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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September-2014 Volume 45 Issue 3

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Review

MicroRNAs in the diagnosis and prognosis of breast cancer and their therapeutic potential (Review)

  • Authors:
    • Kaiyuan Zhang
    • Yanlei Zhang
    • Chang Liu
    • Ying Xiong
    • Jiqiang Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Neurobiology, Chongqing Key Laboratory of Neurobiology, Third Military Medical University, Chongqing 400038, P.R. China, Cadet Brigade, Third Military Medical University, Chongqing 400038, P.R. China
  • Pages: 950-958
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    Published online on: June 10, 2014
       https://doi.org/10.3892/ijo.2014.2487
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Abstract

MicroRNAs (miRNAs) are non-coding single-stranded RNAs in eukaryotes and are involved in the regulation of the post-transcriptional expression of specific genes. Studies have demonstrated that miRNAs play important roles in regul­ating diverse physiological events such as cell proliferation, differentiation and embryo development. In recent decades, considerable attention has been given to the relationship between miRNA and the pathology of cancers, particularly breast cancer. A large number of miRNAs have been shown to be involved in the pathophysiology of breast cancer. Studies have revealed that some miRNAs might regulate the oncogenesis and growth of breast cancer by acting on breast tumor-initiating cells or other downstream targets. Studies have also demonstrated that some miRNAs act as suppressors of metastasis or promoters of breast cancer. Additionally, certain miRNAs are involved in cancer tissue angiogenesis (one of the most important mechanisms of tumor growth and metastasis). Clinical evidence indicates that some miRNAs can be used as diagnostic and prognostic biomarkers for breast cancer due to their significantly increased or decreased expression in cancer tissue. Moreover, certain miRNAs may have therapeutic potential for targeting ER-α/HER, breast tumor-initiating cells and metastasis as well as multidrug resistance. In this review, we discuss the relationship between miRNAs and the pathogenesis of breast cancer as well as the progress of current research on the miRNA-specific diagnosis, prognosis and treatment of breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang K, Zhang Y, Liu C, Xiong Y and Zhang J: MicroRNAs in the diagnosis and prognosis of breast cancer and their therapeutic potential (Review). Int J Oncol 45: 950-958, 2014.
APA
Zhang, K., Zhang, Y., Liu, C., Xiong, Y., & Zhang, J. (2014). MicroRNAs in the diagnosis and prognosis of breast cancer and their therapeutic potential (Review). International Journal of Oncology, 45, 950-958. https://doi.org/10.3892/ijo.2014.2487
MLA
Zhang, K., Zhang, Y., Liu, C., Xiong, Y., Zhang, J."MicroRNAs in the diagnosis and prognosis of breast cancer and their therapeutic potential (Review)". International Journal of Oncology 45.3 (2014): 950-958.
Chicago
Zhang, K., Zhang, Y., Liu, C., Xiong, Y., Zhang, J."MicroRNAs in the diagnosis and prognosis of breast cancer and their therapeutic potential (Review)". International Journal of Oncology 45, no. 3 (2014): 950-958. https://doi.org/10.3892/ijo.2014.2487
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang K, Zhang Y, Liu C, Xiong Y and Zhang J: MicroRNAs in the diagnosis and prognosis of breast cancer and their therapeutic potential (Review). Int J Oncol 45: 950-958, 2014.
APA
Zhang, K., Zhang, Y., Liu, C., Xiong, Y., & Zhang, J. (2014). MicroRNAs in the diagnosis and prognosis of breast cancer and their therapeutic potential (Review). International Journal of Oncology, 45, 950-958. https://doi.org/10.3892/ijo.2014.2487
MLA
Zhang, K., Zhang, Y., Liu, C., Xiong, Y., Zhang, J."MicroRNAs in the diagnosis and prognosis of breast cancer and their therapeutic potential (Review)". International Journal of Oncology 45.3 (2014): 950-958.
Chicago
Zhang, K., Zhang, Y., Liu, C., Xiong, Y., Zhang, J."MicroRNAs in the diagnosis and prognosis of breast cancer and their therapeutic potential (Review)". International Journal of Oncology 45, no. 3 (2014): 950-958. https://doi.org/10.3892/ijo.2014.2487
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