MicroRNA-26a acts as a tumor suppressor inhibiting gallbladder cancer cell proliferation by directly targeting HMGA2

Zhou,Huading; Guo,Weijie; Zhao,Yingjun; Wang,Yifei; Zha,Ruopeng; Ding,Jie; Liang,Linhui; Hu,Jun; Shen,Hao; Chen,Zongyou; Yin,Baobing; Ma,Baojin

doi:10.3892/ijo.2014.2360

June-2014 Volume 44 Issue 6

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June-2014 Volume 44 Issue 6

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Article

MicroRNA-26a acts as a tumor suppressor inhibiting gallbladder cancer cell proliferation by directly targeting HMGA2

Authors:
- Huading Zhou
- Weijie Guo
- Yingjun Zhao
- Yifei Wang
- Ruopeng Zha
- Jie Ding
- Linhui Liang
- Jun Hu
- Hao Shen
- Zongyou Chen
- Baobing Yin
- Baojin Ma
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Affiliations: Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiao Tong University, School of Medicine, Shanghai 200032, P.R. China, Jing'an District Center Hospital of Shanghai Huashan Hospital, Fudan University, Jing'an Branch, Shanghai 200040, P.R. China
Pages: 2050-2058
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Published online on: March 27, 2014

https://doi.org/10.3892/ijo.2014.2360
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Abstract

MicroRNAs (miRNAs) are a class of small, single-stranded, non-coding RNA molecules which can act as oncogenes or tumor suppressor genes in human cancer. However, the possible functions and mechanisms of miRNA action in gallbladder cancer (GBC) have not been elucidated. In the present study, it was found that miR-26a was often downregulated in GBC and the expression of miR-26a was associated with neoplasm histological grade. miR-26a significantly inhibited the proliferation of GBC cells based on the gain-of-function assays. Furthermore, we demonstrated that high mobility group AT-hook 2 (HMGA2) was a direct target of miR-26a. The results showed that HMGA2 mRNA levels and miR-26a levels were negatively correlated. In addition, we confirmed that reintroduction of HMGA2 antagonized the inhibition of miR-26a to GBC cell proliferation and all these effects were achieved through the cell cycle. Together, all these results suggest that miR-26a expression contributes to GBC proliferation by targeting HMGA2. miR-26a shows promise as a prognosis factor and therapeutic target of GBC patients.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

MicroRNA-26a acts as a tumor suppressor inhibiting gallbladder cancer cell proliferation by directly targeting HMGA2

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