Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
August-2014 Volume 45 Issue 2

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2014 Volume 45 Issue 2

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Model to predict the survival benefit of radiation for patients with rhabdomyosarcoma after surgery: A population-based study

  • Authors:
    • Weidong Shen
    • Naoko Sakamoto
    • Limin Yang
  • View Affiliations / Copyright

    Affiliations: The Institute of Otolaryngology, Department of Otolaryngology, Head and Neck Surgery, Chinese PLA General Hospital, Beijing 100853, P.R. China, Department of Public Health, Juntendo University, Bunkyo-ku, Tokyo 113-8421, Japan, Epidemiology and Clinical Research Center for Children's Cancer, National Center for Child Health and Development, Tokyo 157-8535, Japan
  • Pages: 549-557
    |
    Published online on: May 26, 2014
       https://doi.org/10.3892/ijo.2014.2466
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of this study was to build a model to predict the survival benefit of radiotherapy for resected rhabdomyo­sarcoma at the individual level, to help clinicians and their patients make more informed decisions about adjuvant radiotherapy. Patients with resection of rhabdomyosarcoma between 1990 and 2010 were derived from the Surveillance, Epidemiology and End Results database. A multivariate Cox proportional hazard model was built to model cause-specific survival. We used inverse-probability weighting with propensity scores to minimize selection bias in the observation study. The Akaike information criterion technique was used to reduce variables in the model. Nomograms were created with the reduced model after model selection. The study cohort comprised 1578 patients. The 5-year cause-specific survival rate was 64.3% (95% confidence interval (CI) 61.7?66.9%) and the 10-year cause-specific survival rate was 61.4% (95% CI, 58.7-64.2%) for the entire cohort. Five-year cause-specific survival rates were 62.3% (95% CI, 58.6-66.2%) and 66.1% (95% CI, 62.6-69.8%) for patients with surgery alone and adjuvant radiotherapy, respectively (P<0.01). Age, size, histological type, tumor stage, positive regional nodes and adjuvant radiotherapy were retained in the reduced model. Model performance was good, with a c-index of 0.78 (95% CI, 0.76-0.80). This clinical predictive tool can quantify the benefit of adjuvant radiotherapy after resection of rhabdomyosarcoma, and provide patients and clinicians with assistance in treatment selection.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

No authors listed: Surveillance, Epidemiology, and End Results (SEER) Program (www.seer.cancer.gov) SEER*Stat Database: Incidence - SEER 9 Regs Research Data, Nov 2011 Sub (1973–2010) <Katrina/Rita Population Adjustment> - Linked To County Attributes - Total U.S., 1969–2010 Counties, National Cancer Institute, DCCPS, Surveillance Research Program, Surveillance Systems Branch, released April 2013, based on the November 2012 submission.

2 

Miller RW, Young JL Jr and Novakovic B: Childhood cancer. Cancer. 75:395–405. 1995. View Article : Google Scholar : PubMed/NCBI

3 

Jha P, Frölich AM, McCarville B, et al: Unusual association of alveolar rhabdomyosarcoma with pancreatic metastasis: emerging role of PET-CT in tumor staging. Pediatr Radiol. 40:1380–1386. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Raney RB, Maurer HM, Anderson JR, et al: The Intergroup Rhabdomyosarcoma Study Group (IRSG): major lessons from the IRS-I through IRS-IV studies as background for the current IRS-V treatment protocols. Sarcoma. 5:9–15. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Terezakis SA and Wharam MD: Radiotherapy for rhabdomyosarcoma: indications and outcome. Clin Oncol. 25:27–35. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Wolden SL, Anderson JR, Crist WM, et al: Indications for radiotherapy and chemotherapy after complete resection in rhabdomyosarcoma: A report from the Intergroup Rhabdomyosarcoma Studies I to III. J Clin Oncol. 17:3468–3475. 1999.PubMed/NCBI

7 

Regine WF, Fontanesi J, Kumar P, et al: Local tumor control in rhabdomyosarcoma following low-dose irradiation: comparison of group II and select group III patients. Int J Radiat Oncol Biol Phys. 31:485–491. 1995. View Article : Google Scholar : PubMed/NCBI

