Cholesterol induces autophagic and apoptotic death in gastric carcinoma cells

  • Authors:
    • Sung-Chul Lim
    • Keshab Raj Parajuli
    • Hong-Quan Duong
    • Jeong Eun Choi
    • Song Iy Han
  • View Affiliations

  • Published online on: January 7, 2014     https://doi.org/10.3892/ijo.2014.2246
  • Pages: 805-811
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Abstract

Despite conflicting results, there is evidence to suggest an inverse link between total body cholesterol levels and the risk of certain malignancies. Based on previous reports, this phenomenon appears to vary with cancer site, and, in particular, more consistent data on inverse relations was reported in the risk of gastric cancer. In the current study, the effect of cholesterol on gastric cancer cell viability was examined using an in vitro cell culture system. Addition of cholesterol in culture medium resulted in reduced viability and clonogenicity of SNU601, SNU638 and SNU216 gastric cancer cells by induction of both autophagic and apoptotic death. Transient inactivation of ERK1/2 was linked to reduction of cholesterol-mediated cell viability, and tumor necrosis factor‑related apoptosis-inducing ligand receptor 2 (TRAIL‑R2/DR5) was also involved in cell death signaling. In conclusion, these results imply that cholesterol can act as a signal regulator to modulate cell viability and that proper cellular cholesterol levels may be advantageous to suppress growth of gastric carcinomas.
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2014-March
Volume 44 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Lim S, Parajuli KR, Duong H, Choi JE and Han SI: Cholesterol induces autophagic and apoptotic death in gastric carcinoma cells. Int J Oncol 44: 805-811, 2014
APA
Lim, S., Parajuli, K.R., Duong, H., Choi, J.E., & Han, S.I. (2014). Cholesterol induces autophagic and apoptotic death in gastric carcinoma cells. International Journal of Oncology, 44, 805-811. https://doi.org/10.3892/ijo.2014.2246
MLA
Lim, S., Parajuli, K. R., Duong, H., Choi, J. E., Han, S. I."Cholesterol induces autophagic and apoptotic death in gastric carcinoma cells". International Journal of Oncology 44.3 (2014): 805-811.
Chicago
Lim, S., Parajuli, K. R., Duong, H., Choi, J. E., Han, S. I."Cholesterol induces autophagic and apoptotic death in gastric carcinoma cells". International Journal of Oncology 44, no. 3 (2014): 805-811. https://doi.org/10.3892/ijo.2014.2246