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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June-2014 Volume 44 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

The expression and phosphorylation of ezrin and merlin in human pancreatic cancer

  • Authors:
    • Jiahua Zhou
    • Yongjiang Feng
    • Ketao Tao
    • Zhanhai Su
    • Xiaojin Yu
    • Jie Zheng
    • Lihua Zhang
    • Detong Yang
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, P.R. China, Basic Medical Research Center, Qinghai University, Xining 810001, P.R. China, Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing 210009, P.R. China, Department of Pathology, School of Medicine, Southeast University, Nanjing 210009, P.R. China, Department of Surgical Pathology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, P.R. China
  • Pages: 2059-2067
    |
    Published online on: April 10, 2014
       https://doi.org/10.3892/ijo.2014.2381
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Abstract

Pancreatic carcinoma is the most common pancreatic malignancy and is associated with a very poor prognosis. Therefore, new prognostic factors and new treatment strategies are clearly needed. In this study, we retrospectively studied the levels of phosphorylated ezrin in 19 patients with pancreatic carcinoma by immunohistochemical analysis and determined the correlation between protein expression, clinicopathological characteristics and prognosis in pancreatic adenocarcinoma. We also characterized the phenotype of the overexpression of wild-type and phosphorylated ezrin and merlin in human pancreatic cancer cell lines. A significant correlation between the levels of phosphorylated ezrin 353 and ezrin 567 and the stage of pancreatic cancer was observed. Moreover, Kaplan-Meier analysis revealed that patients with high levels of phosphorylated ezrin had a significantly poorer survival rate (P<0.05). In addition, the overexpression of wild-type merlin or ezrin inhibited cell proliferation, migration and adhesion. However, the overexpression of T567D ezrin, a mutant that mimics permanent phosphorylation, promoted the proliferation, adhesion and migration of the pancreatic adenocarcinoma cell line SW1990. The overexpression of S518D merlin inhibited the growth of SW1990 and did not affect migration or adhesion. These results suggest that the phosphorylation of ezrin may contribute to the progression of pancreatic carcinoma and that the level of phosphorylated ezrin may serve as an adverse prognostic factor for pancreatic carcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou J, Feng Y, Tao K, Su Z, Yu X, Zheng J, Zhang L and Yang D: The expression and phosphorylation of ezrin and merlin in human pancreatic cancer. Int J Oncol 44: 2059-2067, 2014.
APA
Zhou, J., Feng, Y., Tao, K., Su, Z., Yu, X., Zheng, J. ... Yang, D. (2014). The expression and phosphorylation of ezrin and merlin in human pancreatic cancer. International Journal of Oncology, 44, 2059-2067. https://doi.org/10.3892/ijo.2014.2381
MLA
Zhou, J., Feng, Y., Tao, K., Su, Z., Yu, X., Zheng, J., Zhang, L., Yang, D."The expression and phosphorylation of ezrin and merlin in human pancreatic cancer". International Journal of Oncology 44.6 (2014): 2059-2067.
Chicago
Zhou, J., Feng, Y., Tao, K., Su, Z., Yu, X., Zheng, J., Zhang, L., Yang, D."The expression and phosphorylation of ezrin and merlin in human pancreatic cancer". International Journal of Oncology 44, no. 6 (2014): 2059-2067. https://doi.org/10.3892/ijo.2014.2381
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou J, Feng Y, Tao K, Su Z, Yu X, Zheng J, Zhang L and Yang D: The expression and phosphorylation of ezrin and merlin in human pancreatic cancer. Int J Oncol 44: 2059-2067, 2014.
APA
Zhou, J., Feng, Y., Tao, K., Su, Z., Yu, X., Zheng, J. ... Yang, D. (2014). The expression and phosphorylation of ezrin and merlin in human pancreatic cancer. International Journal of Oncology, 44, 2059-2067. https://doi.org/10.3892/ijo.2014.2381
MLA
Zhou, J., Feng, Y., Tao, K., Su, Z., Yu, X., Zheng, J., Zhang, L., Yang, D."The expression and phosphorylation of ezrin and merlin in human pancreatic cancer". International Journal of Oncology 44.6 (2014): 2059-2067.
Chicago
Zhou, J., Feng, Y., Tao, K., Su, Z., Yu, X., Zheng, J., Zhang, L., Yang, D."The expression and phosphorylation of ezrin and merlin in human pancreatic cancer". International Journal of Oncology 44, no. 6 (2014): 2059-2067. https://doi.org/10.3892/ijo.2014.2381
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