8 

Schwartz CL: Long-term survivors of childhood cancer: the late effects of therapy. Oncologist. 4:45–54. 1999.PubMed/NCBI

9 

Stevens MC: Treatment for childhood rhabdomyosarcoma: the cost of cure. Lancet Oncol. 6:77–84. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Schuck A, Mattke AC, Schmidt B, et al: Group II rhabdomyosarcoma and rhabdomyosarcoma-like tumors: is radiotherapy necessary? J Clin Oncol. 22:143–149. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Raney RB, Anderson JR, Barr FG, et al: Rhabdomyosarcoma and undifferentiated sarcoma in the first two decades of life: a selective review of intergroup rhabdomyosarcoma study group experience and rationale for Intergroup Rhabdomyosarcoma Study V. J Pediatr Hematol Oncol. 23:215–220. 2001. View Article : Google Scholar

12 

Koscielniak E, Harms D, Henze G, et al: Results of treatment for soft tissue sarcoma in childhood and adolescence: a final report of the German Cooperative Soft Tissue Sarcoma Study CWS-86. J Clin Oncol. 17:3706–3719. 1999.PubMed/NCBI

13 

Stevens MC, Rey A, Bouvet N, et al: Treatment of nonmetastatic rhabdomyosarcoma in childhood and adolescence: third study of the International Society of Paediatric Oncology - SIOP Malignant Mesenchymal Tumor 89. J Clin Oncol. 23:2618–2628. 2005. View Article : Google Scholar : PubMed/NCBI

14 

No authors listed: Surveillance, Epidemiology, and End Results (SEER) Program (www.seer.cancer.gov) Research Data (1973–2010), National Cancer Institute, DCCPS, Surveillance Research Program, Surveillance Systems Branch, released April 2013, based on the November 2012 submission.

15 

Sultan I, Qaddoumi I, Yaser S, Rodriguez-Galindo C and Ferrari A: Comparing adult and pediatric rhabdomyosarcoma in the surveillance, epidemiology and end results program, 1973 to 2005: an analysis of 2,600 patients. J Clin Oncol. 27:3391–3397. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Harrell FE: rms: Regression Modeling Strategies. R package version 3.6–3. http://CRAN.R-project.org/package=rms.

17 

Austin PC: The relative ability of different propensity score methods to balance measured covariates between treated and untreated subjects in observational studies. Med Decis Making. 29:661–677. 2009. View Article : Google Scholar

18 

Austin PC, Grootendorst P and Anderson GM: A comparison of the ability of different propensity score models to balance measured variables between treated and untreated subjects: a Monte Carlo study. Stat Med. 26:734–753. 2007. View Article : Google Scholar

19 

Harrell FE: Regression Modeling Strategies. Springer-Verlag; New York, New York: 2001, View Article : Google Scholar

20 

R Core Team. 2013, R: A language and environment for statistical computing. R Foundation for Statistical Computing; Vienna, Austria: URL http://www.R-project.org/.

21 

Stephenson AJ, Scardino PT, Kattan MW, et al: Predicting the outcome of salvage radiation therapy for recurrent prostate cancer after radical prostatectomy. J Clin Oncol. 25:2035–2041. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Rouzier R, Pusztai L, Delaloge S, et al: Nomograms to predict pathologic complete response and metastasis-free survival after preoperative chemotherapy for breast cancer. J Clin Oncol. 23:8331–8339. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Brennan MF, Kattan MW, Klimstra D and Conlon K: Prognostic nomogram for patients undergoing resection for adenocarcinoma of the pancreas. Ann Surg. 240:293–298. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Kattan MW, Karpeh MS, Mazumdar M and Brennan MF: Postoperative nomogram for disease-specific survival after an R0 resection for gastric carcinoma. J Clin Oncol. 21:3647–3650. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Yang L, Shen W and Sakamoto N: Population-based study evaluating and predicting the probability of death resulting from thyroid cancer and other causes among patients with thyroid cancer. J Clin Oncol. 31:468–474. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Kutikov A, Egleston BL, Wong YN and Uzzo RG: Evaluating overall survival and competing risks of death in patients with localized renal cell carcinoma using a comprehensive nomogram. J Clin Oncol. 28:311–317. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Kattan MW, Leung DH and Brennan MF: Postoperative nomogram for 12-year sarcoma-specific death. J Clin Oncol. 20:791–796. 2002.PubMed/NCBI

