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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June-2014 Volume 44 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Molecular targeting of neuroblastoma with a novel p16INK4a transporter system

  • Authors:
    • Takuya Kawaguchi
    • Kazuhiro Yoshikawa
    • Keiji Kawamoto
    • Kunikazu Yoshimura
    • Hideyuki Oshige
    • Akio Asai
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Kansai Medical University, Moriguchi City, Osaka 570-8507, Japan, Second Department of Pathology, Aichi Medical University School of Medicine, Yazago, Nagakute City, Aichi 480-1195, Japan, Higashi Oosakayamaji Hospital, Higashiosaka City, Osaka 578-0925, Japan, Department of Neurosurgery, Kansai Medical University, Hirakata City, Osaka 573-1191, Japan
  • Pages: 1879-1885
    |
    Published online on: April 7, 2014
       https://doi.org/10.3892/ijo.2014.2372
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Abstract

Potential molecular targets in neuroblastoma include ALK mutations, p16 deletion and CDK2A mutations; however, targeted therapeutics have not been developed for these factors. We developed Wr-T, a new system for intracellular peptide and protein delivery with a 30-residue sequence that mediates molecule entrapment and intracellular permeability. Wr-T was used to introduce the p16INK4a functional peptide to restore the tumor suppressor function of p16INK4a. Introduction of Wr-T into rats with subcutaneous grafts of neuroblastoma produced an astonishing 75.6% tumor suppression (p<0.0005). Thus, the p16INK4a functional peptide can be introduced in low doses and, because it exists in vivo, it should produce fewer side-effects than standard chemotherapy. We suggest this system could be used for molecular-targeted peptides other than p16INK4a and should be pursued for further development.
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Copy and paste a formatted citation
Spandidos Publications style
Kawaguchi T, Yoshikawa K, Kawamoto K, Yoshimura K, Oshige H and Asai A: Molecular targeting of neuroblastoma with a novel p16INK4a transporter system. Int J Oncol 44: 1879-1885, 2014.
APA
Kawaguchi, T., Yoshikawa, K., Kawamoto, K., Yoshimura, K., Oshige, H., & Asai, A. (2014). Molecular targeting of neuroblastoma with a novel p16INK4a transporter system. International Journal of Oncology, 44, 1879-1885. https://doi.org/10.3892/ijo.2014.2372
MLA
Kawaguchi, T., Yoshikawa, K., Kawamoto, K., Yoshimura, K., Oshige, H., Asai, A."Molecular targeting of neuroblastoma with a novel p16INK4a transporter system". International Journal of Oncology 44.6 (2014): 1879-1885.
Chicago
Kawaguchi, T., Yoshikawa, K., Kawamoto, K., Yoshimura, K., Oshige, H., Asai, A."Molecular targeting of neuroblastoma with a novel p16INK4a transporter system". International Journal of Oncology 44, no. 6 (2014): 1879-1885. https://doi.org/10.3892/ijo.2014.2372
Copy and paste a formatted citation
x
Spandidos Publications style
Kawaguchi T, Yoshikawa K, Kawamoto K, Yoshimura K, Oshige H and Asai A: Molecular targeting of neuroblastoma with a novel p16INK4a transporter system. Int J Oncol 44: 1879-1885, 2014.
APA
Kawaguchi, T., Yoshikawa, K., Kawamoto, K., Yoshimura, K., Oshige, H., & Asai, A. (2014). Molecular targeting of neuroblastoma with a novel p16INK4a transporter system. International Journal of Oncology, 44, 1879-1885. https://doi.org/10.3892/ijo.2014.2372
MLA
Kawaguchi, T., Yoshikawa, K., Kawamoto, K., Yoshimura, K., Oshige, H., Asai, A."Molecular targeting of neuroblastoma with a novel p16INK4a transporter system". International Journal of Oncology 44.6 (2014): 1879-1885.
Chicago
Kawaguchi, T., Yoshikawa, K., Kawamoto, K., Yoshimura, K., Oshige, H., Asai, A."Molecular targeting of neuroblastoma with a novel p16INK4a transporter system". International Journal of Oncology 44, no. 6 (2014): 1879-1885. https://doi.org/10.3892/ijo.2014.2372
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