer (MCRC) patients (pts). Second-line treatment was selected according to fitness, KRAS genotype, previous efficacy and safety. Efficacy was evaluated and compared according to treatment or KRAS genotype, using log-rank analysis. Among 54 pts, median overall survival (OS) post-progression was 12 months, significantly better in 40 (74.1%) treated compared to 14 (25.9%) who died without further treatment. Second-line surgical treatment, 4 pts (7.4%), medical treatment, 36 pts (66.7%): triplet CT plus targeted agent, 10 (18.5%); triplet regimens, 19 (35.2%); doublet/monotherapy, 7 (13%). At follow-up of 14 months, objective response rate (ORR) was 38%, metastasectomies 12.5%, progression-free survival (PFS) 10 months, OS 14 months. According to treatment, ORR, metastasectomies, PFS and OS were significantly favourable in triplet CT plus targeted agent compared to triplet, respectively: 80%, 40%, 13 months, not reached; 28%, 6%, 8 months, 11 months. PFS and OS were significantly worse in c.35 G>A mutant compared to wild-type and/or other mutant patients. Prognosis after progression to first‑line FIr-B/FOx may be significantly favourable in MCRC pts re-challenged with intensive regimens, and unfavourable in c.35 G>A KRAS mutant patients.
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Copy and paste a formatted citation
Spandidos Publications style
Bruera G, Cannita K, Giordano AV, Vicentini R, Ficorella C and Ricevuto E: Differential prognosis of metastatic colorectal cancer patients post-progression to first-line triplet chemotherapy plus bevacizumab, FIr-B/FOx, according to second-line treatment and KRAS genotype. Int J Oncol 44: 17-26, 2014.
APA
Bruera, G., Cannita, K., Giordano, A.V., Vicentini, R., Ficorella, C., & Ricevuto, E. (2014). Differential prognosis of metastatic colorectal cancer patients post-progression to first-line triplet chemotherapy plus bevacizumab, FIr-B/FOx, according to second-line treatment and KRAS genotype. International Journal of Oncology, 44, 17-26. https://doi.org/10.3892/ijo.2013.2179
MLA
Bruera, G., Cannita, K., Giordano, A. V., Vicentini, R., Ficorella, C., Ricevuto, E."Differential prognosis of metastatic colorectal cancer patients post-progression to first-line triplet chemotherapy plus bevacizumab, FIr-B/FOx, according to second-line treatment and KRAS genotype". International Journal of Oncology 44.1 (2014): 17-26.
Chicago
Bruera, G., Cannita, K., Giordano, A. V., Vicentini, R., Ficorella, C., Ricevuto, E."Differential prognosis of metastatic colorectal cancer patients post-progression to first-line triplet chemotherapy plus bevacizumab, FIr-B/FOx, according to second-line treatment and KRAS genotype". International Journal of Oncology 44, no. 1 (2014): 17-26. https://doi.org/10.3892/ijo.2013.2179
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x
Spandidos Publications style
Bruera G, Cannita K, Giordano AV, Vicentini R, Ficorella C and Ricevuto E: Differential prognosis of metastatic colorectal cancer patients post-progression to first-line triplet chemotherapy plus bevacizumab, FIr-B/FOx, according to second-line treatment and KRAS genotype. Int J Oncol 44: 17-26, 2014.
APA
Bruera, G., Cannita, K., Giordano, A.V., Vicentini, R., Ficorella, C., & Ricevuto, E. (2014). Differential prognosis of metastatic colorectal cancer patients post-progression to first-line triplet chemotherapy plus bevacizumab, FIr-B/FOx, according to second-line treatment and KRAS genotype. International Journal of Oncology, 44, 17-26. https://doi.org/10.3892/ijo.2013.2179
MLA
Bruera, G., Cannita, K., Giordano, A. V., Vicentini, R., Ficorella, C., Ricevuto, E."Differential prognosis of metastatic colorectal cancer patients post-progression to first-line triplet chemotherapy plus bevacizumab, FIr-B/FOx, according to second-line treatment and KRAS genotype". International Journal of Oncology 44.1 (2014): 17-26.
Chicago
Bruera, G., Cannita, K., Giordano, A. V., Vicentini, R., Ficorella, C., Ricevuto, E."Differential prognosis of metastatic colorectal cancer patients post-progression to first-line triplet chemotherapy plus bevacizumab, FIr-B/FOx, according to second-line treatment and KRAS genotype". International Journal of Oncology 44, no. 1 (2014): 17-26. https://doi.org/10.3892/ijo.2013.2179
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