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Article

Prolonged androgen deprivation leads to overexpression of calpain 2: Implications for prostate cancer progression

  • Authors:
    • Tiancheng Liu
    • Desiree E. Mendes
    • Clifford E. Berkman
  • View Affiliations / Copyright

    Affiliations: Department of Chemistry, Washington State University, Pullman, WA 99164, USA
  • Pages: 467-472
    |
    Published online on: November 29, 2013
       https://doi.org/10.3892/ijo.2013.2196
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Abstract

Understanding the molecular mechanism of prostate cancer progression from androgen dependence to independence may lead to developing more effective treatments against prostate cancer. Herein, our previous in vitro model was employed to assess the effects of continuous androgen-deprivation on developing the metastatic phenotype from androgen-dependent prostate cancer cells (LNCaP). The results indicated that long-term androgen deprivation resulted in overexpression of calpain 2 and increased expression of filamin A (FlnA), but not for calpain 1. The enhanced activity of calpain 2 was confirmed by the accumulation of cleaved FlnA fragments, which could be effectively blocked by calpeptin (an inhibitor of calpain 2). Therefore, the combination of calpain 2 inhibitor and androgen deprivation may provide new therapeutic strategy for patients to prevent or postpone prostate cancer progression.
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Copy and paste a formatted citation
Spandidos Publications style
Liu T, Mendes DE and Berkman CE: Prolonged androgen deprivation leads to overexpression of calpain 2: Implications for prostate cancer progression. Int J Oncol 44: 467-472, 2014.
APA
Liu, T., Mendes, D.E., & Berkman, C.E. (2014). Prolonged androgen deprivation leads to overexpression of calpain 2: Implications for prostate cancer progression. International Journal of Oncology, 44, 467-472. https://doi.org/10.3892/ijo.2013.2196
MLA
Liu, T., Mendes, D. E., Berkman, C. E."Prolonged androgen deprivation leads to overexpression of calpain 2: Implications for prostate cancer progression". International Journal of Oncology 44.2 (2014): 467-472.
Chicago
Liu, T., Mendes, D. E., Berkman, C. E."Prolonged androgen deprivation leads to overexpression of calpain 2: Implications for prostate cancer progression". International Journal of Oncology 44, no. 2 (2014): 467-472. https://doi.org/10.3892/ijo.2013.2196
Copy and paste a formatted citation
x
Spandidos Publications style
Liu T, Mendes DE and Berkman CE: Prolonged androgen deprivation leads to overexpression of calpain 2: Implications for prostate cancer progression. Int J Oncol 44: 467-472, 2014.
APA
Liu, T., Mendes, D.E., & Berkman, C.E. (2014). Prolonged androgen deprivation leads to overexpression of calpain 2: Implications for prostate cancer progression. International Journal of Oncology, 44, 467-472. https://doi.org/10.3892/ijo.2013.2196
MLA
Liu, T., Mendes, D. E., Berkman, C. E."Prolonged androgen deprivation leads to overexpression of calpain 2: Implications for prostate cancer progression". International Journal of Oncology 44.2 (2014): 467-472.
Chicago
Liu, T., Mendes, D. E., Berkman, C. E."Prolonged androgen deprivation leads to overexpression of calpain 2: Implications for prostate cancer progression". International Journal of Oncology 44, no. 2 (2014): 467-472. https://doi.org/10.3892/ijo.2013.2196
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