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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June-2014 Volume 44 Issue 6

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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

Gene expression signatures for identifying diffuse-type gastric cancer associated with epithelial-mesenchymal transition

  • Authors:
    • Shihori Tanabe
    • Kazuhiko Aoyagi
    • Hiroshi Yokozaki
    • Hiroki Sasaki
  • View Affiliations / Copyright

    Affiliations: Division of Safety Information on Drug, Food and Chemicals, National Institute of Health Sciences, Setagaya-ku, Tokyo 158-8501, Japan, Department of Translational Oncology, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan, Department of Pathology, Kobe University Graduate School of Medicine, Chuo-ku, Kobe 650-0017, Japan
  • Pages: 1955-1970
    |
    Published online on: April 11, 2014
       https://doi.org/10.3892/ijo.2014.2387
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Abstract

Epithelial-mesenchymal transition (EMT) is associated with tumor malignancy. The hedgehog-EMT pathway is preferentially activated in diffuse-type gastric cancer (GC) compared with intestinal-type GC; however, histological typing is currently the only method for distinguishing these two major types of GC. We compared the gene expression profiles of 12 bone marrow-derived mesenchymal stem cell cultures and 5 diffuse-type GC tissue samples. Numerous upregulated or downregulated genes were identified in diffuse-type GC, including CDH1, CDH2, VIM, WNT4 and WNT5. Among these genes, the mRNA ratio of CDH2 to CDH1 could distinguish the 15 diffuse-type GC samples from the 17 intestinal-type GC samples. Our results suggested that the mesenchymal features were more prominent in diffuse-type GC than in intestinal-type GC, but were weaker in diffuse-type GC than in mesenchymal stem cells. Diffuse-type GC that has undergone extensive EMT, which has a poor prognosis, can be identified by quantitative PCR analysis of only two genes.
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Copy and paste a formatted citation
Spandidos Publications style
Tanabe S, Aoyagi K, Yokozaki H and Sasaki H: Gene expression signatures for identifying diffuse-type gastric cancer associated with epithelial-mesenchymal transition. Int J Oncol 44: 1955-1970, 2014.
APA
Tanabe, S., Aoyagi, K., Yokozaki, H., & Sasaki, H. (2014). Gene expression signatures for identifying diffuse-type gastric cancer associated with epithelial-mesenchymal transition. International Journal of Oncology, 44, 1955-1970. https://doi.org/10.3892/ijo.2014.2387
MLA
Tanabe, S., Aoyagi, K., Yokozaki, H., Sasaki, H."Gene expression signatures for identifying diffuse-type gastric cancer associated with epithelial-mesenchymal transition". International Journal of Oncology 44.6 (2014): 1955-1970.
Chicago
Tanabe, S., Aoyagi, K., Yokozaki, H., Sasaki, H."Gene expression signatures for identifying diffuse-type gastric cancer associated with epithelial-mesenchymal transition". International Journal of Oncology 44, no. 6 (2014): 1955-1970. https://doi.org/10.3892/ijo.2014.2387
Copy and paste a formatted citation
x
Spandidos Publications style
Tanabe S, Aoyagi K, Yokozaki H and Sasaki H: Gene expression signatures for identifying diffuse-type gastric cancer associated with epithelial-mesenchymal transition. Int J Oncol 44: 1955-1970, 2014.
APA
Tanabe, S., Aoyagi, K., Yokozaki, H., & Sasaki, H. (2014). Gene expression signatures for identifying diffuse-type gastric cancer associated with epithelial-mesenchymal transition. International Journal of Oncology, 44, 1955-1970. https://doi.org/10.3892/ijo.2014.2387
MLA
Tanabe, S., Aoyagi, K., Yokozaki, H., Sasaki, H."Gene expression signatures for identifying diffuse-type gastric cancer associated with epithelial-mesenchymal transition". International Journal of Oncology 44.6 (2014): 1955-1970.
Chicago
Tanabe, S., Aoyagi, K., Yokozaki, H., Sasaki, H."Gene expression signatures for identifying diffuse-type gastric cancer associated with epithelial-mesenchymal transition". International Journal of Oncology 44, no. 6 (2014): 1955-1970. https://doi.org/10.3892/ijo.2014.2387
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