Prolonged androgen deprivation leads to overexpression of calpain 2: Implications for prostate cancer progression

  • Authors:
    • Tiancheng Liu
    • Desiree E. Mendes
    • Clifford E. Berkman
  • View Affiliations

  • Published online on: November 29, 2013     https://doi.org/10.3892/ijo.2013.2196
  • Pages: 467-472
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Abstract

Understanding the molecular mechanism of prostate cancer progression from androgen dependence to independence may lead to developing more effective treatments against prostate cancer. Herein, our previous in vitro model was employed to assess the effects of continuous androgen-deprivation on developing the metastatic phenotype from androgen-dependent prostate cancer cells (LNCaP). The results indicated that long-term androgen deprivation resulted in overexpression of calpain 2 and increased expression of filamin A (FlnA), but not for calpain 1. The enhanced activity of calpain 2 was confirmed by the accumulation of cleaved FlnA fragments, which could be effectively blocked by calpeptin (an inhibitor of calpain 2). Therefore, the combination of calpain 2 inhibitor and androgen deprivation may provide new therapeutic strategy for patients to prevent or postpone prostate cancer progression.
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2014-February
Volume 44 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Liu T, Mendes DE and Berkman CE: Prolonged androgen deprivation leads to overexpression of calpain 2: Implications for prostate cancer progression. Int J Oncol 44: 467-472, 2014
APA
Liu, T., Mendes, D.E., & Berkman, C.E. (2014). Prolonged androgen deprivation leads to overexpression of calpain 2: Implications for prostate cancer progression. International Journal of Oncology, 44, 467-472. https://doi.org/10.3892/ijo.2013.2196
MLA
Liu, T., Mendes, D. E., Berkman, C. E."Prolonged androgen deprivation leads to overexpression of calpain 2: Implications for prostate cancer progression". International Journal of Oncology 44.2 (2014): 467-472.
Chicago
Liu, T., Mendes, D. E., Berkman, C. E."Prolonged androgen deprivation leads to overexpression of calpain 2: Implications for prostate cancer progression". International Journal of Oncology 44, no. 2 (2014): 467-472. https://doi.org/10.3892/ijo.2013.2196