Factors associated with dropout in a lung cancer high‑risk cohort - the Liverpool lung project

Marcus,Michael W.; Raji,Olaide Y.; Chen,Ying; Duffy,Stephen W.; Field,John K.

doi:10.3892/ijo.2014.2371

June-2014 Volume 44 Issue 6

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June-2014 Volume 44 Issue 6

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Article

Factors associated with dropout in a lung cancer high‑risk cohort - the Liverpool lung project

Authors:
- Michael W. Marcus
- Olaide Y. Raji
- Ying Chen
- Stephen W. Duffy
- John K. Field
View Affiliations / Copyright

Affiliations: Roy Castle Lung Cancer Research Programme, The University of Liverpool Cancer Research Centre, Institute of Translational Medicine, The University of Liverpool, Liverpool L3 9TA, UK, Wolfson Institute of Preventive Medicine, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK
Pages: 2146-2152
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Published online on: April 7, 2014

https://doi.org/10.3892/ijo.2014.2371
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Abstract

In long-term longitudinal cohort studies the dropout of participants occurring as a result of withdrawal or lost to follow-up may have greater impact on the effect estimates, if characteristics of participants who drop out and those still active in the study differ significantly. The study aimed to investigate factors associated with dropout in a 5-year follow-up of individuals at ‘high‑risk’ of lung cancer. We studied ‘high‑risk’ group of 1,486 individuals aged 45-79 selected from the Liverpool Lung Prospective (LLP) cohort study using a strategy reflecting only age, smoking duration and history of pulmonary disease. Study subjects were recalled annually from 2005-2009 for follow-up collection of specimens and questionnaire data. The dropout rate over the follow-up time was investigated using the Kaplan‑Meier survival curve and the Cox proportional hazard model. Dropout rate was 31% after an average of 3 annual visits. Female gender hazard ratio (HR) 1.35 (95% CI 1.09-1.66), current smoking 1.26 (1.02-1.57), prior diagnosis of malignant disease 0.54 (0.36-0.79), home visits 0.67 (0.48-0.94) and systolic blood pressure 1.46 (1.10-1.94) were significantly associated with the dropout rate. Nearly 40% of individuals selected into the ‘high‑risk’ group by the old criteria were low risk with predicted 5-year absolute risk of less than 2.5%. In conclusion, follow-up of individuals is feasible within the LLP, but may be prone to selective withdrawal attributable to patient's state of health and mobility. We recommend future design of ‘high‑risk’ follow‑up studies to consider home visit as a useful strategy to encourage continued participation.

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1.	Vandenbroucke JP: Observational research, randomised trials, and two views of medical science. PLoS Med. 5:e672008. View Article : Google Scholar : PubMed/NCBI
2.	Rothman KJ and Greenland S: Cohort studies. Rothman KJ, Greenland S and Lash TL: Modern Epidemiology. 3rd edition. Lippincott Williams & Wilkins; Philadelphia, PA: pp. 100–110. 2008
3.	Pirie PL, Thomson SJ, Mann SL, et al: Tracking and attrition in longitudinal school-based smoking prevention research. Prev Med. 18:249–256. 1989. View Article : Google Scholar : PubMed/NCBI
4.	Guey LT, Bromet EJ, Gluzman SF, Zakhozha V and Paniotto V: Determinants of participation in a longitudinal two-stage study of the health consequences of the Chornobyl nuclear power plant accident. BMC Med Res Methodol. 8:272008. View Article : Google Scholar : PubMed/NCBI
5.	Oleske DM, Kwasny MM, Lavender SA and Andersson GB: Participation in occupational health longitudinal studies: predictors of missed visits and dropouts. Ann Epidemiol. 17:9–18. 2007. View Article : Google Scholar : PubMed/NCBI
6.	Van Beijsterveldt CE, van Boxtel MP, Bosma H, Houx PJ, Buntinx F and Jolles J: Predictors of attrition in a longitudinal cognitive aging study: the Maastricht Aging Study (MAAS). J Clin Epidemiol. 55:216–223. 2002.PubMed/NCBI
7.	Chatfield MD, Brayne CE and Matthews FE: A systematic literature review of attrition between waves in longitudinal studies in the elderly shows a consistent pattern of dropout between differing studies. J Clin Epidemiol. 58:13–19. 2005. View Article : Google Scholar
8.	Phillips KA, Butow PN, Stewart AE, et al: Predictors of participation in clinical and psychosocial follow-up of the kConFab breast cancer family cohort. Fam Cancer. 4:105–113. 2005. View Article : Google Scholar : PubMed/NCBI
9.	Field JK, Smith DL, Duffy S and Cassidy A: The Liverpool Lung Project research protocol. Int J Oncol. 27:1633–1645. 2005.PubMed/NCBI
10.	Cassidy A, Myles JP, Liloglou T, Duffy SW and Field JK: Defining high-risk individuals in a population-based molecular-epidemiological study of lung cancer. Int J Oncol. 28:1295–1301. 2006.PubMed/NCBI
11.	Cassidy A, Myles JP, van Tongeren M, Page RD, Liloglou T, Duffy SW and Field JK: The LLP risk model: an individual risk prediction model for lung cancer. Br J Cancer. 98:270–276. 2008. View Article : Google Scholar : PubMed/NCBI
12.	Spitz MR, Hong WK, Amos CI, et al: A risk model for prediction of lung cancer. J Natl Cancer Inst. 99:715–726. 2007. View Article : Google Scholar : PubMed/NCBI
13.	Singer JD and Willett JB: It’s about time: Using Discrete-Time Survival Analysis to study duration and the timing of events. J Educ Stat. 18:155–195. 1993.
14.	Willett JB and Singer JD: Investigating onset, cessation, relapse, and recovery: why you should, and how you can, use discrete-time survival analysis to examine event occurrence. J Consult Clin Psychol. 61:952–965. 1993. View Article : Google Scholar : PubMed/NCBI
15.	Bildt C, Alfredsson L, Punnett L, Theobald H, Torgen M and Wikman A: Effects of drop out in a longitudinal study of musculoskeletal disorders. Occup Environ Med. 58:194–199. 2001. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Factors associated with dropout in a lung cancer high‑risk cohort - the Liverpool lung project

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