Cancer stem cells and tumor metastasis (Review)

Li,Shuang; Li,Qin

doi:10.3892/ijo.2014.2362

Cancer stem cells and tumor metastasis (Review)

Authors:
- Shuang Li
- Qin Li
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Affiliations: The Southern Medical University, Guangzhou, P.R. China, Department of Plastic and Reconstructive Surgery, General Hospital of Guangzhou Military Command, Guangzhou, P.R. China
Published online on: April 2, 2014 https://doi.org/10.3892/ijo.2014.2362
Pages: 1806-1812
Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

Previous studies have shown that tumors can induce angiogenesis and lymphangiogenesis, which plays an important role in promoting hematogenous and lymphogenous spread. In recent years, the cancer stem cell (CSC) theory has emerged as an attractive hypothesis for tumor development and progression. The theory proposes that one small subset of cancer cells has the characteristics of stem cells. These CSCs have the capability of both self-renewal and differentiation into diverse cancer cells, which play a decisive role in maintaining capacity for malignant proliferation, invasion, metastasis, and tumor recurrence. CSCs are involved in tumor metastasis, however, the details, and the possible relationship of CSCs, angiogenesis, lymphangiogenesis, and tumor metastasis is still ambiguous. The aim of this report is to summarize current studies of CSCs and tumor metastasis at the cellular level, with the goal of bringing new insights into understanding the role of CSCs in tumor metastasis.

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