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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August-2014 Volume 45 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Loss of ARHGDIA expression is associated with poor prognosis in HCC and promotes invasion and metastasis of HCC cells

  • Authors:
    • Lei Liang
    • Qian Li
    • Li Yong Huang
    • Da Wei Li
    • Yu Wei Wang
    • Xin Xiang Li
    • San Jun Cai
  • View Affiliations / Copyright

    Affiliations: Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China, Department of Anesthesiology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200032, P.R. China
  • Pages: 659-666
    |
    Published online on: May 21, 2014
       https://doi.org/10.3892/ijo.2014.2451
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Abstract

Rho GTPases control a wide range of cellu­lar processes and contribute to tumor invasion and metastasis. As a regulator of Rho activity, ARHGDIA is aberrantly expressed in several types of tumors and plays different roles in the tumor process. To elucidate the role of ARHGDIA in HCC, we investigated the patterns of its expression, prognosis and clinical profiles in HCC. Functional assays were performed to investigate whether the alteration of ARHGDIA has an effect on cell growth, migration and invasion, as well as the status of Rho GTPases. We found that ARHGDIA was frequently downregulated in HCC and associated with tumor invasion and metastasis. Moreover, ARHGDIA was significantly associated with OS and TTR of HCC patients. Low level of ARHGDIA exhibited a decreased postoperative OS and a shorter TTR compared those with high levels. Functional assays showed that loss of ARHGDIA promoted HCC cell migration and invasion in vitro and lung metastasis formation in vivo. We found that loss of ARHGDIA significantly induced Rac1 and RhoA activation which may contribute to invasion and metastasis of HCC. In conclusion, the present study has identified loss of ARHGDIA contributed to the processes of hepatic tumorigenesis, in particular invasion and metastasis which may provide a potential therapeutic target for HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Liang L, Li Q, Huang LY, Li DW, Wang YW, Li XX and Cai SJ: Loss of ARHGDIA expression is associated with poor prognosis in HCC and promotes invasion and metastasis of HCC cells. Int J Oncol 45: 659-666, 2014.
APA
Liang, L., Li, Q., Huang, L.Y., Li, D.W., Wang, Y.W., Li, X.X., & Cai, S.J. (2014). Loss of ARHGDIA expression is associated with poor prognosis in HCC and promotes invasion and metastasis of HCC cells. International Journal of Oncology, 45, 659-666. https://doi.org/10.3892/ijo.2014.2451
MLA
Liang, L., Li, Q., Huang, L. Y., Li, D. W., Wang, Y. W., Li, X. X., Cai, S. J."Loss of ARHGDIA expression is associated with poor prognosis in HCC and promotes invasion and metastasis of HCC cells". International Journal of Oncology 45.2 (2014): 659-666.
Chicago
Liang, L., Li, Q., Huang, L. Y., Li, D. W., Wang, Y. W., Li, X. X., Cai, S. J."Loss of ARHGDIA expression is associated with poor prognosis in HCC and promotes invasion and metastasis of HCC cells". International Journal of Oncology 45, no. 2 (2014): 659-666. https://doi.org/10.3892/ijo.2014.2451
Copy and paste a formatted citation
x
Spandidos Publications style
Liang L, Li Q, Huang LY, Li DW, Wang YW, Li XX and Cai SJ: Loss of ARHGDIA expression is associated with poor prognosis in HCC and promotes invasion and metastasis of HCC cells. Int J Oncol 45: 659-666, 2014.
APA
Liang, L., Li, Q., Huang, L.Y., Li, D.W., Wang, Y.W., Li, X.X., & Cai, S.J. (2014). Loss of ARHGDIA expression is associated with poor prognosis in HCC and promotes invasion and metastasis of HCC cells. International Journal of Oncology, 45, 659-666. https://doi.org/10.3892/ijo.2014.2451
MLA
Liang, L., Li, Q., Huang, L. Y., Li, D. W., Wang, Y. W., Li, X. X., Cai, S. J."Loss of ARHGDIA expression is associated with poor prognosis in HCC and promotes invasion and metastasis of HCC cells". International Journal of Oncology 45.2 (2014): 659-666.
Chicago
Liang, L., Li, Q., Huang, L. Y., Li, D. W., Wang, Y. W., Li, X. X., Cai, S. J."Loss of ARHGDIA expression is associated with poor prognosis in HCC and promotes invasion and metastasis of HCC cells". International Journal of Oncology 45, no. 2 (2014): 659-666. https://doi.org/10.3892/ijo.2014.2451
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