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Review

The unique protein kinase Cη: Implications for breast cancer (Review)

  • Authors:
    • Deepanwita Pal
    • Alakananda Basu
  • View Affiliations / Copyright

    Affiliations: Department of Molecular and Medical Genetics, University of North Texas Health Science Center and Institute for Cancer Research, Fort Worth, TX 76107, USA
  • Pages: 493-498
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    Published online on: May 19, 2014
       https://doi.org/10.3892/ijo.2014.2443
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Abstract

Deregulation of key signal transduction pathways that govern important cellular processes leads to cancer. The development of effective therapeutics for cancer warrants a comprehensive understanding of the signaling pathways that are deregulated in cancer. The protein kinase C (PKC) family has served as an attractive target for cancer therapy for decades owing to its crucial roles in several cellular processes. PKCη is a novel member of the PKC family that plays critical roles in various cellular processes such as growth, proliferation, differentiation and cell death. The regulation of PKCη appears to be unique compared to other PKC isozymes, and there are conflicting reports regarding its role in cancer. This review focuses on the unique aspects of PKCη in terms of its structure, regulation and subcellular distribution and speculates on how these features could account for its distinct functions. We have also discussed the functional implications of PKCη in cancer with particular emphasis on breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Pal D and Basu A: The unique protein kinase Cη: Implications for breast cancer (Review). Int J Oncol 45: 493-498, 2014.
APA
Pal, D., & Basu, A. (2014). The unique protein kinase Cη: Implications for breast cancer (Review). International Journal of Oncology, 45, 493-498. https://doi.org/10.3892/ijo.2014.2443
MLA
Pal, D., Basu, A."The unique protein kinase Cη: Implications for breast cancer (Review)". International Journal of Oncology 45.2 (2014): 493-498.
Chicago
Pal, D., Basu, A."The unique protein kinase Cη: Implications for breast cancer (Review)". International Journal of Oncology 45, no. 2 (2014): 493-498. https://doi.org/10.3892/ijo.2014.2443
Copy and paste a formatted citation
x
Spandidos Publications style
Pal D and Basu A: The unique protein kinase Cη: Implications for breast cancer (Review). Int J Oncol 45: 493-498, 2014.
APA
Pal, D., & Basu, A. (2014). The unique protein kinase Cη: Implications for breast cancer (Review). International Journal of Oncology, 45, 493-498. https://doi.org/10.3892/ijo.2014.2443
MLA
Pal, D., Basu, A."The unique protein kinase Cη: Implications for breast cancer (Review)". International Journal of Oncology 45.2 (2014): 493-498.
Chicago
Pal, D., Basu, A."The unique protein kinase Cη: Implications for breast cancer (Review)". International Journal of Oncology 45, no. 2 (2014): 493-498. https://doi.org/10.3892/ijo.2014.2443
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