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Article Open Access

GLI1 upregulates C-JUN through a specific 130-kDa isoform

  • Authors:
    • Lauren Amable
    • Elaine Gavin
    • Kenji Kudo
    • Erhong Meng
    • Rodney P. Rocconi
    • Lalita A. Shevde
    • Eddie Reed
  • View Affiliations / Copyright

    Affiliations: National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD 20892, USA, Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA, Department of Pathology, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Copyright: © Amable et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 655-661
    |
    Published online on: December 20, 2013
       https://doi.org/10.3892/ijo.2013.2222
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Abstract

The Hedgehog pathway is molecularly linked to increased resistance to cisplatin and increased repair of platinum-DNA damage, through C-JUN. GLI1, which has five known isoforms, is a positive transcriptional regulator in Hedgehog. Southwestern blot assay, EMSA and ChIP assays indicate that only one of five isoforms of GLI1 may be responsible for the Hedgehog link with C-JUN and thus, increased platinum-DNA adduct repair. Cancer tissues express this 130-kDa isoform at levels 6-fold higher than non-malignant tissues; and this isoform exists in abundance in six of seven ovarian cancer cell lines examined.
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Copy and paste a formatted citation
Spandidos Publications style
Amable L, Gavin E, Kudo K, Meng E, Rocconi RP, Shevde LA and Reed E: GLI1 upregulates C-JUN through a specific 130-kDa isoform. Int J Oncol 44: 655-661, 2014.
APA
Amable, L., Gavin, E., Kudo, K., Meng, E., Rocconi, R.P., Shevde, L.A., & Reed, E. (2014). GLI1 upregulates C-JUN through a specific 130-kDa isoform. International Journal of Oncology, 44, 655-661. https://doi.org/10.3892/ijo.2013.2222
MLA
Amable, L., Gavin, E., Kudo, K., Meng, E., Rocconi, R. P., Shevde, L. A., Reed, E."GLI1 upregulates C-JUN through a specific 130-kDa isoform". International Journal of Oncology 44.3 (2014): 655-661.
Chicago
Amable, L., Gavin, E., Kudo, K., Meng, E., Rocconi, R. P., Shevde, L. A., Reed, E."GLI1 upregulates C-JUN through a specific 130-kDa isoform". International Journal of Oncology 44, no. 3 (2014): 655-661. https://doi.org/10.3892/ijo.2013.2222
Copy and paste a formatted citation
x
Spandidos Publications style
Amable L, Gavin E, Kudo K, Meng E, Rocconi RP, Shevde LA and Reed E: GLI1 upregulates C-JUN through a specific 130-kDa isoform. Int J Oncol 44: 655-661, 2014.
APA
Amable, L., Gavin, E., Kudo, K., Meng, E., Rocconi, R.P., Shevde, L.A., & Reed, E. (2014). GLI1 upregulates C-JUN through a specific 130-kDa isoform. International Journal of Oncology, 44, 655-661. https://doi.org/10.3892/ijo.2013.2222
MLA
Amable, L., Gavin, E., Kudo, K., Meng, E., Rocconi, R. P., Shevde, L. A., Reed, E."GLI1 upregulates C-JUN through a specific 130-kDa isoform". International Journal of Oncology 44.3 (2014): 655-661.
Chicago
Amable, L., Gavin, E., Kudo, K., Meng, E., Rocconi, R. P., Shevde, L. A., Reed, E."GLI1 upregulates C-JUN through a specific 130-kDa isoform". International Journal of Oncology 44, no. 3 (2014): 655-661. https://doi.org/10.3892/ijo.2013.2222
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