|
1
|
Siegel R, Naishadham D and Jemal A: Cancer
statistics, 2013. CA Cancer J Clin. 63:11–30. 2013. View Article : Google Scholar
|
|
2
|
Ribeiro JT, Macedo LT, Curigliano G, et
al: Cytotoxic drugs for patients with breast cancer in the era of
targeted treatment: back to the future? Ann Oncol. 23:547–555.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Karikas GA: Anticancer and chemopreventing
natural products: some biochemical and therapeutic aspects. J BUON.
15:627–638. 2010.PubMed/NCBI
|
|
4
|
Cragg GM and Newman DJ: Natural products:
a continuing source of novel drug leads. Biochim Biophys Acta.
6:182013.
|
|
5
|
Wang TH, Wang HS and Soong YK:
Paclitaxel-induced cell death: Where the cell cycle and apoptosis
come together. Cancer. 88:2619–2628. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Ding Q, Yang LX, Yang HW, Jiang C, Wang YF
and Wang S: Cytotoxic and antibacterial triterpenoids derivatives
from Clematis ganpiniana. J Ethnopharmacol. 126:382–385.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Podolak I, Galanty A and Sobolewska D:
Saponins as cytotoxic agents: a review. Phytochem Rev. 9:425–474.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Augustin JM, Kuzina V, Andersen SB and Bak
S: Molecular activities, biosynthesis and evolution of triterpenoid
saponins. Phytochemistry. 72:435–457. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Bishayee A, Ahmed S, Brankov N and Perloff
M: Triterpenoids as potential agents for the chemoprevention and
therapy of breast cancer. Front Biosci (Landmark Ed). 16:980–996.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Patlolla JMR and Rao CV: Triterpenoids for
cancer prevention and treatment: Current status and future
prospects. Curr Pharm Biotechnol. 13:147–155. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Calabrese AI: Letter: Antiviral activity
of hederin. J Pharm Sci. 64:VIII1975. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Gepdiremen A, Mshvildadze V, Suleyman H
and Elias R: Acute anti-inflammatory activity of four saponins
isolated from ivy: alpha-hederin, hederasaponin-C,
hederacolchiside-E and hederacolchiside-F in carrageenan-induced
rat paw edema. Phytomedicine. 12:440–444. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Gulcin I, Mshvildadze V, Gepdiremen A and
Elias R: Antioxidant activity of saponins isolated from ivy:
alpha-hederin, hederasaponin-C, hederacolchiside-E and
hederacolchiside-F. Planta Med. 70:561–563. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Ridoux O, Di Giorgio C, Delmas F, et al:
In vitro antileishmanial activity of three saponins isolated from
ivy, alpha-hederin, beta-hederin and hederacolchiside A(1), in
association with pentamidine and amphotericin B. Phytother Res.
15:298–301. 2001. View
Article : Google Scholar : PubMed/NCBI
|
|
15
|
Trute A, Gross J, Mutschler E and
Nahrstedt A: In vitro antispasmodic compounds of the dry extract
obtained from Hedera helix. Planta Med. 63:125–129. 1997.
View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Quetin-Leclercq J, Elias R, Balansard G,
Bassleer R and Angenot L: Cytotoxic activity of some triterpenoid
saponins. Planta Med. 58:279–281. 1992. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Danloy S, Quetin-Leclercq J, Coucke P, et
al: Effects of alpha-hederin, a saponin extracted from Hedera
helix, on cells cultured in vitro. Planta Med. 60:45–49. 1994.
View Article : Google Scholar
|
|
18
|
Rooney S and Ryan MF: Effects of
alpha-hederin and thymoquinone, constituents of Nigella
sativa, on human cancer cell lines. Anticancer Res.
25:2199–2204. 2005.PubMed/NCBI
|
|
19
|
Tian Z, Liu YM, Chen SB, et al:
Cytotoxicity of two triterpenoids from Nigella glandulifera.
Molecules. 11:693–699. 2006. View
Article : Google Scholar : PubMed/NCBI
|
|
20
|
Yan LH, Xu LZ, Lin J, Yang SL and Feng YL:
Triterpenoid saponins from the stems of Clematis parviloba.
J Asian Nat Prod Res. 11:332–338. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Kumara SS and Huat BT: Extraction,
isolation and characterisation of antitumor principle,
alpha-hederin, from the seeds of Nigella sativa. Planta Med.
67:29–32. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Feller G, Kugel A, Moonshine D, et al:
African descents are more sensitive than European descents to the
antitumor compounds alpha-hederin and kalopanaxsaponin I. Planta
Med. 76:1847–1851. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Pasi S, Aligiannis N, Pratsinis H,
Skaltsounis AL and Chinou IB: Biologically active triterpenoids
from Cephalaria ambrosioides. Planta Med. 75:163–167. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Swamy SM and Huat BT: Intracellular
glutathione depletion and reactive oxygen species generation are
important in alpha-hederin-induced apoptosis of P388 cells. Mol
Cell Biochem. 245:127–139. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Rooney S and Ryan MF: Modes of action of
alpha-hederin and thymoquinone, active constituents of Nigella
sativa, against HEp-2 cancer cells. Anticancer Res.
25:4255–4259. 2005.PubMed/NCBI
|
|
26
|
Liu JJ, Lin M, Yu JY, Liu B and Bao JK:
Targeting apoptotic and autophagic pathways for cancer
therapeutics. Cancer Lett. 300:105–114. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Shi Y: Mechanisms of caspase activation
and inhibition during apoptosis. Mol Cell. 9:459–470. 2002.
View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Dias N and Bailly C: Drugs targeting
mitochondrial functions to control tumor cell growth. Biochem
Pharmacol. 70:1–12. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Suen DF, Norris KL and Youle RJ:
Mitochondrial dynamics and apoptosis. Genes Dev. 22:1577–1590.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Wang QF, Chen JC, Hsieh SJ, Cheng CC and
Hsu SL: Regulation of Bcl-2 family molecules and activation of
caspase cascade involved in gypenosides-induced apoptosis in human
hepatoma cells. Cancer Lett. 183:169–178. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Wang J, Zhao XZ, Qi Q, et al:
Macranthoside B, a hederagenin saponin extracted from Lonicera
macranthoides and its anti-tumor activities in vitro and in
vivo. Food Chem Toxicol. 47:1716–1721. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Park HM, Kim SJ, Kim JS and Kang HS:
Reactive oxygen species mediated ginsenoside Rg3- and Rh2-induced
apoptosis in hepatoma cells through mitochondrial signaling
pathways. Food Chem Toxicol. 50:2736–2741. 2012. View Article : Google Scholar
|
|
33
|
Chun J, Ha IJ and Kim YS:
Antiproliferative and apoptotic activities of triterpenoid saponins
from the roots of Platycodon grandiflorum and their
structure-activity relationships. Planta Med. 79:639–645. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Mo S, Xiong H, Shu G, et al:
Phaseoloideside E, a novel natural triterpenoid saponin identified
from Entada phaseoloides, induces apoptosis in Ec-109
esophageal cancer cells through reactive oxygen species generation.
J Pharmacol Sci. 122:163–175. 2013.PubMed/NCBI
|
|
35
|
Wang CZ, Li XL, Wang QF, Mehendale SR,
Fishbein AB, Han AH, Sun S and Yuan CS: The mitochondrial pathway
is involved in American ginseng-induced apoptosis of SW-480 colon
cancer cells. Oncol Rep. 21:577–584. 2009.PubMed/NCBI
|
