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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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2014-March Volume 44 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Cholesterol induces autophagic and apoptotic death in gastric carcinoma cells

  • Authors:
    • Sung-Chul Lim
    • Keshab Raj Parajuli
    • Hong-Quan Duong
    • Jeong Eun Choi
    • Song Iy Han
  • View Affiliations / Copyright

    Affiliations: Research Center for Resistant Cells, College of Medicine, Chosun Universtity, Gwangju 501-759, Republic of Korea
  • Pages: 805-811
    |
    Published online on: January 7, 2014
       https://doi.org/10.3892/ijo.2014.2246
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Abstract

Despite conflicting results, there is evidence to suggest an inverse link between total body cholesterol levels and the risk of certain malignancies. Based on previous reports, this phenomenon appears to vary with cancer site, and, in particular, more consistent data on inverse relations was reported in the risk of gastric cancer. In the current study, the effect of cholesterol on gastric cancer cell viability was examined using an in vitro cell culture system. Addition of cholesterol in culture medium resulted in reduced viability and clonogenicity of SNU601, SNU638 and SNU216 gastric cancer cells by induction of both autophagic and apoptotic death. Transient inactivation of ERK1/2 was linked to reduction of cholesterol-mediated cell viability, and tumor necrosis factor‑related apoptosis-inducing ligand receptor 2 (TRAIL‑R2/DR5) was also involved in cell death signaling. In conclusion, these results imply that cholesterol can act as a signal regulator to modulate cell viability and that proper cellular cholesterol levels may be advantageous to suppress growth of gastric carcinomas.
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Copy and paste a formatted citation
Spandidos Publications style
Lim S, Parajuli KR, Duong H, Choi JE and Han SI: Cholesterol induces autophagic and apoptotic death in gastric carcinoma cells. Int J Oncol 44: 805-811, 2014.
APA
Lim, S., Parajuli, K.R., Duong, H., Choi, J.E., & Han, S.I. (2014). Cholesterol induces autophagic and apoptotic death in gastric carcinoma cells. International Journal of Oncology, 44, 805-811. https://doi.org/10.3892/ijo.2014.2246
MLA
Lim, S., Parajuli, K. R., Duong, H., Choi, J. E., Han, S. I."Cholesterol induces autophagic and apoptotic death in gastric carcinoma cells". International Journal of Oncology 44.3 (2014): 805-811.
Chicago
Lim, S., Parajuli, K. R., Duong, H., Choi, J. E., Han, S. I."Cholesterol induces autophagic and apoptotic death in gastric carcinoma cells". International Journal of Oncology 44, no. 3 (2014): 805-811. https://doi.org/10.3892/ijo.2014.2246
Copy and paste a formatted citation
x
Spandidos Publications style
Lim S, Parajuli KR, Duong H, Choi JE and Han SI: Cholesterol induces autophagic and apoptotic death in gastric carcinoma cells. Int J Oncol 44: 805-811, 2014.
APA
Lim, S., Parajuli, K.R., Duong, H., Choi, J.E., & Han, S.I. (2014). Cholesterol induces autophagic and apoptotic death in gastric carcinoma cells. International Journal of Oncology, 44, 805-811. https://doi.org/10.3892/ijo.2014.2246
MLA
Lim, S., Parajuli, K. R., Duong, H., Choi, J. E., Han, S. I."Cholesterol induces autophagic and apoptotic death in gastric carcinoma cells". International Journal of Oncology 44.3 (2014): 805-811.
Chicago
Lim, S., Parajuli, K. R., Duong, H., Choi, J. E., Han, S. I."Cholesterol induces autophagic and apoptotic death in gastric carcinoma cells". International Journal of Oncology 44, no. 3 (2014): 805-811. https://doi.org/10.3892/ijo.2014.2246
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