28 

Gronchi A, Miceli R, Shurell E, et al: Outcome prediction in primary resected retroperitoneal soft tissue sarcoma: histology-specific overall survival and disease-free survival nomograms built on major sarcoma center data sets. J Clin Oncol. 31:1649–1655. 2013. View Article : Google Scholar

29 

Chisholm JC, Marandet J, Rey A, et al: Prognostic factors after relapse in nonmetastatic rhabdomyosarcoma: a nomogram to better define patients who can be salvaged with further therapy. J Clin Oncol. 29:1319–1325. 2011. View Article : Google Scholar

30 

Wang SJ, Fuller CD, Kim JS, Sittig DF, Thomas CR Jr and Ravdin PM: Prediction model for estimating the survival benefit of adjuvant radiotherapy for gallbladder cancer. J Clin Oncol. 26:2112–2117. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Wang SJ, Lemieux A, Kalpathy-Cramer J, et al: Nomogram for predicting the benefit of adjuvant chemoradiotherapy for resected gallbladder cancer. J Clin Oncol. 29:4627–4632. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Albert JM, Liu DD, Shen Y, et al: Nomogram to predict the benefit of radiation for older patients with breast cancer treated with conservative surgery. J Clin Oncol. 30:2837–2843. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Flamant F, Rodary C, Rey A, et al: Treatment of non-metastatic rhabdomyosarcomas in childhood and adolescence. Results of the second study of the International Society of Paediatric Oncology: MMT84. Eur J Cancer. 34:1050–1062. 1998. View Article : Google Scholar : PubMed/NCBI

34 

Austin PC: The performance of different propensity score methods for estimating marginal hazard ratios. Stat Med. 32:2837–2849. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Shen W, Sakamoto N and Yang L: Model to predict the survival benefit of radiation for patients with rhabdomyosarcoma after surgery: A population-based study. Int J Oncol 45: 549-557, 2014.
APA
Shen, W., Sakamoto, N., & Yang, L. (2014). Model to predict the survival benefit of radiation for patients with rhabdomyosarcoma after surgery: A population-based study. International Journal of Oncology, 45, 549-557. https://doi.org/10.3892/ijo.2014.2466
MLA
Shen, W., Sakamoto, N., Yang, L."Model to predict the survival benefit of radiation for patients with rhabdomyosarcoma after surgery: A population-based study". International Journal of Oncology 45.2 (2014): 549-557.
Chicago
Shen, W., Sakamoto, N., Yang, L."Model to predict the survival benefit of radiation for patients with rhabdomyosarcoma after surgery: A population-based study". International Journal of Oncology 45, no. 2 (2014): 549-557. https://doi.org/10.3892/ijo.2014.2466
Copy and paste a formatted citation
x
Spandidos Publications style
Shen W, Sakamoto N and Yang L: Model to predict the survival benefit of radiation for patients with rhabdomyosarcoma after surgery: A population-based study. Int J Oncol 45: 549-557, 2014.
APA
Shen, W., Sakamoto, N., & Yang, L. (2014). Model to predict the survival benefit of radiation for patients with rhabdomyosarcoma after surgery: A population-based study. International Journal of Oncology, 45, 549-557. https://doi.org/10.3892/ijo.2014.2466
MLA
Shen, W., Sakamoto, N., Yang, L."Model to predict the survival benefit of radiation for patients with rhabdomyosarcoma after surgery: A population-based study". International Journal of Oncology 45.2 (2014): 549-557.
Chicago
Shen, W., Sakamoto, N., Yang, L."Model to predict the survival benefit of radiation for patients with rhabdomyosarcoma after surgery: A population-based study". International Journal of Oncology 45, no. 2 (2014): 549-557. https://doi.org/10.3892/ijo.2014.2466
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team