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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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2014-February Volume 44 Issue 2

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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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Review

Circadian disruption and cancer risk: A new concept of stromal niche (Review)

  • Authors:
    • Hiroto Izumi
    • Keyong Wang
    • Yasuo Morimoto
    • Yasuyuki Sasaguri
    • Kimitoshi Kohno
  • View Affiliations / Copyright

    Affiliations: Department of Occupational Pneumology, Institute of Industrial Ecological Science, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan, Bio-information Research Center, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan, Center for Promotion of Clinical and Translational Research, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan, The President Laboratory, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
  • Pages: 364-370
    |
    Published online on: November 29, 2013
       https://doi.org/10.3892/ijo.2013.2201
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Abstract

Circadian rhythms regulate a variety of physiological functions. Epidemiological evidence indicates that disruption of these circadian rhythms might be linked to cancer. In general, imbalances in homeostasis, such as immune and hormonal dysfunctions, are thought to be involved in cancer development. The results of a recent study suggested that circadian disruption may induce stromal changes associated with cancer risk, highlighting the importance of the cancer stem cell niche for protecting cancer cells. Current research provides new concepts and clarification regarding the function of the tumor niche, and the new concept of a stromal niche may help us to understand the additional functions of both cancer-associated fibroblasts and the extracellular matrix. In this review, we summarize our current knowledge regarding the role of circadian rhythms in cancer risk and the relevance of the stromal niche in cancer cell survival and progression.
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Copy and paste a formatted citation
Spandidos Publications style
Izumi H, Wang K, Morimoto Y, Sasaguri Y and Kohno K: Circadian disruption and cancer risk: A new concept of stromal niche (Review). Int J Oncol 44: 364-370, 2014.
APA
Izumi, H., Wang, K., Morimoto, Y., Sasaguri, Y., & Kohno, K. (2014). Circadian disruption and cancer risk: A new concept of stromal niche (Review). International Journal of Oncology, 44, 364-370. https://doi.org/10.3892/ijo.2013.2201
MLA
Izumi, H., Wang, K., Morimoto, Y., Sasaguri, Y., Kohno, K."Circadian disruption and cancer risk: A new concept of stromal niche (Review)". International Journal of Oncology 44.2 (2014): 364-370.
Chicago
Izumi, H., Wang, K., Morimoto, Y., Sasaguri, Y., Kohno, K."Circadian disruption and cancer risk: A new concept of stromal niche (Review)". International Journal of Oncology 44, no. 2 (2014): 364-370. https://doi.org/10.3892/ijo.2013.2201
Copy and paste a formatted citation
x
Spandidos Publications style
Izumi H, Wang K, Morimoto Y, Sasaguri Y and Kohno K: Circadian disruption and cancer risk: A new concept of stromal niche (Review). Int J Oncol 44: 364-370, 2014.
APA
Izumi, H., Wang, K., Morimoto, Y., Sasaguri, Y., & Kohno, K. (2014). Circadian disruption and cancer risk: A new concept of stromal niche (Review). International Journal of Oncology, 44, 364-370. https://doi.org/10.3892/ijo.2013.2201
MLA
Izumi, H., Wang, K., Morimoto, Y., Sasaguri, Y., Kohno, K."Circadian disruption and cancer risk: A new concept of stromal niche (Review)". International Journal of Oncology 44.2 (2014): 364-370.
Chicago
Izumi, H., Wang, K., Morimoto, Y., Sasaguri, Y., Kohno, K."Circadian disruption and cancer risk: A new concept of stromal niche (Review)". International Journal of Oncology 44, no. 2 (2014): 364-370. https://doi.org/10.3892/ijo.2013.2201
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